DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and Lrrc4c

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001276671.1	Gene:	Lrrc4c / 241568	MGIID:	2442636	Length:	640	Species:	Mus musculus

Alignment Length:	604	Identity:	151/604 - (25%)
Similarity:	239/604 - (39%)	Gaps:	133/604 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PLLLLLPLILGRLHVA---HAQ-CPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNT 76
            |||::| |.|..|.||   .|| ||         :.|.|:....:.:.|:
Mouse    25 PLLVVL-LALQLLVVAGLVRAQTCP---------SVCSCSNQFSKVICVR--------------- 64

  Fly    77 HARLKPVDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLL 141
                          ..:.|:||.:.:|..|.||..:.  ||.|...:||.... |..|.|..|.:
Mouse    65 --------------KNLREVPDGISTNTRLLNLHENQ--IQIIKVNSFKHLRH-LEILQLSRNHI 112

  Fly   142 ADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNV-TLASNAFRGLEQSLKN 205
            ..:.:.|...|..||.|:|..|:|:.||:.|||.|:||..|.|.:|.: ::.|.||..: .||:.
Mouse   113 RTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRI-PSLRR 176

  Fly   206 LNLKGTKQRK-VPE-SIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIG 268
            |:|...|:.. :.| :..||.:|.:|:|:...::|:|....:...|.||      |..|.:.:|.
Mouse   177 LDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELD------LSGNHLSAIR 235

  Fly   269 ETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALD 333
            ..:|.|:.. |..|.::.:.:......|..:|:.|..:::..|.||.||...|.....:..:.|.
Mouse   236 PGSFQGLMH-LQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLH 299

  Fly   334 GNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRF 398
            .||                         .:|:|.:.|::.|||:   ...|.......|.|||..
Mouse   300 HNP-------------------------WNCNCDILWLSWWIRD---MAPSNTACCARCNTPPNL 336

  Fly   399 RDRGFYSIQPEELSC--PDIAD--AALRGPVGLADNLKPTLPSSPDSVEYETGTGT--------- 450
            :.|....:.....:|  |.|.:  |.|....|:|..||....:|..||.:.|..||
Mouse   337 KGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKV 401

  Fly   451 -------GTVG--------TGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKS 500
                   ||:.        || ..:..|::||.::|::.|...|..|||  |.:..||....|..
Mouse   402 RIAVLSDGTLNFTNVTVQDTG-MYTCMVSNSVGNTTASATLNVTAATTT--PFSYFSTVTVETME 463

  Fly   501 TTTISATTASPASNP-PVNGTGTVQATSITTSSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNS 564
            .:...|.|......| ||....|...|:..|..|:.|:..|.|              :...:.||
Mouse   464 PSQDEARTTDNNVGPTPVIDWETTNVTTSLTPQSTRSTEKTFT--------------IPVTDINS 514

  Fly   565 GVGGAGGLHKPQRPPLVLG 583
            |:.|...:.|..:  :::|
Mouse   515 GIPGIDEVMKTTK--IIIG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	53/202 (26%)
		leucine-rich repeat	86..105	CDD:275380	4/18 (22%)
		leucine-rich repeat	106..129	CDD:275380	8/22 (36%)
		LRR_8	131..189	CDD:338972	23/57 (40%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	12/22 (55%)
		leucine-rich repeat	179..202	CDD:275380	7/23 (30%)
		leucine-rich repeat	203..225	CDD:275380	7/23 (30%)
		leucine-rich repeat	226..253	CDD:275380	7/26 (27%)
		LRR_8	254..337	CDD:338972	18/82 (22%)
		leucine-rich repeat	254..302	CDD:275380	9/47 (19%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	3/22 (14%)
		PCC	332..>413	CDD:188093	15/80 (19%)
		PRK10927	<1061..>1097	CDD:236797
Lrrc4c	NP_001276671.1	LRRNT	47..80	CDD:214470	9/70 (13%)
		PPP1R42	65..235	CDD:411060	56/179 (31%)
		LRR 1	77..98		8/22 (36%)
		leucine-rich repeat	78..101	CDD:275380	8/24 (33%)
		LRR 2	101..122		5/21 (24%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		LRR 3	125..146		10/20 (50%)
		leucine-rich repeat	126..149	CDD:275380	12/22 (55%)
		LRR 4	149..170		8/20 (40%)
		leucine-rich repeat	150..173	CDD:275380	7/23 (30%)
		LRR 5	173..195		6/21 (29%)
		leucine-rich repeat	174..198	CDD:275380	7/23 (30%)
		LRR 6	198..219		5/20 (25%)
		leucine-rich repeat	199..220	CDD:275380	5/20 (25%)
		LRR_8	220..279	CDD:404697	14/65 (22%)
		LRR 7	220..241		7/26 (27%)
		leucine-rich repeat	221..244	CDD:275380	8/28 (29%)
		LRR 8	244..265		3/21 (14%)
		leucine-rich repeat	245..268	CDD:275380	4/22 (18%)
		LRR_8	267..>301	CDD:404697	8/33 (24%)
		LRR 9	268..289		7/20 (35%)
		leucine-rich repeat	269..290	CDD:275380	7/20 (35%)
		LRRCT	301..>339	CDD:214507	13/65 (20%)
		IG	360..443	CDD:214652	21/83 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..482		4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910