DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and kek3

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster

Alignment Length:	1352	Identity:	245/1352 - (18%)
Similarity:	384/1352 - (28%)	Gaps:	525/1352 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLK 81
            |||.|.....:|....|:||         ..|.|.:..|:| ||.|        |.|..||.. :
  Fly    61 LLLWLLCCCSQLGQLRAECP---------AVCECKWKSGKE-SVLC--------LNANLTHIP-Q 106

  Fly    82 PVD----LLYVNNSTISELPDAVFSNLSLHNLQ---LSSCGIQRIATGAFKGQESVLRNLNLQDN 139
            |:|    ||.::.:.|..:||..|:...|.|||   |:.|.::.|...||:...::: .|:|..|
  Fly   107 PLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLV-ELDLSQN 170

  Fly   140 LLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT-LASNAFRGLEQSL 203
            ||:.:|..||..:.:|..|.||.|.:..:|||||..:.:|..|:|:|..:: :|..||.|||.||
  Fly   171 LLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSL 235

  Fly   204 KNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIG 268
            :
  Fly   236 E---------------------------------------------------------------- 236

  Fly   269 ETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALD 333
                                                                        .|.||
  Fly   237 ------------------------------------------------------------WLKLD 241

  Fly   334 GNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRF 398
            ||.||.|..|....| |:|.||.|.....:|.|.||.:..|:    ||.......|..|.:|||.
  Fly   242 GNRLSEVRSGTITSL-ASLHGLELARNTWNCSCSLRPLRAWM----LQQNIPSGIPPTCESPPRL 301

  Fly   399 RDRGFYSIQPEELSC-PDI--ADAALRGPVGLADNLKPTLPSSPDS-----VEYETGTGTGTVGT 455
            ..|.:..:..::.:| |.|  .|....|..|....:...:...|..     ::..........|.
  Fly   302 SGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGD 366

  Fly   456 GTAASAPVTSSVSSSTST------TTPTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTASPASN 514
            |.:.|.|.|::.:....|      ...:..|..|.........|.....|:....::.|.:.:..
  Fly   367 GDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRR 431

  Fly   515 PP-------VNGTGTVQATSITTSSSSSS-----------------------SSSTSTGHGNGKQ 549
            ||       :...|.|.|..:...||.::                       |.|........:.
  Fly   432 PPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTART 496

  Fly   550 APGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPPQRGTRIDDANEVQVKHAFRQDSSVIIQW 614
            .|....|.:.|.|::  .|||..|..:..    ||.....|.::|.:..|........:....:.
  Fly   497 RPDLGGGASCGGGSA--TGAGLFHDAEEQ----GYLRAAHTPLNDNDAGQAAAIVNPSAGSAQRR 555

  Fly   615 DSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFKIKNVPAQECIIVCVISLEELHVTPETVPY 679
            :.|..::                 ....:..|.:.::.:.|.|:       ...:.|..|....:
  Fly   556 NGDYLHV-----------------STHCDDEEEDQQLHHHPQQQ-------PASQHHPHPNQQQH 596

  Fly   680 QQCREVRTVASQASNMDKITIAASAAICGTIIVAVIVFIAASRRSRKLQSSQQKSP--LPIGGLP 742
            ||.:     .||..     .::||.|                ..|..|:.:....|  :.|||..
  Fly   597 QQRK-----GSQGH-----VVSASGA----------------NNSAPLEETDLHIPRLIDIGGTD 635

  Fly   743 VNCCGPTGSPGPLGSIATLSAFNNHKEWDQVSAYSGRSIPRPRIYPVEQ--PDDMR------SHF 799
               ...:.....:.:.|.|:.:..| .| :.:..:...|..|...||..  |..:.      :|:
  Fly   636 ---SASSSISSQVDAAARLAGYAGH-TW-KTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHY 695

  Fly   800 SGMPG-KVGKSRSLADGQSQHSFSNNSHRGYLGSAFPSNLVNSRPELRQ-SRQSLAAASERMSRA 862
            ...|. ::..|...::||....|.:|                 .|:|.. ::.::|.|.:.....
  Fly   696 GNHPADEMATSVFCSEGQESDLFDSN-----------------YPDLLDIAKYAVAQAQQEGRGQ 743

