DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment haf and caps

DIOPT Version :9

Sequence 1:NP_001356954.1 Gene:haf / 33339 FlyBaseID:FBgn0261509 Length:1347 Species:Drosophila melanogaster
Sequence 2:NP_001303391.1 Gene:caps / 39493 FlyBaseID:FBgn0023095 Length:811 Species:Drosophila melanogaster


Alignment Length:698 Identity:177/698 - (25%)
Similarity:255/698 - (36%) Gaps:168/698 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LLLLLPLILGRLHVA--HAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMN---- 75
            |.|.|.|:|..|.||  .|.||         ..|.|..:   .|.|.|.:.....|..|:|    
  Fly    23 LCLCLCLVLATLPVALGLANCP---------NGCECDDD---TLMVNCGEGTLDVLPIALNPAIQ 75

  Fly    76 ----THARLKPVD----------LLYVNNSTISELPDAVFS-NLSLHNLQLSSCGIQRIATGAFK 125
                .:.:||.:|          .|.::.:.:..:|:..|: :..|..|.|....|.:::...|.
  Fly    76 RLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFL 140

  Fly   126 GQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT 190
            |. |.:..|||:.||:|::.......:.||..|:|.:|::|||...|..||..|..|.|:||.:|
  Fly   141 GL-STISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLT 204

  Fly   191 ------------------LASNAFR----GLEQSLK---NLNLKGTKQRKVP-ESIRGLKSLAFL 229
                              |.:|:|.    |..|.||   .|:|:|.....:. ::::||.||.||
  Fly   205 TVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFL 269

  Fly   230 DLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLN-NLLAEFP 293
            |||.|.:..:|.|    .|..|..|..||:.:|..:.|...||:|:|: |..|.|.. ..|....
  Fly   270 DLSDNRLPAIPTA----AFQRLGRLEQLNIGQNDFEVISSGAFSGLRE-LRHLELTGAQRLRRVE 329

  Fly   294 IGAVHSLKELRVLDIGFN-LLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSL 357
            .||......|..|::..| .|..|...|..|.|.::.:.|..|.|||:.||....  |.|:.|.|
  Fly   330 SGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPW--ADLQTLDL 392

  Fly   358 GGRFLHCDCKLRWVAEWI--RNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPD----- 415
            ......|||:|.|:...:  ||     .|.:..|..|..|...||.....:....|.|..     
  Fly   393 SENPFECDCRLLWLRHLLVSRN-----ASGQYAPVICAYPTALRDLPLAHLAEPLLGCAHGAASK 452

  Fly   416 --------IADAA-------------------LRGPVGLADNLKPTLPSSPDSVEYETGTGTGTV 453
                    :|.||                   |:|...|....:....:..|. ||.:....|..
  Fly   453 QAIIGILVVACAALITTLALVLYTCRHRIREMLKGHSALGRKEREYQKTFSDE-EYMSRPPPGGG 516

  Fly   454 GTGTAASA-PVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKSTTTI----SATTASPAS 513
            |...||.. |..:..|...               |.|......||.......    .|:|||   
  Fly   517 GVHPAAGGYPYIAGNSRMI---------------PVTELXLEAPPPPQLRGRGGGGGASTAS--- 563

  Fly   514 NPPVNGTGTVQATSITTSSSSSSSSSTSTGH-----GNGKQAPGWRQGVTNGNGNSG-----VGG 568
                   |.||...:.::...:|:|.....|     .||:|....:|..|:...:|.     :..
  Fly   564 -------GAVQQLQVPSAVDQASNSFAQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQQDMRLLAC 621

  Fly   569 AGGLHKP--------QRPPLV-------LGYPPQRGTRI--DDANEVQ 599
            .||  ||        .|||:|       ...|...|.|:  |..|..|
  Fly   622 NGG--KPLNATSLPRHRPPVVQESTLSHYSQPLANGIRLTQDHFNHNQ 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hafNP_001356954.1 LRR <52..>252 CDD:227223 65/244 (27%)
leucine-rich repeat 86..105 CDD:275380 3/19 (16%)
leucine-rich repeat 106..129 CDD:275380 6/22 (27%)
LRR_8 131..189 CDD:338972 22/57 (39%)
leucine-rich repeat 131..154 CDD:275380 6/22 (27%)
leucine-rich repeat 155..178 CDD:275380 10/22 (45%)
leucine-rich repeat 179..202 CDD:275380 10/44 (23%)
leucine-rich repeat 203..225 CDD:275380 7/25 (28%)
leucine-rich repeat 226..253 CDD:275380 11/26 (42%)
LRR_8 254..337 CDD:338972 25/84 (30%)
leucine-rich repeat 254..302 CDD:275380 15/48 (31%)
leucine-rich repeat 303..326 CDD:275380 7/23 (30%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
PCC 332..>413 CDD:188093 25/82 (30%)
PRK10927 <1061..>1097 CDD:236797
capsNP_001303391.1 leucine-rich repeat 75..96 CDD:275380 3/20 (15%)
LRR_8 96..155 CDD:290566 14/59 (24%)
leucine-rich repeat 97..120 CDD:275380 3/22 (14%)
leucine-rich repeat 121..144 CDD:275380 6/23 (26%)
LRR_8 143..201 CDD:290566 21/57 (37%)
leucine-rich repeat 145..168 CDD:275380 6/22 (27%)
LRR_RI 147..397 CDD:238064 81/256 (32%)
leucine-rich repeat 169..192 CDD:275380 10/22 (45%)
leucine-rich repeat 193..217 CDD:275380 6/23 (26%)
LRR_8 217..276 CDD:290566 20/58 (34%)
leucine-rich repeat 218..241 CDD:275380 6/22 (27%)
leucine-rich repeat 242..265 CDD:275380 5/22 (23%)
LRR_8 265..321 CDD:290566 24/60 (40%)
leucine-rich repeat 266..289 CDD:275380 11/26 (42%)
leucine-rich repeat 290..313 CDD:275380 8/22 (36%)
LRR_8 312..374 CDD:290566 17/62 (27%)
leucine-rich repeat 314..335 CDD:275380 6/20 (30%)
leucine-rich repeat 339..363 CDD:275380 7/23 (30%)
LRRCT 395..445 CDD:214507 14/54 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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