DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and Lrrtm3

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001099857.1	Gene:	Lrrtm3 / 294380	RGDID:	1304866	Length:	582	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	101/463 - (21%)
Similarity:	175/463 - (37%)	Gaps:	129/463 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEAL 149
            ::|..:..:.|:|.::.:.....:|:.:|  :|::....|||
  Rat    44 MVYCESQKLQEIPSSISAGCLGLSLRYNS--LQKLKYNQFKG----------------------- 83

  Fly   150 KVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT-LASNAFRGLEQSLKNLNLKGTKQ 213
              |.:|..|.|..|.:|:|.::||.|:.:|..|.|:.|.:: ..:|.||.: .:|:||:|...:.
  Rat    84 --LNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPV-TNLRNLDLSYNQL 145

  Fly   214 RKV-PESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRK 277
            ..: .|..|||:.|..|.|..|.::.:|    :|:|.....|..|:|..|.|:|:....|||:.:
  Rat   146 HSLGSEQFRGLRKLLSLHLRSNSLRTIP----VRIFQDCRNLELLDLGYNRIRSLARNVFAGMIR 206

  Fly   278 TLSSLSLLNNL-----LAEFP-----------------IGAVHS--LKELRVLDIGFNLLTSLP- 317
             |..|.|.:|.     ||.||                 ||...|  ...|:.||:..|.:.:..
  Rat   207 -LKELHLEHNQFSKLNLALFPRLVSLQNLYMQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSG 270

  Fly   318 EAAFRGNPGITLLALDGNPLSSVPEGAFAHLNA--TLRGLSLGGRFLHCDCKLRWVAEWIRNGDL 380
            .:.|:..|.:..|.||.|.|:.:.:..   |::  :|..:||.|....|...:..:..|:::
  Rat   271 PSVFQCVPNLQRLNLDSNKLTFIGQEI---LDSWISLNDISLAGNIWECSRNICSLVNWLKS--- 329

  Fly   381 QVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYE 445
                      |.|    .|:.......|:||...::.||
  Rat   330 ----------FKG----LRENTILCASPKELQGVNVIDA-------------------------- 354

  Fly   446 TGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKS----TTTISA 506
                             |.:......||||..........:||.:....||..:|    ..|:.|
  Rat   355 -----------------VKNYSICGKSTTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGA 402

  Fly   507 TTASPASN 514
            :..||.::
  Rat   403 SEPSPETD 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	41/168 (24%)
		leucine-rich repeat	86..105	CDD:275380	3/18 (17%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	14/57 (25%)
		leucine-rich repeat	131..154	CDD:275380	1/22 (5%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..202	CDD:275380	7/23 (30%)
		leucine-rich repeat	203..225	CDD:275380	8/22 (36%)
		leucine-rich repeat	226..253	CDD:275380	7/26 (27%)
		LRR_8	254..337	CDD:338972	30/107 (28%)
		leucine-rich repeat	254..302	CDD:275380	20/71 (28%)
		leucine-rich repeat	303..326	CDD:275380	5/23 (22%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		PCC	332..>413	CDD:188093	17/82 (21%)
		PRK10927	<1061..>1097	CDD:236797
Lrrtm3	NP_001099857.1	LRRNT	33..61	CDD:214470	3/16 (19%)
		LRR 1	61..83		4/23 (17%)
		leucine-rich repeat	66..86	CDD:275380	7/46 (15%)
		LRR_RI	<81..300	CDD:238064	67/252 (27%)
		LRR 2	84..107		9/22 (41%)
		LRR_8	86..145	CDD:290566	20/59 (34%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		LRR 3	109..131		6/21 (29%)
		leucine-rich repeat	111..134	CDD:275380	7/23 (30%)
		LRR 4	132..155		5/23 (22%)
		LRR_8	133..193	CDD:290566	19/63 (30%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR 5	156..179		8/26 (31%)
		leucine-rich repeat	159..182	CDD:275380	7/26 (27%)
		LRR_8	181..241	CDD:290566	17/60 (28%)
		LRR 6	181..203		7/21 (33%)
		leucine-rich repeat	183..206	CDD:275380	9/22 (41%)
		LRR 7	205..227		7/22 (32%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		LRR 8	229..251		3/21 (14%)
		LRR_8	230..290	CDD:290566	13/59 (22%)
		leucine-rich repeat	231..254	CDD:275380	3/22 (14%)
		LRR 9	252..276		5/23 (22%)
		leucine-rich repeat	255..279	CDD:275380	5/23 (22%)
		LRR 10	277..300		7/25 (28%)
		leucine-rich repeat	280..300	CDD:275380	6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..411		9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910