DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and Tollo

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	122/528 - (23%)
Similarity:	184/528 - (34%)	Gaps:	174/528 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 RELSVQCDQVDFS--QLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNL-SLHNLQLSSCGIQ 117
            |.|:::....|:|  .|..|.|:....:.::.|.::.:.|..:||.:...| ||.:|..|...||
  Fly   125 RNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQ 189

  Fly   118 RIATGAFKGQ---------ESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAF 173
            .|:...|...         .|.|::|:|..|.:..:|...|..||:|..|:::||.:|.:.|.||
  Fly   190 DISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAF 254

  Fly   174 VGLTKLSTLKLNDNNVT-----------------------------------------LASN--- 194
            .||..|..:.|:.|.:|                                         ||||
  Fly   255 EGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELN 319

  Fly   195 -------AFRGLEQSLKNLNLKGTKQRKVPESI-RGLKSLAFLDLSQNGIKELPGAGGI------ 245
                   .|.||:: |..|:|...|..::...| |.|.||..|.|..|.|.:||  |||
  Fly   320 SQWINAATFVGLKR-LMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLP--GGIFADLTN 381

  Fly   246 ----------------RVFDGLDALTALNLERNLIQ----------------------------- 265
                            |...||..|..|:|:.|.|.
  Fly   382 LHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEA 446

  Fly   266 ----------SIGETAFAGVRKT-------LSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLL 313
                      .:||...:.:..|       |..|.:..|.|.....|....:..|::|::..|.|
  Fly   447 LAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKL 511

  Fly   314 TSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGR------FLHCDCKLRWVA 372
            .|:...:.:.|..:..:.||||.|.|: .|.|..| ..|..|::.|.      :.|....|:|:
  Fly   512 KSIEAGSLQRNSQLQAIRLDGNQLKSI-AGLFTEL-PNLVWLNISGNRLEKFDYSHIPIGLQWL- 573

  Fly   373 EWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNL--KPTL 435
                  |::..             |....|.|.....|||.... ||:.        ||  :.|.
  Fly   574 ------DVRAN-------------RITQLGNYFEIESELSLSTF-DASY--------NLLTEITA 610

  Fly   436 PSSPDSVE 443
            .|.|:|||
  Fly   611 SSIPNSVE 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	70/281 (25%)
		leucine-rich repeat	86..105	CDD:275380	5/19 (26%)
		leucine-rich repeat	106..129	CDD:275380	7/31 (23%)
		LRR_8	131..189	CDD:338972	21/57 (37%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	11/73 (15%)
		leucine-rich repeat	203..225	CDD:275380	7/22 (32%)
		leucine-rich repeat	226..253	CDD:275380	13/48 (27%)
		LRR_8	254..337	CDD:338972	23/128 (18%)
		leucine-rich repeat	254..302	CDD:275380	13/93 (14%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		PCC	332..>413	CDD:188093	21/86 (24%)
		PRK10927	<1061..>1097	CDD:236797
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	43/155 (28%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380	5/18 (28%)
		LRR_8	152..222	CDD:290566	18/69 (26%)
		leucine-rich repeat	154..177	CDD:275380	5/22 (23%)
		leucine-rich repeat	178..201	CDD:275380	7/22 (32%)
		LRR	210..656	CDD:227223	102/443 (23%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..259	CDD:275380	10/22 (45%)
		leucine-rich repeat	260..283	CDD:275380	4/22 (18%)
		LRR_RI	276..558	CDD:238064	59/286 (21%)
		leucine-rich repeat	284..307	CDD:275380	0/22 (0%)
		leucine-rich repeat	308..333	CDD:275380	7/24 (29%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	10/24 (42%)
		leucine-rich repeat	382..405	CDD:275380	3/22 (14%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	0/21 (0%)
		leucine-rich repeat	453..500	CDD:275380	8/46 (17%)
		leucine-rich repeat	501..521	CDD:275380	5/19 (26%)
		leucine-rich repeat	525..547	CDD:275380	9/23 (39%)
		leucine-rich repeat	548..573	CDD:275380	5/24 (21%)
		leucine-rich repeat	604..640	CDD:275380	7/15 (47%)
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910