DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and Rtn4rl2

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_852045.1	Gene:	Rtn4rl2 / 311169	RGDID:	727797	Length:	420	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	128/549 - (23%)
Similarity:	188/549 - (34%)	Gaps:	173/549 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPG-RTTTALPAATTPLLLLLPLILGRLHVAHAQCPWQRDVPDLQTSC--IC-AYNLGRELSVQ 61
            |.|| |.....||:...||.||.|                  |.:..||  :| .|:  ...:|.
  Rat     1 MLPGLRRLLQGPASACLLLTLLAL------------------PPVTPSCPMLCTCYS--SPPTVS 45

  Fly    62 CDQVDFSQLLAAMNTHARLKPVDL------LYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIA 120
            |...:||.:           |:.|      |::.|:.|..|....|.. :|..|.|.|..:..|.
  Rat    46 CQANNFSSV-----------PLSLPPSTQRLFLQNNLIRSLRPGTFGP-NLLTLWLFSNNLSTIY 98

  Fly   121 TGAFKGQESVLRNLNLQDNL-LADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKL 184
            .|.|:..:: |..|:|.||. |..:..:..:.|.:|..|.|.:.|||.:|.:.|.||..|..|.|
  Rat    99 PGTFRHLQA-LEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYL 162

  Fly   185 NDNNVT-LASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVF 248
            .:|::. |..:.|..| .:|.:|.|.|.:.|.:.|                           .||
  Rat   163 QENSLLHLQDDLFADL-ANLSHLFLHGNRLRLLTE---------------------------HVF 199

  Fly   249 DGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLL 313
            .||.:|..|.|..|.:|.:...||.|:.: |:.|.|.||.||
  Rat   200 RGLGSLDRLLLHGNRLQGVHRAAFHGLSR-LTILYLFNNSLA----------------------- 240

  Fly   314 TSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNG 378
             |||..|....|.:..|.|:.||.:                         |||:.|.:..|.:..
  Rat   241 -SLPGEALADLPALEFLRLNANPWA-------------------------CDCRARPLWAWFQRA 279

  Fly   379 DLQVTSRERNPQFCGTPPRFRDRGFYSIQPEEL-SCPDIADAALRGPVGLADNLKPTLPSSPDSV 442
              :|:|.:..   |.|||..:.|...:::..:. :||                  |..|:.|.|.
  Rat   280 --RVSSSDVT---CATPPERQGRDLRTLRDTDFQACP------------------PPTPTRPGSR 321

  Fly   443 EYETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTK-------- 499
            .....:.....|...|.:.|           ..|:|......||.:..|.....||:
  Rat   322 ARGNSSSNHLYGVAEAGAPP-----------ADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYG 375

  Fly   500 ------STTTISATTASPA-SNPPVNGTG 521
                  ..|...|...:|| |..||...|
  Rat   376 GEDQRGEQTCPGAACQAPADSRGPVLSAG 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	52/207 (25%)
		leucine-rich repeat	86..105	CDD:275380	5/18 (28%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		LRR_8	131..189	CDD:338972	21/58 (36%)
		leucine-rich repeat	131..154	CDD:275380	7/23 (30%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	7/23 (30%)
		leucine-rich repeat	203..225	CDD:275380	6/21 (29%)
		leucine-rich repeat	226..253	CDD:275380	4/26 (15%)
		LRR_8	254..337	CDD:338972	23/82 (28%)
		leucine-rich repeat	254..302	CDD:275380	15/47 (32%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		PCC	332..>413	CDD:188093	15/81 (19%)
		PRK10927	<1061..>1097	CDD:236797
Rtn4rl2	NP_852045.1	LRR_8	60..117	CDD:290566	16/58 (28%)
		LRR 1	61..82		5/20 (25%)
		leucine-rich repeat	62..83	CDD:275380	5/21 (24%)
		LRR 2	83..104		7/20 (35%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		LRR_RI	103..>261	CDD:238064	56/211 (27%)
		LRR 3	107..129		6/22 (27%)
		LRR_8	108..167	CDD:290566	21/58 (36%)
		leucine-rich repeat	108..132	CDD:275380	7/23 (30%)
		LRR 4	132..153		8/20 (40%)
		leucine-rich repeat	133..156	CDD:275380	10/22 (45%)
		LRR_8	156..215	CDD:290566	21/86 (24%)
		LRR 5	156..177		6/20 (30%)
		leucine-rich repeat	157..180	CDD:275380	7/23 (30%)
		LRR 6	180..201		8/47 (17%)
		leucine-rich repeat	181..204	CDD:275380	10/49 (20%)
		LRR_8	204..262	CDD:290566	22/82 (27%)
		LRR 7	204..225		7/20 (35%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		LRR 8	228..249		11/45 (24%)
		leucine-rich repeat	229..252	CDD:275380	11/46 (24%)
		TPKR_C2	261..311	CDD:301599	14/79 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..390		23/135 (17%)
		Important for interaction with MAG. /evidence=ECO:0000269\|PubMed:19420245	315..327		3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910