DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and Lrig2

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001101180.1	Gene:	Lrig2 / 310753	RGDID:	1309554	Length:	1054	Species:	Rattus norvegicus

Alignment Length:	947	Identity:	200/947 - (21%)
Similarity:	334/947 - (35%)	Gaps:	222/947 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNLSLHNLQ 110
            |.....:||..|::.:           |...::.|:.:||   :::.|||:..:.|..:||..|.
  Rat   122 TQLSLVHNLIPEINAE-----------AFQLYSALESLDL---SSNIISEIKTSSFPRMSLKYLN 172

  Fly   111 LSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVG 175
            ||:..|..:..|.|......|..:.|..|.::.:|.:..| |..|..|:|.:|::..:....|.|
  Rat   173 LSNNRITTLEAGCFDNLSGSLLVVKLNRNRISMIPPKVFK-LPHLQFLELKRNRIKIVEGLTFQG 236

  Fly   176 LTKLSTLKLNDNNVT-LASNAFRGL----EQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNG 235
            |..|.:||:..|.:: |...||.||    |..|::.||.|..:    ..:.||:.|..|.:|||.
  Rat   237 LDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTGVHK----GWLYGLRMLQQLYVSQNA 297

  Fly   236 IKEL-PGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHS 299
            |::: |.|     ::....|:||:|..|.:..:.|:||.|: ..|..|:|.:|.:.....|....
  Rat   298 IEKISPDA-----WEFCQRLSALDLSYNQLTRLDESAFVGL-SLLERLNLGDNRVTHIADGVFRF 356

  Fly   300 LKELRVLDIGFNLLTSLPEAA---FRGNPGITLLALDGNPLSSVPEGAFAHLNAT---------- 351
            |..|:.||:..|.::...|.|   |.|...:|.|.|.||.:.||.:.||..|.:.
  Rat   357 LSNLQTLDLRNNEISWAIEDASEVFSGLKSLTKLILQGNRIKSVTQKAFVGLESLEYLDLNNNAI 421

  Fly   352 ------------LRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFY 404
                        |:.|.|....|.|||.|:|:.:|:.:.:...:....    |..|.....:...
  Rat   422 MSIQENAFSQTHLKELVLNTSSLLCDCHLKWLLQWLVDNNFHHSVNVS----CAHPEWLAGQSIL 482

  Fly   405 SIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSVSS 469
            ::..::..|.|.              |||.:.:.|::             |.......||...::
  Rat   483 NVDLKDFVCDDF--------------LKPQIRTHPEN-------------TVALRGVNVTLMCTA 520

  Fly   470 STSTTTPTTTTTTTTAE---PTTRRSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITTS 531
            .:|:.:|.:|.....:|   .....:..|...:....:..|:.....:  ||.|...:...|.|:
  Rat   521 VSSSDSPMSTLWRKDSEILYDVDIENFVRYRQQDGEALEYTSVLRLFS--VNFTDEGKYQCIVTN 583

  Fly   532 SSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGV-----GGAGGLHKPQRPPLVLGYPPQRGTR 591
            ...|:.|..:....|  :.|.:.:...:....:|.     ..|.|...||     :.:....||.
  Rat   584 HFGSNYSQKAKLTVN--EMPSFLKTPMDLTIRTGAMARLECAAEGHPTPQ-----ISWQKDGGTD 641

  Fly   592 IDDANEVQVKHAFRQDSSVIIQ---------WDSDTANILG---------------------FRV 626
            ...|.|.:: |...:|....|.         :.....||.|                     .:.
  Rat   642 FPAARERRM-HVMPEDDVFFIANVKIEDMGIYSCMAQNIAGGLSANASLTVLETPSFIRPLEDKT 705

  Fly   627 VYRLFGEKAF----------------KQGPPLESSEREF-------------KIKNVPAQECIIV 662
            |.|  ||.|.                |...||..:||.|             .:::.....|::.
  Rat   706 VTR--GETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCLMS 768

