DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and Lapsyn

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_611561.1	Gene:	Lapsyn / 37418	FlyBaseID:	FBgn0034602	Length:	343	Species:	Drosophila melanogaster

Alignment Length:	260	Identity:	57/260 - (21%)
Similarity:	107/260 - (41%)	Gaps:	83/260 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 CAY-NLGRELSVQCDQVDFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNLSLHNLQLSS 113
            |.| ::.:.|.::|..:|                          :.|:|..:.|::.:  |.||.
  Fly    31 CTYGHIDKLLRIRCYDLD--------------------------LKEVPQNLKSSVEV--LDLSH 67

  Fly   114 CGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTK 178
            ..|:::.|.:|: :.:.::.|.|.||::..|.|...:.|..|..:|||.|.|:.||.:.| .|.:
  Fly    68 NRIRKLKTSSFQ-RYTDIKFLMLYDNMILSVEVGTFEPLTSLQEIDLSNNGLTTIPLELF-QLPR 130

  Fly   179 LSTLKLNDNNVTLASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAG 243
            |..|.::.|.:|              :|||:.     :.:.||.  .|.:|:::...::|||..|
  Fly   131 LRNLYIDSNELT--------------SLNLQA-----LEKPIRA--PLEYLNVAGCELQELPDLG 174

  Fly   244 GIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDI 308
                  .|..|..||...|.:|:                         |.|.::.::..|:|:|:
  Fly   175 ------ILPKLWQLNASMNPLQN-------------------------FRIDSLANMCHLQVIDL 208

Fly 309 308
Fly 209 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	45/200 (23%)
		leucine-rich repeat	86..105	CDD:275380	3/18 (17%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	20/57 (35%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	4/22 (18%)
		leucine-rich repeat	203..225	CDD:275380	5/21 (24%)
		leucine-rich repeat	226..253	CDD:275380	7/26 (27%)
		LRR_8	254..337	CDD:338972	10/55 (18%)
		leucine-rich repeat	254..302	CDD:275380	7/47 (15%)
		leucine-rich repeat	303..326	CDD:275380	3/6 (50%)
		leucine-rich repeat	327..350	CDD:275380
		PCC	332..>413	CDD:188093
		PRK10927	<1061..>1097	CDD:236797
Lapsyn	NP_611561.1	leucine-rich repeat	39..59	CDD:275380	5/45 (11%)
		LRR_8	58..118	CDD:290566	19/62 (31%)
		leucine-rich repeat	60..83	CDD:275380	6/25 (24%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		LRR_RI	<94..>249	CDD:238064	39/168 (23%)
		LRR_8	106..167	CDD:290566	21/82 (26%)
		LRR_4	106..145	CDD:289563	14/53 (26%)
		leucine-rich repeat	108..130	CDD:275380	10/22 (45%)
		leucine-rich repeat	131..154	CDD:275380	7/41 (17%)
		leucine-rich repeat	157..178	CDD:275380	7/26 (27%)
		leucine-rich repeat	179..202	CDD:275380	7/47 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100