DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and AgaP_AGAP000054

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_311104.5	Gene:	AgaP_AGAP000054 / 1272222	VectorBaseID:	AGAP000054	Length:	1593	Species:	Anopheles gambiae

Alignment Length:	1065	Identity:	224/1065 - (21%)
Similarity:	343/1065 - (32%)	Gaps:	396/1065 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLKPVDLLY 87
            |:|...|:        ||:|   ......|.| |:|.:..:  |..::.:.:.....|..:|
Mosquito    42 LLLDANHI--------RDLP---KGFFRLYRL-RKLGLSDN--DIIKIPSDIQNFVNLVELD--- 89

  Fly    88 VNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRN---LNLQDNLLADVPVEAL 149
            |:.:.|.::|:.:....||.....||..|.|:..|.     :.|||   |.|.|..|..:| :..
Mosquito    90 VSRNEIGDIPEDIKHLRSLQIADFSSNPISRLPAGF-----TQLRNLTVLGLNDMSLISLP-QDF 148

  Fly   150 KVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNV-TLASNAFRGLEQSLKNLNLKGTKQ 213
            ..|.||..|:|.:|.|.::| ::...||||..|.|.||.: .|.|:.  |...||:.|.|...:.
Mosquito   149 GCLSKLVSLELRENLLKNLP-ESISQLTKLERLDLGDNEIDELPSHV--GYLPSLQELWLDHNQL 210

  Fly   214 RKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKT 278
            .::|..|..||.|..||:|:|.::|||...|     ||:.||.|:|.:||:    ||...|:.|
Mosquito   211 LRLPPEIGLLKKLVCLDVSENRLEELPEEIG-----GLECLTDLHLSQNLL----ETLPNGISK- 265

  Fly   279 LSSLSLL--------------------------NNLLAEFP--IG----------------AVHS 299
            |::||:|                          .|.|:|.|  :|                ||.|
Mosquito   266 LTNLSILKLDQNRLHTLNDSIGCCVHMQELILTENFLSELPATVGNMLVLNNLNVDRNSLVAVPS 330

  Fly   300 ----LKELRVLDIGFNLLTSLPEAAFRGNPG-ITLLALDGNPLSSVPEGAFAHLNATLRGLSLGG 359
                .::|.||.:..|.||.||  |..||.| :.:|.:.||.|..:|   ::.:|..|:.:
Mosquito   331 ELGNCRQLGVLSLRENKLTRLP--AELGNCGELHVLDVSGNLLQHLP---YSLVNLQLKAV---- 386

  Fly   360 RFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGP 424
                      |::|           .:..|     .|.|:              ||: |......
Mosquito   387 ----------WLSE-----------NQSQP-----VPTFQ--------------PDV-DETTNEQ 410

  Fly   425 VGLADNLKPT---LPSSP------DSVEYETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTT 480
            | |...|.|.   :||:|      ||..:|....:.|      .|...|....:...|
Mosquito   411 V-LTCFLLPQQRYVPSNPSQREDTDSENWEEREASRT------HSVKFTEDFGADRDT------- 461

  Fly   481 TTTTAEPTTRRSTTRPP-------------------TKSTTTISATTASPASNPPVNGTGTVQAT 526
                  |..|::|..|.                   :.:..|:|..:||..|....:|.||....
Mosquito   462 ------PFVRQNTPHPKELKMKAHKLFAKERKSDDLSGNLDTLSEESASRPSLLNRSGYGTATME 520

  Fly   527 SITTSSSSSSSSSTSTGHG------NGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYP 585
            .|             .||.      .|:.|.|      :.....||.||
Mosquito   521 DI-------------QGHAIPHDEEQGEAAAG------SAEAGGGVEGA---------------- 550

  Fly   586 PQRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQG--PPLESSERE 648
                ...:|..|.:|.....:|.      |.|...        :.:||...:.|  .|:....|.
Mosquito   551 ----QDDEDGYEKRVGFEVNEDE------DDDPER--------QQYGEDGDEHGGKKPISKLHRR 597

  Fly   649 ---FKIKNVPAQECIIVCVISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASAAICGTI 710
               ..:||              :.:|              .|:..:.:|:
Mosquito   598 DTPHHLKN--------------KRVH--------------HTITDKNTNL--------------- 619