  Fly   863 SYAGSIHGGNGGGGGLGGNGGGGGNGLPVSSLMAMSGMVGGGGPASIASSARRSRPRSRSREQLN 927
            .||.:....|||                   |..:        |..:.:|.:..|..|.|:..|
  Fly   744 GYAQATTTPNGG-------------------LCTL--------PRKLKTSGKYFRNSSDSQSPL- 780

  Fly   928 TTHIHNHRPGSRYSQAGSTHTLNNYCDTSDNWTDHDMDIYMARNPTTRNGLVPLXGRLTLSXYFN 992
                                       .:||.:.:                    |..||.
  Fly   781 ---------------------------LADNSSKY--------------------GSSTLG---- 794

  Fly   993 VVLNWDGIFXQYLTPTIEGTEGRGRGRRQQQQQQQQQQQQQQQHQQLQHQQQQQHQHQLQQLRNE 1057
                 ||.|.         .|..|.|||...
  Fly   795 -----DGSFL---------NEAMGLGRRYSA---------------------------------- 811

  Fly  1058 RHQQRHRNDQQWEQPYQPAQQQHQRLQYYMPQTERCTSPPDVVPRAANFHNSNTTSTGHNDNSNS 1122
                        |..|                              ||: :|..|.||....:||
  Fly   812 ------------ESSY------------------------------ANY-SSTATYTGGGQRANS 833

  Fly  1123 H------------------GSSSSSSSNIAQQQQAPLAAMTAALGDATAAATAAAAAAASAS--- 1166
            .                  |...|..|:..|.|::..:|.|..|..:..|:.||.||..|.:
  Fly   834 FLNLVQSGAHQGKLLPSHLGQKPSLPSSPVQHQRSLSSAATPLLDFSALASRAAGAANTSVAAYD 898

  Fly  1167 --GIVVENYFNEY-----------ERQEIIYHHPTSRRSSSSSSSCSAA------ATRHVPRSNA 1212
              ...:|.:..||           |..:.|....|..|.:...|:...|      |..|.|:.
  Fly   899 YHAAQLERFLEEYRNLQDQLCKMKETCDTIRKKETPLRVAIGQSAAQLADPVMYSAASHSPKP-- 961

  Fly  1213 FRLQLPAVATATT-----------------NNILYNISNKHGATGHNGSIGN 1247
                 ||.:...|                 .|.:....|..|:.|.|||.|:
  Fly   962 -----PATSNLKTKTLLPGQPPDPPPYWLHRNAMLKRLNGDGSAGTNGSGGS 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	56/207 (27%)
		leucine-rich repeat	86..105	CDD:275380	5/18 (28%)
		leucine-rich repeat	106..129	CDD:275380	9/25 (36%)
		LRR_8	131..189	CDD:338972	22/57 (39%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	10/23 (43%)
		leucine-rich repeat	203..225	CDD:275380	1/21 (5%)
		leucine-rich repeat	226..253	CDD:275380	0/26 (0%)
		LRR_8	254..337	CDD:338972	5/82 (6%)
		leucine-rich repeat	254..302	CDD:275380	0/47 (0%)
		leucine-rich repeat	303..326	CDD:275380	0/22 (0%)
		leucine-rich repeat	327..350	CDD:275380	10/22 (45%)
		PCC	332..>413	CDD:188093	27/80 (34%)
		PRK10927	<1061..>1097	CDD:236797	2/35 (6%)
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	60/282 (21%)
		leucine-rich repeat	112..137	CDD:275380	7/24 (29%)
		LRR_8	137..196	CDD:290566	21/59 (36%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..185	CDD:275380	8/23 (35%)
		LRR_8	184..245	CDD:290566	27/184 (15%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	10/23 (43%)
		leucine-rich repeat	235..258	CDD:275380	11/147 (7%)
		LRRCT	267..316	CDD:214507	13/52 (25%)
		IG_like	328..428	CDD:214653	14/99 (14%)
		Ig	335..425	CDD:143165	11/89 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100