DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and TLR8

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_057694.2	Gene:	TLR8 / 51311	HGNCID:	15632	Length:	1059	Species:	Homo sapiens

Alignment Length:	417	Identity:	92/417 - (22%)
Similarity:	149/417 - (35%)	Gaps:	122/417 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNLSL 106
            |.::..| .||....:||:.                      .:.::..:....|||....|||.
Human   491 PLIKPQC-AAYGKALDLSLN----------------------SIFFIGPNQFENLPDIACLNLSA 532

  Fly   107 H-NLQLSSCGIQRIATGAFKGQE----SVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLS 166
            : |.|:.|            |.|    ..::.|:|.:|.|......||..|..|.:||||.|  |
Human   533 NSNAQVLS------------GTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN--S 583

  Fly   167 HIPDDAFV--------GLTKLSTLKLNDNNVTLASNAFRGLEQSLKNLNLKGTK--------QRK 215
            |....|.|        ..|.|..|.|:.||:...::.:....:||..|...|.:        ..:
Human   584 HYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNR 648

  Fly   216 VPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDA-LTALNLERNLIQSIGET--------- 270
            .....:|||:|..||||.|.:|.:|.    ..|..|.| ||.|::..|:::....|
Human   649 YISIFKGLKNLTRLDLSLNRLKHIPN----EAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLE 709

  Fly   271 --------------AFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAF 321
                          :.:....:|.:|.|.:|.::..|.|.:..:..|:.||:..|||.::.::|.
Human   710 LLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSAL 774

  Fly   322 --RGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKL----RWVAEWIRNGDL 380
              :....:::|.|.|||                         ..|.|.:    ||:.|     .|
Human   775 ETKTTTKLSMLELHGNP-------------------------FECTCDIGDFRRWMDE-----HL 809

  Fly   381 QVTSRERNPQFCGTPPRFRDRGFYSIQ 407
            .|.........|.:|...|.:...|::
Human   810 NVKIPRLVDVICASPGDQRGKSIVSLE 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	53/220 (24%)
		leucine-rich repeat	86..105	CDD:275380	4/18 (22%)
		leucine-rich repeat	106..129	CDD:275380	5/27 (19%)
		LRR_8	131..189	CDD:338972	22/65 (34%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/30 (33%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		leucine-rich repeat	203..225	CDD:275380	5/29 (17%)
		leucine-rich repeat	226..253	CDD:275380	10/26 (38%)
		LRR_8	254..337	CDD:338972	22/107 (21%)
		leucine-rich repeat	254..302	CDD:275380	11/70 (16%)
		leucine-rich repeat	303..326	CDD:275380	7/24 (29%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		PCC	332..>413	CDD:188093	15/80 (19%)
		PRK10927	<1061..>1097	CDD:236797
TLR8	NP_057694.2	LRR_8	83..155	CDD:290566
		leucine-rich repeat	83..106	CDD:275380
		leucine-rich repeat	107..144	CDD:275380
		leucine-rich repeat	145..165	CDD:275380
		leucine-rich repeat	166..189	CDD:275380
		leucine-rich repeat	190..220	CDD:275380
		leucine-rich repeat	221..241	CDD:275380
		LRR_8	240..317	CDD:290566
		leucine-rich repeat	242..265	CDD:275380
		leucine-rich repeat	266..306	CDD:275380
		LRR_8	305..367	CDD:290566
		leucine-rich repeat	307..330	CDD:275380
		leucine-rich repeat	331..356	CDD:275380
		leucine-rich repeat	387..413	CDD:275380
		LRR_8	412..>449	CDD:290566
		leucine-rich repeat	414..437	CDD:275380
		LRR_8	502..560	CDD:290566	16/91 (18%)
		LRR_RI	<504..719	CDD:238064	59/254 (23%)
		leucine-rich repeat	504..524	CDD:275380	3/41 (7%)
		leucine-rich repeat	525..549	CDD:275380	8/35 (23%)
		LRR_8	548..614	CDD:290566	22/67 (33%)
		leucine-rich repeat	550..573	CDD:275380	7/22 (32%)
		leucine-rich repeat	574..603	CDD:275380	10/30 (33%)
		leucine-rich repeat	604..658	CDD:275380	11/53 (21%)
		LRR_8	657..718	CDD:290566	17/64 (27%)
		leucine-rich repeat	659..683	CDD:275380	10/27 (37%)
		leucine-rich repeat	684..707	CDD:275380	5/22 (23%)
		LRR_8	706..766	CDD:290566	10/59 (17%)
		leucine-rich repeat	708..730	CDD:275380	0/21 (0%)
		leucine-rich repeat	732..755	CDD:275380	6/22 (27%)
		leucine-rich repeat	756..775	CDD:275380	7/18 (39%)
		LRRCT	790..835	CDD:214507	12/74 (16%)
		TIR	898..1040	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910