DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and Lgr5

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001100254.1	Gene:	Lgr5 / 299802	RGDID:	1307733	Length:	907	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	112/352 - (31%)
Similarity:	157/352 - (44%)	Gaps:	58/352 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLLLPLILG----RLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQL---LAAM 74
            ||.||.|:..    |.......||         :.|.|..:....|.|.|..:..|:|   |:..
  Rat    12 LLALLQLVAAGSPPRPDTMPRGCP---------SYCHCELDGRMLLRVDCSDLGLSELPSNLSVF 67

  Fly    75 NTHARLKPVDLLYVNNSTISELPDAVFSNLS-LHNLQLSSCGIQRIATGAFKGQESVLRNLNLQD 138
            .::..|.      :||  ||:||.::...|. |..|:|:...:..|..|||.|..| |:.|.||:
  Rat    68 TSYLDLS------MNN--ISQLPASLLHRLRFLEELRLAGNALTHIPKGAFAGLHS-LKVLMLQN 123

  Fly   139 NLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASNAFRGLEQSL 203
            |.|..||.|||:.|..|..|.|..|.:|::|...|.||..|..|.|:||.:|
  Rat   124 NQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALT------------- 175

  Fly   204 KNLNLKGTKQRKVP-ESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSI 267
                       .|| ::.|.|.:|..:.|:.|.|..:..    ..|..|.:|..|:|..|.|.|:
  Rat   176 -----------DVPVQAFRSLSALQAMTLALNKIHHIAD----HAFGNLSSLVVLHLHNNRIHSL 225

  Fly   268 GETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLAL 332
            |:..|.|:. :|.:|.|..|.|.|||. |:.:|..|:.|....|.:.|:||.||.|||.:..:..
  Rat   226 GKKCFDGLH-SLETLDLNYNNLDEFPT-AIKTLSNLKELGFHSNNIRSIPERAFVGNPSLITIHF 288

  Fly   333 DGNPLSSVPEGAFAHLNATLRGLSLGG 359
            ..||:..|...||.|| ..||.|:|.|
  Rat   289 YDNPIQFVGISAFQHL-PELRTLTLNG 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	59/204 (29%)
		leucine-rich repeat	86..105	CDD:275380	6/18 (33%)
		leucine-rich repeat	106..129	CDD:275380	8/22 (36%)
		LRR_8	131..189	CDD:338972	26/57 (46%)
		leucine-rich repeat	131..154	CDD:275380	12/22 (55%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..202	CDD:275380	6/22 (27%)
		leucine-rich repeat	203..225	CDD:275380	4/22 (18%)
		leucine-rich repeat	226..253	CDD:275380	6/26 (23%)
		LRR_8	254..337	CDD:338972	31/82 (38%)
		leucine-rich repeat	254..302	CDD:275380	19/47 (40%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	12/28 (43%)
		PRK10927	<1061..>1097	CDD:236797
Lgr5	NP_001100254.1	LRRNT	33..70	CDD:214470	10/45 (22%)
		LRR 1	44..64		5/19 (26%)
		LRR 2	65..88		7/30 (23%)
		leucine-rich repeat	68..91	CDD:275380	8/30 (27%)
		LRR_RI	88..372	CDD:238064	89/259 (34%)
		LRR 3	89..112		8/22 (36%)
		LRR_8	92..150	CDD:290566	25/58 (43%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		LRR 4	114..136		12/22 (55%)
		leucine-rich repeat	116..139	CDD:275380	12/22 (55%)
		LRR 5	137..160		8/22 (36%)
		LRR_8	138..198	CDD:290566	22/83 (27%)
		leucine-rich repeat	140..163	CDD:275380	9/22 (41%)
		LRR 6	162..184		8/45 (18%)
		leucine-rich repeat	164..187	CDD:275380	10/46 (22%)
		LRR 7	186..208		5/25 (20%)
		LRR_8	188..246	CDD:290566	19/62 (31%)
		leucine-rich repeat	188..211	CDD:275380	6/26 (23%)
		LRR 8	209..232		9/22 (41%)
		leucine-rich repeat	212..235	CDD:275380	9/23 (39%)
		LRR 9	233..256		9/24 (38%)
		leucine-rich repeat	236..258	CDD:275380	10/22 (45%)
		LRR_8	257..314	CDD:290566	22/57 (39%)
		LRR 10	257..279		8/21 (38%)
		leucine-rich repeat	259..282	CDD:275380	10/22 (45%)
		LRR 11	281..303		6/21 (29%)
		leucine-rich repeat	283..304	CDD:275380	5/20 (25%)
		LRR 12	304..327		6/12 (50%)
		leucine-rich repeat	307..353	CDD:275380	5/8 (63%)
		LRR 13	328..350
		LRR 14	351..375
		LRR_8	352..410	CDD:290566
		leucine-rich repeat	354..375	CDD:275380
		leucine-rich repeat	376..399	CDD:275380
		LRR 15	377..396
		LRR 16	397..420
		leucine-rich repeat	400..423	CDD:275380
		LRR 17	422..444
		leucine-rich repeat	445..467	CDD:275378
		LRR 18	564..585
		7tm_1	575..820	CDD:278431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000