DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment haf and Vasn

DIOPT Version :9

Sequence 1:NP_001356954.1 Gene:haf / 33339 FlyBaseID:FBgn0261509 Length:1347 Species:Drosophila melanogaster
Sequence 2:NP_647468.2 Gene:Vasn / 246154 MGIID:2177651 Length:673 Species:Mus musculus


Alignment Length:808 Identity:192/808 - (23%)
Similarity:284/808 - (35%) Gaps:229/808 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TALPAATTPLLLLLPLILGRLHVAHAQ-CPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLL 71
            :.||    ||||||.::||    :..| ||         :.|            ||:|.......
Mouse     5 SCLP----PLLLLLLVLLG----SGVQGCP---------SGC------------QCNQPQTVFCT 40

  Fly    72 AAMNTHA-RLKPVDL--LYVNNSTISELPDAVFSNL-SLHNLQLSSCGIQRIATGAFKGQESVLR 132
            |...|.. |..|.|.  ||:..:.|:.|....|:.| .|..|.||...|..:..|.|:...: |.
Mouse    41 ARQGTTVPRDVPPDTVGLYIFENGITTLDVGCFAGLPGLQLLDLSQNQITSLPGGIFQPLVN-LS 104

  Fly   133 NLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNN--------- 188
            ||:|..|.|.::..|..:.|.:|..|.|.||::.||...||..|.:|..|||.||.         
Mouse   105 NLDLTANKLHEISNETFRGLRRLERLYLGKNRIRHIQPGAFDALDRLLELKLPDNELRVLPPLHL 169

  Fly   189 -----VTLASNAFRGLE------QSLKNLNLKGTKQRKVPESIRG-LKSLAFLDLSQNGIKELPG 241
                 :.|:.|:...||      .:::.|.|.|...|::.|.:.| |.:|..||:|.|.::.:|.
Mouse   170 PRLLLLDLSHNSIPALEAGILDTANVEALRLAGLGLRQLDEGLFGRLLNLHDLDVSDNQLEHMPS 234

  Fly   242 AGGIRVFDGLDALTALNLERNLIQSIGETAFAGVR-KTLSSLSLLNNLLAEFPIGAVHSLKELRV 305
                 |..||..||.|.|       .|.|..|.:| :.|:.|:               :|:||.|
Mouse   235 -----VIQGLRGLTRLRL-------AGNTRIAQIRPEDLAGLT---------------ALQELDV 272

  Fly   306 LDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRW 370
            .::....|.|...:.|   |.:.|||...||                         .:|.|.|.|
Mouse   273 SNLSLQALPSDLSSLF---PRLRLLAAARNP-------------------------FNCLCPLSW 309

  Fly   371 VAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTL 435
            ...|:|...:.:.|.|...  |..||:...|....:...:..||                     
Mouse   310 FGPWVRENHVVLASPEETR--CHFPPKNAGRLLLDLDYADFGCP--------------------- 351

  Fly   436 PSSPDSVEYETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRST---TRPP 497
                             |.|.||....:.|::...|.:|:....|..:..||||:.||   |.||
Mouse   352 -----------------VTTTTATVPTIRSTIREPTLSTSSQAPTWPSLTEPTTQASTVLSTAPP 399

  Fly   498 TKSTTTISATTASPASNPPVNGTGTVQATSITTSSSSSSSSSTSTGHGNGKQAPGW-----RQGV 557
                      |..||..|        |....:...:..|....:..|.......|:     ...|
Mouse   400 ----------TMRPAPQP--------QDCPASICLNGGSCRLGARHHWECLCPEGFIGLYCESPV 446

  Fly   558 TNGNGNSGVGGAGGLHKPQRPPLV-LGYPPQRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANI 621
            ..|...|.:...     |:.|||: |...|...|.:    .|:::...:          .:|..:
Mouse   447 EQGMKPSSIPDT-----PRPPPLLPLSIEPVSPTSL----RVKLQRYLQ----------GNTVQL 492