  Fly   663 CVISLEELHVTPETVPYQQC-REVRTVASQASNMDKITIAASAAIC---GTIIVAVIVFIAASRR 723
            ..:..|..|:....:....| ....::..:......:.|.....:|   ||.::.||| |...||
  Rat   769 NTLGTERGHIYLNVISSPNCDSSQNSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIV-IYHMRR 832

  Fly   724 SRKLQSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLS----AFNN-----------------H 767
            ..:..|......|.:         |...|..|.|..|||    .::|                 |
  Rat   833 KDEDYSITNTEELNL---------PADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPASGYTH 888

  Fly   768 KE--------------WDQVSAYSGRSIPRPRIYPVEQPDDMRSHFSG----MPGKVGKSRSLAD 814
            |.              :|..:.||......|..|..|: |.:....|.    ||.:...|....|
  Rat   889 KGTDGGTGTRVICSDCYDNANIYSRTREYCPYTYIAEE-DALDQALSSLMVQMPKETFLSHPPQD 952

  Fly   815 GQSQHSFSNNSHRGYLGSAFPSNLVNSRPELRQSRQS 851
            ..:..|....:.|..  ||||:|...:...|..|::|
  Rat   953 AANLESLMPPTEREL--SAFPTNHERTSENLPFSQRS 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	56/205 (27%)
		leucine-rich repeat	86..105	CDD:275380	4/18 (22%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		LRR_8	131..189	CDD:338972	17/57 (30%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	10/27 (37%)
		leucine-rich repeat	203..225	CDD:275380	6/21 (29%)
		leucine-rich repeat	226..253	CDD:275380	8/27 (30%)
		LRR_8	254..337	CDD:338972	28/85 (33%)
		leucine-rich repeat	254..302	CDD:275380	15/47 (32%)
		leucine-rich repeat	303..326	CDD:275380	8/25 (32%)
		leucine-rich repeat	327..350	CDD:275380	10/22 (45%)
		PCC	332..>413	CDD:188093	20/102 (20%)
		PRK10927	<1061..>1097	CDD:236797
Lrig2	NP_001101180.1	LRR_RI	<50..204	CDD:238064	23/95 (24%)
		leucine-rich repeat	98..120	CDD:275380
		LRR_8	119..178	CDD:290566	17/69 (25%)
		leucine-rich repeat	121..144	CDD:275380	5/32 (16%)
		LRR_RI	136..398	CDD:238064	81/286 (28%)
		leucine-rich repeat	145..167	CDD:275380	7/24 (29%)
		LRR_8	167..226	CDD:290566	18/59 (31%)
		leucine-rich repeat	168..192	CDD:275380	7/23 (30%)
		leucine-rich repeat	193..215	CDD:275380	6/22 (27%)
		leucine-rich repeat	216..239	CDD:275380	7/22 (32%)
		LRR_8	239..298	CDD:290566	21/62 (34%)
		leucine-rich repeat	240..263	CDD:275380	9/22 (41%)
		leucine-rich repeat	264..287	CDD:275380	7/26 (27%)
		leucine-rich repeat	288..311	CDD:275380	8/27 (30%)
		LRR_8	311..370	CDD:290566	19/59 (32%)
		leucine-rich repeat	312..335	CDD:275380	9/23 (39%)
		leucine-rich repeat	336..359	CDD:275380	6/22 (27%)
		LRR_8	358..421	CDD:290566	18/62 (29%)
		leucine-rich repeat	360..384	CDD:275380	7/23 (30%)
		LRR_4	385..426	CDD:289563	10/40 (25%)
		leucine-rich repeat	387..410	CDD:275380	10/22 (45%)
		leucine-rich repeat	411..433	CDD:275380	0/21 (0%)
		LRRCT	444..492	CDD:214507	9/51 (18%)
		Ig	501..597	CDD:299845	17/110 (15%)
		IG	503..597	CDD:214652	17/108 (16%)
		I-set	601..691	CDD:254352	16/95 (17%)
		Ig_1	618..692	CDD:143240	14/79 (18%)
		I-set	695..782	CDD:254352	14/88 (16%)
		Ig	713..782	CDD:299845	9/68 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910