DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and Igfals

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001351825.1	Gene:	Igfals / 16005	MGIID:	107973	Length:	638	Species:	Mus musculus

Alignment Length:	584	Identity:	140/584 - (23%)
Similarity:	217/584 - (37%)	Gaps:	161/584 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TTTALPAATTPLLLLLPLILGRLHVAHAQCPWQ---------RDVPDLQTSCICAY-NLGRELSV 60
            |..:.|...:|.|    ::|....||...|..|         .:.|....:|.|:| :...||||
Mouse    33 TEPSAPYRGSPAL----VVLLAFWVALGPCYLQGTDPGASADAEGPQCPVTCTCSYDDYTDELSV 93

  Fly    61 QCDQVDFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNLS-------------------- 105
            .|...:.:||..::....|     .|:::.:.:|.:|.|.|.|||
Mouse    94 FCSSRNLTQLPDSIPVSTR-----ALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQAL 153

  Fly   106 -----LHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQL 165
                 |::|.|....::.:|.|.|:...| |.:|:|.:|||..:.....:.|..|..|:|..|.|
Mouse   154 LGLQNLYHLHLERNLLRSLAAGLFRHTPS-LASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSL 217

  Fly   166 SHIPDDAFVGLTKLSTLKLNDNNVT-----------------LASNAFRGLEQS-------LKNL 206
            ..:||..|.||..|..|.|..|.:|                 |:.||.|.::.:       |:.|
Mouse   218 VVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKL 282

  Fly   207 NL-KGTKQRKVPESIRGLKSLAFLDLSQNGIKEL-----PGAGGI---------------RVFDG 250
            .| :.......|.:..|:|:|.:||||.|.:..|     ||..|:               |.|..
Mouse   283 YLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHNAITSLRPRTFKD 347

  Fly   251 LDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTS 315
            |..|..|.|..|.|:.:||..|.|:.: |..|:|.:|.:.|..:||...|..:.|:::..|.|.|
Mouse   348 LHFLEELQLGHNRIRQLGEKTFEGLGQ-LEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGNCLRS 411

  Fly   316 LPEAAFR------------------------GNPGITLLALDGNPLSSVPEGAFAHLNATL---- 352
            |||..|:                        |..|:..|.|..|.:||:.|.:.|.|:..|
Mouse   412 LPEHVFQGLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDL 476

  Fly   353 -------------RGLSLGGRFLHCDCKLRWVAE----------WI---RN-------------G 378
                         :||......|..:.:|..::|          |:   .|             |
Mouse   477 TANQLTHLPRQLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLG 541

  Fly   379 DLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCP--DIADAALRGPVGLADNLKPTLPSSPD 440
            .|:..:...|......|....:|.:....|.:.|||  .:.|.||:.| |:......|:....|
Mouse   542 RLRYLNLRNNSLQTFVPQPGLERLWLDANPWDCSCPLKALRDFALQNP-GVVPRFVQTVCEGDD 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	68/270 (25%)
		leucine-rich repeat	86..105	CDD:275380	6/18 (33%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	21/57 (37%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	9/39 (23%)
		leucine-rich repeat	203..225	CDD:275380	5/22 (23%)
		leucine-rich repeat	226..253	CDD:275380	13/46 (28%)
		LRR_8	254..337	CDD:338972	30/106 (28%)
		leucine-rich repeat	254..302	CDD:275380	17/47 (36%)
		leucine-rich repeat	303..326	CDD:275380	9/46 (20%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		PCC	332..>413	CDD:188093	21/123 (17%)
		PRK10927	<1061..>1097	CDD:236797
Igfals	NP_001351825.1	LRRNT	75..113	CDD:214470	11/42 (26%)
		leucine-rich repeat	92..110	CDD:275380	5/17 (29%)
		PLN00113	96..>558	CDD:331614	109/468 (23%)
		leucine-rich repeat	114..134	CDD:275380	7/19 (37%)
		leucine-rich repeat	135..158	CDD:275380	0/22 (0%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		leucine-rich repeat	183..206	CDD:275380	7/22 (32%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		leucine-rich repeat	255..278	CDD:275380	4/22 (18%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	3/22 (14%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..396	CDD:275380	7/20 (35%)
		leucine-rich repeat	423..446	CDD:275380	1/22 (5%)
		leucine-rich repeat	447..470	CDD:275380	8/22 (36%)
		leucine-rich repeat	471..494	CDD:275380	3/22 (14%)
		leucine-rich repeat	495..516	CDD:275380	3/20 (15%)
		leucine-rich repeat	519..542	CDD:275380	2/22 (9%)
		leucine-rich repeat	543..561	CDD:275380	3/17 (18%)
		TPKR_C2	570..613	CDD:326558	11/36 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910