  Fly   622 LGFRVVYRLFGEKAFKQGPP-------LESSEREFKIKNVPAQECIIVCVISLEELHVTPETVPY 679
            ...|:.||..      .||.       |.:|..|:.:..:.......:||..|.... |||  ..
Mouse   493 RSLRLTYRNL------SGPDKRLVTLRLPASLAEYTVTQLRPNATYSICVTPLGAGR-TPE--GE 548

  Fly   680 QQCREVRTVASQASNMDKITIAAS-------AAICGTIIVAVIVFIAAS---RRSRKLQSSQQKS 734
            :.|.|..|..:..||...:|.|..       |.....:::||:....|:   ||:|...::|.|.
Mouse   549 EACGEANTSQAVRSNHAPVTQAREGNLPLLIAPALAAVLLAVLAAAGAAYCVRRARATSTAQDKG 613

  Fly   735 PLPIGGLPVNCCGPTGSPGPL--GSIAT 760
            .:..|..|:..   .|...||  ||.||
Mouse   614 QVGPGTGPLEL---EGVKAPLEPGSKAT 638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hafNP_001356954.1 LRR <52..>252 CDD:227223 64/224 (29%)
leucine-rich repeat 86..105 CDD:275380 6/19 (32%)
leucine-rich repeat 106..129 CDD:275380 7/22 (32%)
LRR_8 131..189 CDD:338972 24/71 (34%)
leucine-rich repeat 131..154 CDD:275380 8/22 (36%)
leucine-rich repeat 155..178 CDD:275380 10/22 (45%)
leucine-rich repeat 179..202 CDD:275380 10/42 (24%)
leucine-rich repeat 203..225 CDD:275380 7/22 (32%)
leucine-rich repeat 226..253 CDD:275380 9/26 (35%)
LRR_8 254..337 CDD:338972 22/83 (27%)
leucine-rich repeat 254..302 CDD:275380 11/48 (23%)
leucine-rich repeat 303..326 CDD:275380 5/22 (23%)
leucine-rich repeat 327..350 CDD:275380 5/22 (23%)
PCC 332..>413 CDD:188093 14/80 (18%)
PRK10927 <1061..>1097 CDD:236797
VasnNP_647468.2 LRRNT 24..55 CDD:214470 10/51 (20%)
leucine-rich repeat 35..57 CDD:275380 5/21 (24%)
LRR 1 54..75 6/20 (30%)
LRR_8 58..113 CDD:290566 18/55 (33%)
leucine-rich repeat 58..78 CDD:275380 6/19 (32%)
LRR_RI <76..273 CDD:238064 65/224 (29%)
LRR_4 77..118 CDD:289563 13/41 (32%)
LRR 2 78..99 7/20 (35%)
leucine-rich repeat 79..102 CDD:275380 7/22 (32%)
LRR_8 102..161 CDD:290566 24/59 (41%)
LRR 3 102..123 7/21 (33%)
leucine-rich repeat 103..126 CDD:275380 8/22 (36%)
LRR 4 126..147 9/20 (45%)
leucine-rich repeat 127..150 CDD:275380 10/22 (45%)
LRR 5 150..170 6/19 (32%)
leucine-rich repeat 151..194 CDD:275380 10/42 (24%)
LRR 6 171..192 4/20 (20%)
LRR_8 194..250 CDD:290566 20/67 (30%)
LRR 7 194..215 5/20 (25%)
leucine-rich repeat 195..218 CDD:275380 7/22 (32%)
LRR 8 218..239 7/25 (28%)
leucine-rich repeat 219..241 CDD:275380 9/26 (35%)
LRR_8 240..301 CDD:290566 23/110 (21%)
LRR 9 241..265 9/30 (30%)
leucine-rich repeat 242..266 CDD:275380 10/45 (22%)
LRR 10 266..288 6/21 (29%)
LRRCT 299..350 CDD:214507 14/77 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..389 6/19 (32%)
EGF 410..441 CDD:278437 3/30 (10%)
fn3 468..537 CDD:278470 13/88 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 608..648 11/34 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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