DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and kek6

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	1216	Identity:	235/1216 - (19%)
Similarity:	359/1216 - (29%)	Gaps:	491/1216 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 SKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASN---AFRGLEQSLKNLNLKGTKQRKV-PESIR 221
            |..||:.||:..   .|:|..|.||||::...:.   :..|| .:|:.:.||.::.:.: .||.|
  Fly    56 SSLQLTTIPNTL---STELQVLVLNDNHIPYLNREEFSTLGL-LNLQRIYLKKSEVQYIHKESFR 116

  Fly   222 GLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLN 286
            .||.|..:|||.|.::.|..    ..|.|.|.|..|.|..|.:            |.|::.
  Fly   117 NLKILVEIDLSDNKLEMLDK----DTFMGNDRLRILYLNGNPL------------KRLAAY---- 161

  Fly   287 NLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNAT 351
                :|||     |..||.||:...|::.:...:......:..|.|..|.|.|:.|..|.|: |.
  Fly   162 ----QFPI-----LPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHM-AN 216

  Fly   352 LRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDI 416
            |:.|||......|:||||....|..|..|...|     ..|..||..:||.:.|:..|...|
  Fly   217 LKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVS-----LVCKGPPAQKDRTWDSVDDELFGC--- 273

  Fly   417 ADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTT 481
                                  |..||.........:..|
  Fly   274 ----------------------PPRVEIFNNEEVQNIDIG------------------------- 291

  Fly   482 TTTAEPTTRRSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITTSSSSSSSSSTSTGHGN 546
                              |.||.|.
  Fly   292 ------------------SNTTFSC---------------------------------------- 298

  Fly   547 GKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYP-PQ-----RGTRIDDANEVQVKHAFR 605
                                             ||.|.| |:     .|..:|:.|.:     |.
  Fly   299 ---------------------------------LVYGDPLPEVAWELNGKILDNDNVL-----FE 325

  Fly   606 QDSSVIIQWDSDTANILGFRV------VYRLFGEKAFKQGPPLESSEREFKIKNVPAQECIIVCV 664
            .:|   |..|...:|:..|.|      .|...|..:               |.::.....|.:..
  Fly   326 SES---IASDKLWSNLTVFNVTSLDAGTYACTGSNS---------------IGSMTQNISIYLSE 372

  Fly   665 ISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASAAICGTI--IVAVIVFIAASRRSRKL 727
            |....|..||||..|                    ......|.||:  ::::...:...:|:.:.
  Fly   373 IVQHVLEKTPETFWY--------------------FGLIMGIFGTVFLLISISFVVCLCKRTTRQ 417

  Fly   728 QSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHKEWDQVSAYSGRSIPRPRIYPVE-Q 791
            .....|:                  |...|:    :||:.::....|:.:..:..|...|.:: |
  Fly   418 HRHANKA------------------GVKSSV----SFNDQEKKLLDSSVTTTTNDRGDSYGIDNQ 460

  Fly   792 PDDMRSHFSGMPGKVGKSRSLADGQSQ-HSFSNNSHRGYLGSAFPSNLVNSRPELRQSRQSLAAA 855
            |..:     ||  ..|.|..:...|.: |:..::.|        .|.||..:|:.:|.
  Fly   461 PTSI-----GM--NKGDSAGMGFNQIEIHAVESHRH--------GSMLVQQQPQQQQV------- 503

  Fly   856 SERMSRASYAGSIHGGNGGGGGLGGNGGGGGNGLPVSSLMAMSGMVGG--GGPASIASSARRSRP 918
                             .||||:.            ..||.:.....|  ..|.|:|.
  Fly   504 -----------------AGGGGMR------------QQLMQVKDSTCGMMSVPTSMAG------- 532

