DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and Toll-6

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	1476	Identity:	281/1476 - (19%)
Similarity:	482/1476 - (32%)	Gaps:	443/1476 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TSCICAYNLGRELSVQCDQVDFSQ---LLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNL-SL 106
            |||          |:..:.:|.|.   ::...|....|:.:.:|.|||:.||.:.|...|.| :|
  Fly   273 TSC----------SLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNL 327

  Fly   107 HNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSH--IP 169
            ..|.|||..|..:.|..|..|..:::.:.||:|.::.:..:....|.:|..||||.||::.  |.
  Fly   328 QILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWID 392

  Fly   170 DDAFVGLTKLSTLKLNDNNVT-LASNAFRGLEQSLKNLNLKGTKQRKV-PESIRGLKSLAFLDLS 232
            .:.||||.:|..|.|:.|.:| |....|..| .:|:.|||:..:...: .::...:.:|..|.||
  Fly   393 KNTFVGLIRLVLLNLSHNKLTKLEPEIFSDL-YTLQILNLRHNQLENIAADTFAPMNNLHTLLLS 456

  Fly   233 QNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAV 297
            .|.:|.|..    ...:||..|:.|:|:.|.:..:...||... ..|..|:|..|.|...|: |:
  Fly   457 HNKLKYLDA----YALNGLYVLSLLSLDNNALIGVHPDAFRNC-SALQDLNLNGNQLKTVPL-AL 515

  Fly   298 HSLKELRVLDIGFNLLTSLPEAAFRG------------------------NPGITLLALDGNPLS 338
            .:::.||.:|:|.|::|.:.::||:|                        .|.:.:|.|..|.::
  Fly   516 RNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIA 580

  Fly   339 SVPEGAFAHLNATLRGLSLGGR--------FLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTP 395
            .|..||| .:.::::.:.|.|.        |.:....|     |:...|.::.|.:
  Fly   581 VVEPGAF-EMTSSIQAVRLDGNELNDINGLFSNMPSLL-----WLNISDNRLESFD--------- 630

  Fly   396 PRFRDRGFYSIQPEELSCPDIAD---AALRGPVGLADNLK-PTLPSSPDSVEYETGTGTGTVGTG 456
                    |...|..|...|:..   ::|....||...|| .||..|.:.::        .:|
  Fly   631 --------YGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQ--------RIG-- 677

  Fly   457 TAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTASPASNPPVNGTG 521
                   .||:.:|..... ......||.:|.|....|     :.|.:.
  Fly   678 -------PSSIPNSIELLF-LNDNLITTVDPDTFMHKT-----NLTRVD---------------- 713

  Fly   522 TVQATSITTSSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPP 586
             :.|..|||....|.           :..|.|.                  |:......:.|.|.
  Fly   714 -LYANQITTLDIKSL-----------RILPVWE------------------HRALPEFYIGGNPF 748

  Fly   587 QRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFKI 651
            .....||...  ::.|...:....|:..::....:|..|       |:|:.  |.:|:..:.|..
  Fly   749 TCDCNIDWLQ--KINHITSRQYPRIMDLETIYCKLLNNR-------ERAYI--PLIEAEPKHFLC 802

  Fly   652 KNVPAQECIIVCVISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASAAICGTIIVAVIV 716
              .....|..||           ....:..|....|..:..:.....|.:.:...|..
  Fly   803 --TYKTHCFAVC-----------HCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSG------- 847

  Fly   717 FIAASRRSRKLQSSQQKSPLPIGGLPVNCCGPTGSPGPLG--SIATLSAFNNHKEWDQVSAYSGR 779
             .|.|...|::  ....|.|.|.|   |..........||  ::|.|.|.|::......:.:||
  Fly   848 -AAYSEMPRRV--PMDTSELYIDG---NNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSG- 905

  Fly   780 SIPRPRIYPVEQPDDMRSHFSGMPG--------------KVGKSRSLADGQSQ------------ 818
             :.|..|..:|.     :|...:.|              :..|..|:|:|..|
  Fly   906 -LKRLLILHLED-----NHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDG 964

  Fly   819 ----H---------------SFSNNS----------HRGYLGSAFPSNLVNSRPE---------L 845
                |               |.::|.          .|.|||.:....:..||..         |
  Fly   965 NRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVL 1029

  Fly   846 RQSRQSLAAASERMSRASYAGSIHGGNGGGGGLGGNGGGGGNGLPV-----SSLMAMSGMVGGGG 905
            |:...:.....:.::...:...|.|                 .||:     .:.:|..|::.|
  Fly  1030 REKNGTKCTLRDGVAHYMHTNEIEG-----------------LLPLLLVATCAFVAFFGLIFG-- 1075

  Fly   906 PASIASSARRSRPRSRSREQLNTTHIHNHRPGSRYSQAGSTHTLNNYCDTSDNWTD-----HDMD 965
                                   ...:.|   .....|.||:.|.|:|..|..:.|     ...|
  Fly  1076 -----------------------LFCYRH---ELKIWAHSTNCLMNFCYKSPRFVDQLDKERPND 1114

  Fly   966 IYMARN------------PTTRNGLVPLXGRLTLSXYFNVVLNWDGIFXQYLTPT-IEGTEGRGR 1017
            .|.|.:            .|..|   .: .||.|  |.:|.:|      .|:|.. ||..|...:
  Fly  1115 AYFAYSLQDEHFVNQILAQTLEN---DIGYRLCL-HYRDVNIN------AYITDALIEAAESAKQ 1169

