DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and rdo

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	712	Identity:	146/712 - (20%)
Similarity:	232/712 - (32%)	Gaps:	230/712 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAY-NLGRELSVQCDQVDFSQLLAAMNTHARLK 81
            |.::|.:...   ...:||         |.|.|:. :|.|..:: |.:...:.||:.......:|
  Fly    10 LCIMPAMFSN---TKRKCP---------TECQCSMDDLDRYQAI-CTKGGLNSLLSPNELDVDVK 61

  Fly    82 PV---------------------DLLYVNNSTISELPDAVFSNLS-LHNLQLSSCGIQRIATGAF 124
            .:                     ::|.:.:|.:..:....|..|. |..|.||...|..|....|
  Fly    62 VIIIRGPRNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNF 126

  Fly   125 KGQESV-----------------------LRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLS 166
            :||:::                       ||.|||.||.:.::......:|.:|..||||.|.|.
  Fly   127 RGQDNLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQ 191

  Fly   167 HIPDDAFVGLTKLSTLKLND-----------------NNVTLASNAFRGL--------------- 199
            .:..|.|..:.:|..||..:                 :.:.|..|.|:.|
  Fly   192 DLQPDVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVL 256

  Fly   200 ----------------EQSLKNLNLKGTKQRKVP-ESIRGLKSLAFLDLSQNGIKELPGAGGIRV 247
                            ::||.:|:|...:..||| :|...|.:|.|||||.|.:..|. ...||
  Fly   257 LDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLE-PQSIR- 319

  Fly   248 FDGLDALTALNLERNLIQSIGETAFAGVRKTLSSL-------------SLLNNL-------LAEF 292
              .|..|..||:..|::..:.|     :|:|...|             .|:..|       :...
  Fly   320 --SLSNLLTLNISGNVLMDLRE-----MRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTM 377

  Fly   293 PIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSL 357
            |:|.:|..|:||.|:|..|.|.:...........:..|.|..|.|..:.|.....:.. :|.:.|
  Fly   378 PVGLLHPFKQLRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQG-IRNVRL 441

  Fly   358 GGRFLHCD-C----------KLRWVAEW----------------IRNGDLQ--------VTSRER 387
            ....|.|| |          :|:|  :|                |.|.|:.        :|..|:
  Fly   442 DNNPLICDECHMGKLINVVRQLQW--KWDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQ 504

  Fly   388 NPQFCGTPPRFRDRG---------------------------------FYS----IQPEELSCPD 415
            |.  ..|...|.:.|                                 :|:    :...|..|
  Fly   505 NA--ASTSYNFLEHGGLNTLAILGGIIFVLIAVIILSLVACFSKNRARYYTREDHLNGSESKC-- 565

  Fly   416 IADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAA-SAPVTSSVSSSTSTTTPTTT 479
                       |..||:.|..::..:....|.|.|.|:.|..|| :.|.|:....|.|....:|.
  Fly   566 -----------LEKNLEATTITTLGNGSSPTTTTTLTLATSPAAPNGPKTNGQGLSLSPANGSTP 619

  Fly   480 TTTTTAEPTTRRSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITTSSSSSSSSSTS 541
            ....:.:.....:.|.|......||.....||.  ||..........|:..|.|.|.:|:|:
  Fly   620 VHGISDDKGKEINFTFPVDDRVCTIDELMPSPP--PPPQQHPHPNMGSLMYSVSHSPNSATT 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	62/294 (21%)
		leucine-rich repeat	86..105	CDD:275380	3/18 (17%)
		leucine-rich repeat	106..129	CDD:275380	9/22 (41%)
		LRR_8	131..189	CDD:338972	20/74 (27%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..202	CDD:275380	7/70 (10%)
		leucine-rich repeat	203..225	CDD:275380	8/22 (36%)
		leucine-rich repeat	226..253	CDD:275380	11/26 (42%)
		LRR_8	254..337	CDD:338972	23/102 (23%)
		leucine-rich repeat	254..302	CDD:275380	13/67 (19%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		PCC	332..>413	CDD:188093	24/152 (16%)
		PRK10927	<1061..>1097	CDD:236797
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	14/58 (24%)
		leucine-rich repeat	132..155	CDD:275380	0/22 (0%)
		LRR_RI	151..422	CDD:238064	67/279 (24%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		LRR_8	178..262	CDD:290566	16/83 (19%)
		leucine-rich repeat	180..203	CDD:275380	9/22 (41%)
		leucine-rich repeat	204..251	CDD:275380	7/46 (15%)
		leucine-rich repeat	252..275	CDD:275380	0/22 (0%)
		LRR_8	274..334	CDD:290566	24/63 (38%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		LRR_4	298..342	CDD:289563	16/52 (31%)
		leucine-rich repeat	300..323	CDD:275380	11/26 (42%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100