DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and Lgr4

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_775450.2	Gene:	Lgr4 / 286994	RGDID:	628615	Length:	951	Species:	Rattus norvegicus

Alignment Length:	335	Identity:	108/335 - (32%)
Similarity:	152/335 - (45%)	Gaps:	58/335 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 LYVNNSTISELPDAVFSNLS------LHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADV 144
            |.:||  ||.:||..|:|||      |||.::.|     ::...|.|.:: |..|:|..|.|.:.
  Rat   184 LALNN--ISSIPDFAFTNLSSLVVLHLHNNKIKS-----LSQHCFDGLDN-LETLDLNYNNLDEF 240

  Fly   145 PVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASN-AFRGLEQ------- 201
            | :|:|.|..|..|....|.:|.|||.||.|...|.|:.|.||.::...| ||..|..
  Rat   241 P-QAIKALPSLKELGFHSNSISVIPDGAFGGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIR 304

  Fly   202 ---------------SLKNLNLKGTKQRKVPESI-RGLKSLAFLDLSQNGIKELPGAGGIRVFDG 250
                           .|::|.|.|||...:|:.: :..|.|..||||.|.|::||.      |:|
  Rat   305 GASLVQWFPNLTGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLSYNNIRDLPS------FNG 363

  Fly   251 LDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTS 315
            ..||..::|:||.|..|.|..|.|: .:|..|.|..||:.|...||...|..:..||:.||.|||
  Rat   364 CRALEEISLQRNQISLIKENTFQGL-TSLRILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTS 427

  Fly   316 LPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDL 380
            .|.   .|..|:..|.|.||  ..:.:...|...|.||.||:...:..|       |.|..:...
  Rat   428 FPT---EGLNGLNQLKLVGN--FKLKDALAARDFANLRSLSVPYAYQCC-------AFWGCDSYA 480

  Fly   381 QVTSRERNPQ 390
            .:.:.:.:||
  Rat   481 NLNTEDNSPQ 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	64/195 (33%)
		leucine-rich repeat	86..105	CDD:275380	9/18 (50%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	24/57 (42%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	9/45 (20%)
		leucine-rich repeat	203..225	CDD:275380	7/22 (32%)
		leucine-rich repeat	226..253	CDD:275380	11/26 (42%)
		LRR_8	254..337	CDD:338972	32/82 (39%)
		leucine-rich repeat	254..302	CDD:275380	18/47 (38%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		PCC	332..>413	CDD:188093	14/59 (24%)
		PRK10927	<1061..>1097	CDD:236797
Lgr4	NP_775450.2	LRRNT	29..61	CDD:214470
		LRR 1	58..79
		leucine-rich repeat	59..82	CDD:275380
		LRR	<62..301	CDD:227223	45/125 (36%)
		LRR 2	82..103
		leucine-rich repeat	83..106	CDD:275380
		LRR 3	106..127
		leucine-rich repeat	107..130	CDD:275380
		LRR 4	130..151
		leucine-rich repeat	131..154	CDD:275380
		LRR 5	154..177
		leucine-rich repeat	155..178	CDD:275380
		LRR 6	178..199		8/16 (50%)
		leucine-rich repeat	179..202	CDD:275380	10/19 (53%)
		LRR 7	202..223		5/25 (20%)
		leucine-rich repeat	203..226	CDD:275380	6/27 (22%)
		LRR 8	226..247		8/22 (36%)
		leucine-rich repeat	227..249	CDD:275380	9/22 (41%)
		LRR 9	249..270		9/20 (45%)
		leucine-rich repeat	250..273	CDD:275380	10/22 (45%)
		LRR 10	273..294		8/20 (40%)
		leucine-rich repeat	274..295	CDD:275380	8/20 (40%)
		LRR	275..>465	CDD:227223	66/201 (33%)
		LRR 11	320..341		7/20 (35%)
		leucine-rich repeat	321..344	CDD:275378	7/22 (32%)
		LRR 12	344..365		11/26 (42%)
		LRR_8	345..401	CDD:404697	25/62 (40%)
		leucine-rich repeat	345..366	CDD:275378	11/26 (42%)
		LRR 13	366..387		9/20 (45%)
		leucine-rich repeat	367..390	CDD:275378	9/23 (39%)
		LRR 14	390..411		8/20 (40%)
		leucine-rich repeat	391..414	CDD:275378	9/22 (41%)
		LRR 15	414..435		9/23 (39%)
		leucine-rich repeat	415..427	CDD:275378	5/11 (45%)
		leucine-rich repeat	436..461	CDD:275380	7/26 (27%)
		7tmA_LGR4	539..812	CDD:320483
		TM helix 1	541..565	CDD:320483
		TM helix 2	574..595	CDD:320483
		TM helix 3	619..641	CDD:320483
		TM helix 4	664..680	CDD:320483
		TM helix 5	704..727	CDD:320483
		TM helix 6	746..768	CDD:320483
		TM helix 7	780..805	CDD:320483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910