DRSC/TRiP Functional Genomics Resources

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Protein Alignment haf and Islr2

DIOPT Version :9

Sequence 1:NP_001356954.1 Gene:haf / 33339 FlyBaseID:FBgn0261509 Length:1347 Species:Drosophila melanogaster
Sequence 2:NP_001155007.1 Gene:Islr2 / 320563 MGIID:2444277 Length:789 Species:Mus musculus


Alignment Length:513 Identity:118/513 - (23%)
Similarity:181/513 - (35%) Gaps:122/513 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 RKVPESIRGLKSLAFLDLSQNGIKEL-PGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRK 277
            |:|||.:..  ::..|.||.|.|..| .||     |..:..:|:|.|..:.::::...|.| |..
Mouse    87 REVPEGLPA--NVTTLSLSANKITVLRRGA-----FVNVTQVTSLWLAHSEVRTVESGALA-VLS 143

  Fly   278 TLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPE 342
            .|.:|.|.:||::.||...:.:|..|::|.:..|.|.|||..|....|.:..|.::.|.|.::..
Mouse   144 QLKNLDLSHNLISNFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLEP 208

  Fly   343 GAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSI- 406
            |.|..|:| |..|.|.....||.|.|.|:..|.  ...:|:..|.:...|.:||..:....:.: 
Mouse   209 GTFDALSA-LSHLQLYHNPFHCSCGLVWLQAWA--ASTRVSLPEPDSIACASPPELQGVPVHRLP 270

  Fly   407 ---------------QPEELSCPDIADAA------------------LRGPVGLADNLKPTLPSS 438
                           .||....|..|..|                  |:.|.|....:.|.|...
Mouse   271 ALPCAPPSVRLSAEPPPEAPGTPLRAGLAFMLHCVAEGHPTPRLQWQLQIPGGTVVLVPPVLSKE 335

  Fly   439 PDSVE-YETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPT-------------- 488
            .|..: .|.|.|.|.....|...||          |.||........|.|.              
Mouse   336 EDGGDKVEDGEGDGDEDLPTQTEAP----------TPTPAPAWPAPPATPRFLALANGSLLVPLL 390

  Fly   489 --------TRRSTTRPPTKSTT-TISATTASPASNPPVNGTGTVQATSITTSSSSSSSSSTSTGH 544
                    |.|:.....|.||: .::...|.|..:.|  |||......:.|    |...:|:.|.
Mouse   391 SAKEAGIYTCRAHNELGTNSTSLRVTVAAAGPPKHAP--GTGEEPDAQVPT----SERKATTKGR 449

  Fly   545 GNGKQAPGWRQGVTNGNGNSGVGGAGGLH------------KPQRPPLVLGYPPQRGTRIDDANE 597
            .| ...|...:|.|.|.|.:.|...|.:.            :.|.|...:|   ::.....|.:.
Mouse   450 SN-SVLPFKPEGKTKGQGLARVSVLGEIEAELEETDEGEQMEGQIPADPMG---EKHCGHGDPSR 510

  Fly   598 VQVKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFKIKNVP 655
            ....|||.|.|.:       ..::....|:             .|:.:|||.:::..|
Mouse   511 YVSNHAFNQSSDL-------KPHVFELGVI-------------ALDVAEREARVQLTP 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hafNP_001356954.1 LRR <52..>252 CDD:227223 13/38 (34%)
leucine-rich repeat 86..105 CDD:275380
leucine-rich repeat 106..129 CDD:275380
LRR_8 131..189 CDD:338972
leucine-rich repeat 131..154 CDD:275380
leucine-rich repeat 155..178 CDD:275380
leucine-rich repeat 179..202 CDD:275380
leucine-rich repeat 203..225 CDD:275380 4/10 (40%)
leucine-rich repeat 226..253 CDD:275380 9/27 (33%)
LRR_8 254..337 CDD:338972 25/82 (30%)
leucine-rich repeat 254..302 CDD:275380 14/47 (30%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 6/22 (27%)
PCC 332..>413 CDD:188093 22/96 (23%)
PRK10927 <1061..>1097 CDD:236797
Islr2NP_001155007.1 leucine-rich repeat 80..96 CDD:275380 4/10 (40%)
LRR_8 96..155 CDD:290566 19/64 (30%)
leucine-rich repeat 97..120 CDD:275380 9/27 (33%)
leucine-rich repeat 121..144 CDD:275380 6/23 (26%)
LRR_4 144..183 CDD:289563 13/38 (34%)
leucine-rich repeat 145..168 CDD:275380 8/22 (36%)
LRR_8 164..227 CDD:290566 20/63 (32%)
LRR_4 169..208 CDD:289563 12/38 (32%)
leucine-rich repeat 169..192 CDD:275380 8/22 (36%)
leucine-rich repeat 193..216 CDD:275380 6/22 (27%)
LRRCT 225..273 CDD:214507 11/49 (22%)
Ig_2 288..417 CDD:290606 27/138 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24366
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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