DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and Lrig3

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_796126.4	Gene:	Lrig3 / 320398	MGIID:	2443955	Length:	1117	Species:	Mus musculus

Alignment Length:	895	Identity:	196/895 - (21%)
Similarity:	325/895 - (36%)	Gaps:	226/895 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LPLILGRLHVAHAQCPWQRDVPDLQTSCICAY-----------------NLG------RELSVQC 62
            ||..:.||.::|.:..:      :|||.:...                 |||      |:||:..
Mouse    72 LPAWVTRLDLSHNRLSF------IQTSSLSHLQSLQEVKLNNNELETIPNLGSISANIRQLSLAG 130

  Fly    63 DQVD------------FSQLLAAMNTHARLK----PVDL--LYVNNSTISELPDAVFSNL--SLH 107
            :.:|            ...|..:.|..:.|:    |:.|  ||:||:.:|.:....|.||  :|.
Mouse   131 NAIDKILPEQLEAFQSLETLDLSNNNISELRTAFPPLQLKYLYINNNRVSSMEPGYFDNLASTLL 195

  Fly   108 NLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDA 172
            .|:|:...|..|....||..:  |::|.|..|.:.:|.....:.||.|..|.:.:|.::.:.|.|
Mouse   196 VLKLNRNRISAIPPKMFKLPQ--LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGA 258

  Fly   173 FVGLTKLSTLKLNDNNVT-LASNAFRGLEQSLKNLNLKGTKQRKV-PESIRGLKSLAFLDLSQNG 235
            |.||:.:..|:|:.||:| :......|| ..|:.|:|......:: |::....:.|:.|||:.|.
Mouse   259 FWGLSNMEVLQLDHNNLTEITKGWLYGL-LMLRELHLSQNAINRISPDAWEFCQKLSELDLTFNH 322

  Fly   236 IKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLA---EFPIGAV 297
            :..|..:.    |.||..|.||::..|.:..|.:.||.|: .:|.:|.|.||.::   |...||.
Mouse   323 LSRLDDSS----FLGLSLLNALHIGNNKVSYIADCAFRGL-TSLKTLDLRNNEISWTIEDMSGAF 382

  Fly   298 HSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFL 362
            ..|..||.|.:..|.:.|:.:.||.|...:..|.|.||.:.|:...||:.:. .|:.|.|....|
Mouse   383 SGLDRLRQLILQGNRIRSITKKAFAGLDTLEHLDLSGNAIMSLQSNAFSQMK-KLQQLHLNTSSL 446

  Fly   363 HCDCKLRWVAEWIRNGDLQ--VTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPV 425
            .|||:|||:.:|:...:.|  |.:.      |..|...:.|..:::.|:...|.|..
Mouse   447 LCDCQLRWLPQWVAENNFQSFVNAS------CAHPQLLKGRSIFTVSPDGFVCDDFP-------- 497

  Fly   426 GLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTR 490
                  ||.:...|:       |.:...|:..:.:.   |:.|||.|..|..........:....
Mouse   498 ------KPQITVQPE-------TQSAIKGSDVSFTC---SAASSSDSPMTFAWKKDNEALQDAEM 546

  Fly   491 RSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITTSSSSSSS-----------SSTST-- 542
            .:......:....:..||.....|......|..|.. |:....||.|           |.|.|
Mouse   547 ENYAHLRAQGGELMEYTTILRLRNVEFTSEGKYQCV-ISNHFGSSYSVKAKLTINMLPSFTKTPM 610

  Fly   543 -----------------GH---------GNGKQAPGWRQ----------------------GVTN 559
                             ||         ..|...|..|:                      ||.:
Mouse   611 DLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 675

  Fly   560 GNGNSGVGGAGG------LHKPQ--RPPL----------VL-----GYPPQR--GTRIDDANEVQ 599
            ....:..|....      |..|.  ||.|          ||     |.||.|  .|:.|....|.
Mouse   676 CTAQNSAGSVSANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPRLNWTKDDSPLVVT 740

