DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and AgaP_AGAP011378

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_317944.4	Gene:	AgaP_AGAP011378 / 1278321	VectorBaseID:	AGAP011378	Length:	368	Species:	Anopheles gambiae

Alignment Length:	377	Identity:	110/377 - (29%)
Similarity:	169/377 - (44%)	Gaps:	68/377 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 AAMNTHARLKPVDLLYVNNSTISELPDAVFS-NLSLHNLQLSSCGIQRIATGAFKGQESVLRNLN 135
            ::|..:|.|..:||.|   :.:..:|...|: ...|..|.|:...:..|....|.|..: |..||
Mosquito    22 SSMQFYAELTFLDLSY---NHLFNMPPRTFAYQRKLTELHLNHNKVGSITNKTFVGLVA-LTVLN 82

  Fly   136 LQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT---------- 190
            |:.|.|.::|......:.||..|:|.:|:::.|...||.|||.|..|.|:||.::
Mosquito    83 LRGNFLDELPEGVFAGVPKLEELNLGQNRIAKIDPKAFAGLTGLRVLYLDDNTISAVPSPALQPL 147

  Fly   191 -------LASNAFRGLEQ-------SLKNLNLKGTKQRKVP-ESIRGLKSLAFLDLSQNGIKELP 240
                   :..|:|..:.:       .|..|:|:|.....|. :|.|||:.|..||||.|.:..:|
Mosquito   148 RALGELYIGLNSFAAIPKEAFAMLTGLAKLDLEGAALLNVSRDSFRGLERLRTLDLSDNRLARIP 212

  Fly   241 GAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRV 305
            .| .:.|   |:.|..|:|.:|..::|...||||          |||               |||
Mosquito   213 TA-ELAV---LERLEELSLGQNDFEAIPPNAFAG----------LNN---------------LRV 248

  Fly   306 LDIGFNL-LTSLPEAAFRGNPGITLLALDGNP-LSSVPEGAFAHLNATLRGLSLGGRFLHCDCKL 368
            |||..:| ||.:...||..|..:..:.:..|. |:.|.:||.:.| ..||.|.|....:.|||::
Mosquito   249 LDISGSLKLTRIESGAFAHNTNLEEIVIASNKMLTEVQDGALSGL-PHLRRLDLSENLILCDCQI 312

  Fly   369 RWVAEWI---RNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSC--PD 415
            .|:...:   .||.:...: ::.|..|.:|.|.|.:...|:.||.|.|  ||
Mosquito   313 LWLRNLLVSRSNGTVGAAA-QQIPVVCASPDRLRGQVLQSLSPELLGCTHPD 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	57/205 (28%)
		leucine-rich repeat	86..105	CDD:275380	3/19 (16%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	23/57 (40%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..202	CDD:275380	7/46 (15%)
		leucine-rich repeat	203..225	CDD:275380	9/22 (41%)
		leucine-rich repeat	226..253	CDD:275380	10/26 (38%)
		LRR_8	254..337	CDD:338972	25/84 (30%)
		leucine-rich repeat	254..302	CDD:275380	12/47 (26%)
		leucine-rich repeat	303..326	CDD:275380	12/23 (52%)
		leucine-rich repeat	327..350	CDD:275380	6/23 (26%)
		PCC	332..>413	CDD:188093	25/84 (30%)
		PRK10927	<1061..>1097	CDD:236797
AgaP_AGAP011378	XP_317944.4	leucine-rich repeat	7..29	CDD:275380	1/6 (17%)
		LRR_8	29..86	CDD:290566	16/60 (27%)
		leucine-rich repeat	30..53	CDD:275380	6/25 (24%)
		leucine-rich repeat	54..77	CDD:275380	6/22 (27%)
		LRR_RI	78..309	CDD:238064	78/260 (30%)
		LRR_8	78..134	CDD:290566	21/55 (38%)
		leucine-rich repeat	78..101	CDD:275380	7/22 (32%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		leucine-rich repeat	126..149	CDD:275380	5/22 (23%)
		LRR_8	148..208	CDD:290566	17/59 (29%)
		leucine-rich repeat	150..173	CDD:275380	2/22 (9%)
		leucine-rich repeat	174..197	CDD:275380	9/22 (41%)
		leucine-rich repeat	198..221	CDD:275380	10/26 (38%)
		leucine-rich repeat	222..245	CDD:275380	10/32 (31%)
		LRR_8	245..306	CDD:290566	23/76 (30%)
		leucine-rich repeat	246..267	CDD:275380	11/20 (55%)
		leucine-rich repeat	271..293	CDD:275380	5/21 (24%)
		LRRCT	308..360	CDD:214507	15/52 (29%)
		leucine-rich repeat	315..340	CDD:275381	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910