DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and flrt2

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_002933238.1	Gene:	flrt2 / 395015	XenbaseID:	XB-GENE-495394	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	665	Identity:	146/665 - (21%)
Similarity:	241/665 - (36%)	Gaps:	211/665 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LKPVDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADV 144
            ::.||.:|:..:.:.|.|..:..|:.:.:||.::  ||.|:..|. .|.:.|..|:|.||.::.|
Frog   112 VQSVDTVYLYGNQLDEFPMNLPKNVRVLHLQENN--IQTISRVAL-AQLTKLEELHLDDNSISTV 173

  Fly   145 PVE--ALKVLGKLNLLDLSKNQLSHIPDDAFVGLTK-LSTLKLNDNNV-TLASNAFRGLEQSLKN 205
            .||  |.:....|.:|.||||.||.:|    |||.. |..|:|::|.: |::..||:.| .:|:.
Frog   174 GVEDGAFREAISLKMLFLSKNHLSSVP----VGLPLCLQELRLDENRIATISDQAFQNL-TNLER 233

  Fly   206 LNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGET 270
            |.|.|..                  |:..||.:       ..|..|..|...::.||.: :...|
Frog   234 LILDGNL------------------LTNKGITD-------GTFSHLPKLKEFSMVRNSL-TTPPT 272

  Fly   271 AFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGN 335
            ...|.  .|..|:|.:|.:...|:.|..||.:|..|||..|.|..|.:..|.....:..|....|
Frog   273 DLQGT--YLVKLNLQDNQINHIPVSAFASLHKLERLDISNNRLKMLTKGVFDNLTNLKQLTARNN 335

  Fly   336 PLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRD 400
            |                         .:|||.:|||.||:::....:..|   ...|..|..||.
Frog   336 P-------------------------WYCDCSIRWVTEWLKSLPAAINVR---AFMCQGPEHFRG 372

  Fly   401 RGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTS 465
            .....:....||||               ...|.||                         ||||
Frog   373 MAVRELNVNLLSCP---------------TTTPILP-------------------------PVTS 397

  Fly   466 SVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITT 530
            : |.:.:.|||.:|....|        .|..||:.|.|        .|.||::.|...|...:
Frog   398 A-SPTIAPTTPLSTVFIVT--------PTEAPTEPTPT--------PSLPPISPTLPDQVIIV-- 443

  Fly   531 SSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPPQRGTRIDDA 595
                            .|..|                    ||:
Frog   444 ----------------DKVTP--------------------LHQ--------------------- 451

  Fly   596 NEVQVKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQG---PPLESSER-EFKIKNVPA 656
            :.:|:...:..::.|.::|.| ..:::.|::.:...|. :..:|   ..:.||:| .|.:.|:..
Frog   452 DRLQIVIHYVNNTCVNVKWIS-FISVISFKLTWVKMGH-SLVEGIVHERIVSSDRLHFTLVNLEP 514

  Fly   657 QECIIVCVISLEELH---VTPETVPYQQCREVRTVAS-------QASNMDKIT-------IAASA 704
            :....:|::.|:..:   ...|||    |.|..|.||       ..|:.::.|       ...:.
Frog   515 KSTYRICLVPLDAFNNYQAGEETV----CAEAITKASLLNNGSNSPSSHEQTTPQGMGSPFLLAG 575

  Fly   705 AICGTIIVAVIVFIA 719
            .|.|.:|:.:::.::
Frog   576 LIGGAVIIVLVLLLS 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	50/175 (29%)
		leucine-rich repeat	86..105	CDD:275380	4/18 (22%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		LRR_8	131..189	CDD:338972	25/60 (42%)
		leucine-rich repeat	131..154	CDD:275380	9/24 (38%)
		leucine-rich repeat	155..178	CDD:275380	12/22 (55%)
		leucine-rich repeat	179..202	CDD:275380	8/23 (35%)
		leucine-rich repeat	203..225	CDD:275380	4/21 (19%)
		leucine-rich repeat	226..253	CDD:275380	5/26 (19%)
		LRR_8	254..337	CDD:338972	23/82 (28%)
		leucine-rich repeat	254..302	CDD:275380	13/47 (28%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	3/22 (14%)
		PCC	332..>413	CDD:188093	16/80 (20%)
		PRK10927	<1061..>1097	CDD:236797
flrt2	XP_002933238.1	LRRNT	60..91	CDD:214470
		leucine-rich repeat	90..111	CDD:275378
		leucine-rich repeat	117..135	CDD:275380	3/17 (18%)
		PPP1R42	118..336	CDD:411060	71/253 (28%)
		leucine-rich repeat	136..159	CDD:275380	7/25 (28%)
		leucine-rich repeat	160..185	CDD:275380	9/24 (38%)
		leucine-rich repeat	186..206	CDD:275380	12/23 (52%)
		leucine-rich repeat	207..230	CDD:275380	8/23 (35%)
		leucine-rich repeat	231..256	CDD:275380	9/49 (18%)
		leucine-rich repeat	257..278	CDD:275380	5/23 (22%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		PCC	307..>384	CDD:188093	22/104 (21%)
		tatB	<386..437	CDD:166942	23/107 (21%)
		FN3	455..537	CDD:419708	14/83 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910