  Fly  1018 GRRQQQQQQQQQQQQQQQHQQLQHQQQQQHQHQLQQLRNE----------RHQQRHRNDQQWEQP 1072
            ......:.....:..:.:::...|:..::.:..:..|..:          ||..|.....:|:.
  Fly  1170 FVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCIEWDD- 1233

  Fly  1073 YQPAQQQHQRLQYYMPQTERCTSPPDVVPRAANFHNSNTTS---TGHNDNSNSHGSSSSSSSNIA 1134
                ::..|:|:..:|           :|.....:|....|   :|...:.|.:.:|....:...
  Fly  1234 ----KKFWQKLRLALP-----------LPNGRGNNNKRVVSGCLSGRTPSVNMYATSHEYQAGNG 1283

  Fly  1135 QQQQAPLAAMT-------AALGDATAAA---------TAAAAAAASASGIVVENYFNEYERQEII 1183
            .....|.|...       |.:.:..||.         |:|:||||:.....:.....:.:|...:
  Fly  1284 GVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASAAAAACKFNTMNQLSKKQQRDLSV 1348

  Fly  1184 ------------YHHPTSRRSSSSSSSCSAAATRHVPRSNAFRLQLPAVATA------------- 1223
                        ::|..:|||....:         ||.      .||:.|.|
  Fly  1349 AGMAKTLEHQHHHNHQANRRSQHEYA---------VPS------YLPSAAPAYDSVDYAKQQIRN 1398

  Fly  1224 TTNNILYNISNKHGATGHNGSIGNYKAHTFSD--------SCNCTCNCSLSEEEEISQETAAVTA 1280
            ..|....|:.....|.|.|.:.|  ...:||.        |.||..:||...::|:       ..
  Fly  1399 NANCECVNLGTAKRAAGKNPASG--LPSSFSSNFVPPGGASYNCKKSCSCIGDDEL-------LC 1454

  Fly  1281 AAGEDGDQAGSSLSSTSVSSIEQVQQGQQEQQGQEVYLSLNLTLAD 1326
            :.|..|....:.|.|.:.||:.........:|.:..:...||:|.|
  Fly  1455 SCGGGGGIGVNLLESGTQSSVTMSSSSNNSRQPELTHYESNLSLND 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	59/207 (29%)
		leucine-rich repeat	86..105	CDD:275380	9/19 (47%)
		leucine-rich repeat	106..129	CDD:275380	9/22 (41%)
		LRR_8	131..189	CDD:338972	20/59 (34%)
		leucine-rich repeat	131..154	CDD:275380	4/22 (18%)
		leucine-rich repeat	155..178	CDD:275380	12/24 (50%)
		leucine-rich repeat	179..202	CDD:275380	8/23 (35%)
		leucine-rich repeat	203..225	CDD:275380	4/22 (18%)
		leucine-rich repeat	226..253	CDD:275380	9/26 (35%)
		LRR_8	254..337	CDD:338972	26/106 (25%)
		leucine-rich repeat	254..302	CDD:275380	13/47 (28%)
		leucine-rich repeat	303..326	CDD:275380	9/46 (20%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	16/88 (18%)
		PRK10927	<1061..>1097	CDD:236797	5/35 (14%)
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	4/14 (29%)
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	57/194 (29%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	301..386	CDD:290566	28/84 (33%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR	350..729	CDD:227223	101/459 (22%)
		leucine-rich repeat	352..375	CDD:275380	4/22 (18%)
		leucine-rich repeat	376..401	CDD:275380	12/24 (50%)
		LRR_RI	<401..626	CDD:238064	57/237 (24%)
		leucine-rich repeat	402..425	CDD:275380	8/23 (35%)
		leucine-rich repeat	426..449	CDD:275380	4/22 (18%)
		leucine-rich repeat	450..473	CDD:275380	9/26 (35%)
		leucine-rich repeat	474..497	CDD:275380	6/23 (26%)
		leucine-rich repeat	498..518	CDD:275380	7/20 (35%)
		leucine-rich repeat	521..544	CDD:275380	9/22 (41%)
		leucine-rich repeat	545..566	CDD:275380	0/20 (0%)
		leucine-rich repeat	569..592	CDD:275380	7/23 (30%)
		leucine-rich repeat	593..615	CDD:275380	3/21 (14%)
		leucine-rich repeat	616..637	CDD:275380	6/42 (14%)
		leucine-rich repeat	638..662	CDD:275380	5/23 (22%)
		leucine-rich repeat	663..684	CDD:275380	6/37 (16%)
		leucine-rich repeat	685..708	CDD:275380	5/28 (18%)
		leucine-rich repeat	709..728	CDD:275380	6/46 (13%)
		LRR_8	883..943	CDD:290566	11/66 (17%)
		leucine-rich repeat	885..908	CDD:275380	6/24 (25%)
		leucine-rich repeat	909..932	CDD:275380	4/27 (15%)
		LRR_8	932..990	CDD:290566	7/57 (12%)
		leucine-rich repeat	933..956	CDD:275380	5/22 (23%)
		TIR	1114..1247	CDD:214587	25/158 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910