  Fly   919 RSRSREQLNTTHIHNHRPGSRYSQAGSTHTLN--------NYCD------------------TSD 957
                       |.|:|.     :|......||        .:|.                  |.|
  Fly   533 -----------HAHSHP-----AQISEEFPLNVGVFPPPPEFCSNIVPNPAFGGNIFIRVSVTQD 581

  Fly   958 NWTDHDMDIYMARNPTTRNGLVPLXGRLTLSXYFNVVLNWDGIFXQYLTPTIEGTEGRGRGRRQQ 1022
            .....|:::|    |...|  :|...:.........|...:|.|         .|..|...||..
  Fly   582 MLDGADLNMY----PDLLN--IPKRMQDVQESGAGAVAVPEGQF---------ATLPRHTARRGI 631

  Fly  1023 QQQQQQQQQQQQQHQQLQHQQQQQHQHQLQQLRNERHQQRHRNDQQWEQPYQPAQQQHQRLQYYM 1087
            .::....||||||||| |||.|||.|.  ||::.::|||              .|||||
  Fly   632 LKKDTSLQQQQQQHQQ-QHQHQQQQQQ--QQIQQQQHQQ--------------LQQQHQ------ 673

  Fly  1088 PQTERCTSPPDVVPRAANFHNS----NTTSTGHNDNSNSHGSSSSSSSNIAQQQQAPLAAMTAAL 1148
                         |.....|:.    |..::|::.:.:.:.|::     :......|..|:||
  Fly   674 -------------PSGLYTHDEIVTYNLEASGYDPHQSGYHSNA-----MELPPPPPPPAVTA-- 718

  Fly  1149 GDATAAATAAAAAAASASGIVVENYFNEYERQEIIYHHPTSRRSSSSSSSCSAAATRHVPRSNAF 1213
                                ||:            .|||       |.::|::......|..:|
  Fly   719 --------------------VVQ------------CHHP-------SPNNCASCINNAPPPPSA- 743

  Fly  1214 RLQLPAVATATTNNILYNISNKHGATGH----NGSIGNYKAHTFSDSCNCTCNCSLSEEEEISQE 1274
             .|.|.|.......:..:...|:...|.    :|.:|.             .|.||.:||....|
  Fly   744 -CQSPPVEVTPMRPLDSSAYPKYDNMGRRITASGGLGG-------------SNLSLHDEERYENE 794

  Fly  1275 TAAVTAAAGEDGDQAGSSLSSTSVSSIEQVQQGQQEQQGQEVYLSL 1320
            |....|    :....|....|..:...::|.|||.:..|...::||
  Fly   795 TLFGQA----ESQTKGMPEQSQDLHQPQEVTQGQDKGGGPGEFVSL 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	30/94 (32%)
		leucine-rich repeat	86..105	CDD:275380
		leucine-rich repeat	106..129	CDD:275380
		LRR_8	131..189	CDD:338972	12/27 (44%)
		leucine-rich repeat	131..154	CDD:275380
		leucine-rich repeat	155..178	CDD:275380	5/16 (31%)
		leucine-rich repeat	179..202	CDD:275380	8/25 (32%)
		leucine-rich repeat	203..225	CDD:275380	7/22 (32%)
		leucine-rich repeat	226..253	CDD:275380	8/26 (31%)
		LRR_8	254..337	CDD:338972	18/82 (22%)
		leucine-rich repeat	254..302	CDD:275380	10/47 (21%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		PCC	332..>413	CDD:188093	28/80 (35%)
		PRK10927	<1061..>1097	CDD:236797	6/35 (17%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/25 (32%)
		LRR_8	96..155	CDD:290566	21/62 (34%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	8/26 (31%)
		LRR_4	144..186	CDD:289563	15/66 (23%)
		leucine-rich repeat	145..168	CDD:275380	10/47 (21%)
		leucine-rich repeat	169..216	CDD:275380	13/47 (28%)
		LRRCT	225..274	CDD:214507	17/78 (22%)
		Ig	295..367	CDD:143165	20/167 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100