DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and slt-1

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_510437.2	Gene:	slt-1 / 181562	WormBaseID:	WBGene00004854	Length:	1410	Species:	Caenorhabditis elegans

Alignment Length:	490	Identity:	121/490 - (24%)
Similarity:	190/490 - (38%)	Gaps:	126/490 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLLLPLILGRLHVAHAQCPWQRDVPDLQTSCI------CAYNLGRE---LSVQCDQV------DF 67
            :||:|        ..|.||.:....|...||:      ...|:..:   |.:|.:::      ||
Worm     8 ILLIP--------ESATCPAECVCVDRTVSCVGQQLTEVPQNIPNDTIRLDLQDNEITKIGPNDF 64

  Fly    68 SQLLAAMNTHA-RLKPVDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVL 131
            |.|   ||..| :|....::.::|.:.|.|   ||    |..|:||...|:.:....|:.... |
Worm    65 SSL---MNLKALQLMDNQIVTIHNQSFSSL---VF----LQKLRLSRNRIRHLPDNVFQNNLK-L 118

  Fly   132 RNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTL---AS 193
            .:|:|.:|.:..|....|:....|.:|:|.||.:..:.::.......|..|.||.|.:|.   .|
Worm   119 THLDLSENDITVVSDAQLQGPEFLEVLNLDKNHIFCLENNVISSWVSLEVLTLNGNRLTTFEEPS 183

  Fly   194 NA-FRGLEQSLKN------------------------------LNLKGT---------------- 211
            || ||.|:  |.|                              |||:|:
Worm   184 NARFRQLD--LFNNPWNCDCRLRWMRKWLEKAEGQNKTVCATPLNLQGSSIEILQDKFMTCSGNR 246

  Fly   212 --KQRKVPESIR------------------GL--------KSLAFLDLSQNGIKELPGAGGIRVF 248
              :.:|..|:..                  ||        .|...:.|.||.|..:|.    ..|
Worm   247 KRRYKKTCETAEICPLPCTCTGTTVDCRDSGLTYVPTNLPPSTTEIRLEQNQISSIPS----HSF 307

  Fly   249 DGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLL 313
            ..|..||.|:|.:|:|..|...||.|:. .|.:|.|..|.:.:........|..|::|.:..|.|
Worm   308 KNLKNLTRLDLSKNIITEIQPKAFLGLH-NLHTLVLYGNNITDLKSDTFEGLGSLQLLLLNANQL 371

  Fly   314 TSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNG 378
            |.:....|...|.:::|:|..|.:.|:.|..|.:| .:|..|.|....|.|||.|:|:|:.....
Worm   372 TCIRRGTFDHVPKLSMLSLYDNDIKSISEVTFQNL-TSLSTLHLAKNPLICDCNLQWLAQINLQK 435

  Fly   379 DLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSC 413
            ::: ||..|    |..|.|.|.:.|.::.|.:..|
Worm   436 NIE-TSGAR----CEQPKRLRKKKFATLPPNKFKC 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	62/287 (22%)
		leucine-rich repeat	86..105	CDD:275380	5/18 (28%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	16/57 (28%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	5/22 (23%)
		leucine-rich repeat	179..202	CDD:275380	12/26 (46%)
		leucine-rich repeat	203..225	CDD:275380	10/95 (11%)
		leucine-rich repeat	226..253	CDD:275380	7/26 (27%)
		LRR_8	254..337	CDD:338972	25/82 (30%)
		leucine-rich repeat	254..302	CDD:275380	15/47 (32%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	25/80 (31%)
		PRK10927	<1061..>1097	CDD:236797
slt-1	NP_510437.2	LRRNT	17..47	CDD:214470	6/29 (21%)
		leucine-rich repeat	26..45	CDD:275380	3/18 (17%)
		LRR_RI	<48..195	CDD:238064	45/159 (28%)
		LRR_8	48..104	CDD:290566	19/65 (29%)
		leucine-rich repeat	48..69	CDD:275380	6/23 (26%)
		leucine-rich repeat	70..93	CDD:275380	5/25 (20%)
		LRR_8	94..152	CDD:290566	17/58 (29%)
		leucine-rich repeat	94..117	CDD:275380	6/22 (27%)
		leucine-rich repeat	118..165	CDD:275380	11/46 (24%)
		LRR_8	142..196	CDD:290566	19/55 (35%)
		leucine-rich repeat	142..163	CDD:275380	5/20 (25%)
		leucine-rich repeat	166..284	CDD:275380	22/119 (18%)
		LRRCT	195..243	CDD:214507	4/47 (9%)
		LRRNT	259..291	CDD:214470	3/31 (10%)
		leucine-rich repeat	285..312	CDD:275380	8/30 (27%)
		LRR_8	287..347	CDD:290566	22/64 (34%)
		LRR_4	311..352	CDD:289563	14/41 (34%)
		leucine-rich repeat	313..336	CDD:275380	10/23 (43%)
		LRR_8	336..419	CDD:290566	22/83 (27%)
		leucine-rich repeat	337..384	CDD:275380	11/46 (24%)
		leucine-rich repeat	385..408	CDD:275380	7/23 (30%)
		LRRCT	417..466	CDD:214507	17/54 (31%)
		LRRNT	484..512	CDD:214470
		leucine-rich repeat	494..516	CDD:275380
		LRR_RI	<514..635	CDD:238064
		leucine-rich repeat	517..538	CDD:275380
		LRR_8	538..597	CDD:290566
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..586	CDD:275380
		leucine-rich repeat	587..610	CDD:275380
		leucine-rich repeat	611..675	CDD:275380
		leucine-rich repeat	676..729	CDD:275380
		LRRNT	677..708	CDD:214470
		LRR_8	729..788	CDD:290566
		LRR_4	729..771	CDD:289563
		leucine-rich repeat	730..753	CDD:275380
		leucine-rich repeat	754..777	CDD:275380
		leucine-rich repeat	778..799	CDD:275380
		EGF_CA	909..945	CDD:238011
		EGF_CA	947..983	CDD:238011
		EGF_CA	<994..1023	CDD:238011
		EGF_CA	1025..1061	CDD:238011
		LamG	1133..1268	CDD:214598
		CT	1334..1405	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910