  Fly   711 IVAVIVFIAASRRSRKLQSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHKEWDQVSA 775
                           ...|.:.|...|                                 .::..
Mosquito   620 ---------------MFNSLKLKEMTP---------------------------------PKLDE 636

  Fly   776 YSGRSIPRPRIYPVEQPDDMRSHFSGMPGKVGKSRSLADGQSQHSFSNNSHR--GYLGSAFPSNL 838
            :.....|.|.::.|:  ..::....|.||:.|..|.|    |:.|...:|.|  |..||..|:::
Mosquito   637 HPAMEPPVPPMFSVK--FKVKDGGKGGPGRKGPGRPL----SRRSSGASSFRSSGTSGSLPPASI 695

  Fly   839 VNSRPELRQSRQSLAAASERMSRASYAGSIHGGNGGGGGLGGNGGGGGNGLPVSSLMAMSGMVGG 903
            ::       |.:......:...|.....::..|..|..|.||.||||...|..||    |.|.|
Mosquito   696 LS-------SGKKKGGRKDDKRRIRIITAVKDGRTGPAGKGGGGGGGTFALSSSS----SPMFG- 748

  Fly   904 GGPASIASSARRSRPRSRSREQLNT----------THIHNHRPGSRYSQAGSTHTLNNYCDTSDN 958
                          .|....:.|:|          .||.....|...|.||..        .|..
Mosquito   749 --------------KRKVYDDTLDTYTALKEERLEIHIERTSAGLGLSIAGGR--------GSTP 791

  Fly   959 WTDHDMDIYMARNPTTRNGLVPLXG 983
            :...|..|:::|  .|..|...| |
Mosquito   792 FKGDDEGIFISR--VTERGPADLAG 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	62/203 (31%)
		leucine-rich repeat	86..105	CDD:275380	3/18 (17%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	24/60 (40%)
		leucine-rich repeat	131..154	CDD:275380	9/25 (36%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	8/23 (35%)
		leucine-rich repeat	203..225	CDD:275380	6/21 (29%)
		leucine-rich repeat	226..253	CDD:275380	11/26 (42%)
		LRR_8	254..337	CDD:338972	37/131 (28%)
		leucine-rich repeat	254..302	CDD:275380	22/95 (23%)
		leucine-rich repeat	303..326	CDD:275380	11/22 (50%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		PCC	332..>413	CDD:188093	11/80 (14%)
		PRK10927	<1061..>1097	CDD:236797
AgaP_AGAP000054	XP_311104.5	leucine-rich repeat	16..38	CDD:275380
		LRR_RI	23..259	CDD:238064	76/251 (30%)
		LRR_8	38..95	CDD:290566	14/69 (20%)
		leucine-rich repeat	39..58	CDD:275380	6/26 (23%)
		leucine-rich repeat	62..84	CDD:275380	4/24 (17%)
		LRR_8	84..138	CDD:290566	17/61 (28%)
		leucine-rich repeat	85..107	CDD:275380	5/24 (21%)
		leucine-rich repeat	108..130	CDD:275380	7/26 (27%)
		leucine-rich repeat	131..176	CDD:275380	14/46 (30%)
		LRR_8	152..210	CDD:290566	22/60 (37%)
		leucine-rich repeat	177..199	CDD:275380	8/23 (35%)
		LRR_8	198..256	CDD:290566	24/62 (39%)
		leucine-rich repeat	200..222	CDD:275380	6/21 (29%)
		leucine-rich repeat	223..245	CDD:275380	11/26 (42%)
		LRR_8	246..300	CDD:290566	14/58 (24%)
		leucine-rich repeat	246..268	CDD:275380	11/26 (42%)
		LRR_8	315..371	CDD:290566	18/57 (32%)
		leucine-rich repeat	315..337	CDD:275380	3/21 (14%)
		leucine-rich repeat	361..382	CDD:275380	6/23 (26%)
		PDZ	766..854	CDD:214570	14/59 (24%)
		PDZ_signaling	943..1032	CDD:238492
		PDZ_signaling	1139..1228	CDD:238492
		PDZ_signaling	1238..1327	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910