  Fly   600 VKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFKIKNVPAQECIIVCV 664
            .:|.|...:.::|..|||.::.          |:...:....|.:.....::..:|...|
Mouse   741 ERHFFAAGNQLLIIVDSDVSDA----------GKYTCEMSNTLGTERGNVRLSVIPTPTC----- 790

  Fly   665 ISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASAAICGTIIVAVIVFIAASRRSRKLQ- 728
               :..|:|..::.          ....:.:..:.||....:.||.:|.|::.....||:....
Mouse   791 ---DSPHMTAPSLD----------GDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSI 842

  Fly   729 SSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHKEWDQVSAYSG 778
            ::..::.|           |...|..|.|..||:    .::...:|:.||
Mouse   843 TNTDETNL-----------PADIPSYLSSQGTLA----DRQDGYISSESG 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	61/244 (25%)
		leucine-rich repeat	86..105	CDD:275380	8/20 (40%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		LRR_8	131..189	CDD:338972	18/57 (32%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..202	CDD:275380	7/23 (30%)
		leucine-rich repeat	203..225	CDD:275380	4/22 (18%)
		leucine-rich repeat	226..253	CDD:275380	9/26 (35%)
		LRR_8	254..337	CDD:338972	29/85 (34%)
		leucine-rich repeat	254..302	CDD:275380	17/50 (34%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	23/82 (28%)
		PRK10927	<1061..>1097	CDD:236797
Lrig3	NP_796126.4	LRR 1	75..98		6/28 (21%)
		LRR_8	76..133	CDD:290566	12/62 (19%)
		leucine-rich repeat	76..99	CDD:275378	6/28 (21%)
		LRR_RI	81..324	CDD:238064	62/251 (25%)
		LRR 2	99..120		3/20 (15%)
		leucine-rich repeat	100..146	CDD:275378	7/45 (16%)
		LRR_8	122..179	CDD:290566	13/56 (23%)
		LRR 3	122..143		4/20 (20%)
		LRR 4	146..168		4/21 (19%)
		leucine-rich repeat	147..168	CDD:275380	4/20 (20%)
		LRR_8	168..227	CDD:290566	20/60 (33%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		LRR 5	169..189		7/19 (37%)
		LRR 6	193..214		6/20 (30%)
		leucine-rich repeat	194..216	CDD:275380	7/21 (33%)
		LRR_8	215..275	CDD:290566	18/61 (30%)
		LRR 7	216..237		5/22 (23%)
		leucine-rich repeat	217..240	CDD:275380	6/22 (27%)
		LRR 8	240..261		6/20 (30%)
		leucine-rich repeat	241..264	CDD:275380	8/22 (36%)
		LRR_RI	262..>446	CDD:238064	56/190 (29%)
		LRR_8	263..323	CDD:290566	16/60 (27%)
		LRR 9	264..285		5/20 (25%)
		leucine-rich repeat	265..288	CDD:275380	7/23 (30%)
		LRR 10	288..309		4/20 (20%)
		leucine-rich repeat	289..312	CDD:275380	4/22 (18%)
		LRR_8	312..371	CDD:290566	22/63 (35%)
		LRR 11	312..333		7/24 (29%)
		leucine-rich repeat	313..336	CDD:275380	9/26 (35%)
		LRR 12	336..357		7/20 (35%)
		leucine-rich repeat	337..360	CDD:275380	8/23 (35%)
		LRR_8	359..422	CDD:290566	21/62 (34%)
		LRR 13	360..382		7/21 (33%)
		leucine-rich repeat	361..385	CDD:275380	8/23 (35%)
		LRR 14	387..408		7/20 (35%)
		leucine-rich repeat	388..411	CDD:275380	8/22 (36%)
		LRR 15	411..432		7/20 (35%)
		leucine-rich repeat	412..433	CDD:275380	7/20 (35%)
		LRRCT	446..494	CDD:214507	14/53 (26%)
		I-set	499..599	CDD:254352	19/110 (17%)
		Ig	500..587	CDD:299845	15/97 (15%)
		I-set	603..693	CDD:254352	11/89 (12%)
		Ig_1	620..694	CDD:143240	8/73 (11%)
		I-set	697..784	CDD:254352	21/96 (22%)
		IGc2	711..774	CDD:197706	16/72 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910