DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and LRIG3

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_700356.2	Gene:	LRIG3 / 121227	HGNCID:	30991	Length:	1119	Species:	Homo sapiens

Alignment Length:	1089	Identity:	211/1089 - (19%)
Similarity:	364/1089 - (33%)	Gaps:	319/1089 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVD-----------FSQLLAAM 74
            ||..:.||.::|.:..:      ::.|.:......||:.:..::::           .:.|..|.
Human    72 LPSWVARLDLSHNRLSF------IKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAG 130

  Fly    75 NTHARLKP--------VDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVL 131
            |....:.|        ::.|.::::.||||..| |..|.|..|.|:|..:..:..|.|....:.|
Human   131 NRIVEILPEHLKEFQSLETLDLSSNNISELQTA-FPALQLKYLYLNSNRVTSMEPGYFDNLANTL 194

  Fly   132 RNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT-LASNA 195
            ..|.|..|.::.:|.:..| |.:|..|:|::|::.::....|.||..|.:||:..|.|| |...|
Human   195 LVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGA 258

  Fly   196 FRGLEQ-----------------------SLKNLNLKGTKQRKV-PESIRGLKSLAFLDLSQNGI 236
            |.||..                       .|:.|:|......:: |::....:.|:.|||:.|.:
Human   259 FWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHL 323

  Fly   237 KELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLA---EFPIGAVH 298
            ..|..:.    |.||..|..|::..|.:..|.:.||.|: .:|.:|.|.||.::   |...||..
Human   324 SRLDDSS----FLGLSLLNTLHIGNNRVSYIADCAFRGL-SSLKTLDLKNNEISWTIEDMNGAFS 383

  Fly   299 SLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLH 363
            .|.:||.|.:..|.:.|:.:.||.|...:..|.|..|.:.|:...||:.:. .|:.|.|....|.
Human   384 GLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMK-KLQQLHLNTSSLL 447

  Fly   364 CDCKLRWVAEWIRNGDLQ--VTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDI---------- 416
            |||:|:|:.:|:...:.|  |.:.      |..|...:.|..:::.|:...|.|.
Human   448 CDCQLKWLPQWVAENNFQSFVNAS------CAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPE 506

  Fly   417 ADAALRGPVGLADNLK--PTLPSSPDS-------------------------------VEYET-- 446
            ..:|::|     .||.  .:..||.||                               :||.|
Human   507 TQSAIKG-----SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTIL 566

  Fly   447 --------GTG------TGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTR-RSTTRP 496
                    ..|      :...|:..:..|.:|.::..| .|.||...|....|..... .:...|
Human   567 RLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPS-FTKTPMDLTIRAGAMARLECAAVGHP 630

  Fly   497 PTKSTTTISATTASPAS-----------------NPPVNGTGTVQATSITTSSSSSSSSSTSTGH 544
            ..:........|..||:                 :..:...|....|:..::.|.|::::.:...
Human   631 APQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLE 695

  Fly   545 GNGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPPQRGTRIDDANEVQVKHAFRQDSS 609
            ......|...:.||.|........|||     .||     |....|:.|....|..:|.|...:.
Human   696 TPSFLRPLLDRTVTKGETAVLQCIAGG-----SPP-----PKLNWTKDDSPLVVTERHFFAAGNQ 750

  Fly   610 VIIQWDSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFKIKNVPAQECIIVCVISLEELHVTP 674
            ::|..|||                                 :.:.....|.:...:..|..:|..
Human   751 LLIIVDSD---------------------------------VSDAGKYTCEMSNTLGTERGNVRL 782

  Fly   675 ETVPYQQCREVRTVASQA-----SNMDKITIAASAAICGTIIVAVIVFIAASRRSRKLQ-SSQQK 733
            ..:|...|...:..|...     :.:..:.||....:.||.:|.|::.....||:.... ::..:
Human   783 SVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDE 847

  Fly   734 SPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHKEWDQVSAYSGRSIPRPRIYPVEQPDDMRSH 798
            :.|           |...|..|.|..||:    .::...||:.||
Human   848 TNL-----------PADIPSYLSSQGTLA----DRQDGYVSSESG-------------------- 877

  Fly   799 FSGMPGKVGKSRSLADGQSQHSFSNNSHRGYLGSAFPSNLVNSRPELRQSRQSLAAASERMSRAS 863
                              |.|.|..:|..|:.   .|.:..:....:..|.::...|:..:....
Human   878 ------------------SHHQFVTSSGAGFF---LPQHDSSGTCHIDNSSEADVEAATDLFLCP 921

  Fly   864 YAGSIHGGNGGGGGLGGNGGGGGNGLPVSSLMAMSGMVGGGGPASIASSARRSRPR--------- 919
            :.||                        :..|.:.|.|.|..|.....:.....||
Human   922 FLGS------------------------TGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEP 962

  Fly   920 -----------------------------SRSREQLNTTHIHNHRPGSR 939
                                         |..|:.|||::.||..||.:
Human   963 SYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMK 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	57/243 (23%)
		leucine-rich repeat	86..105	CDD:275380	7/18 (39%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	18/57 (32%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	11/46 (24%)
		leucine-rich repeat	203..225	CDD:275380	4/22 (18%)
		leucine-rich repeat	226..253	CDD:275380	9/26 (35%)
		LRR_8	254..337	CDD:338972	27/85 (32%)
		leucine-rich repeat	254..302	CDD:275380	16/50 (32%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		PCC	332..>413	CDD:188093	21/82 (26%)
		PRK10927	<1061..>1097	CDD:236797
LRIG3	NP_700356.2	LRR	20..395	CDD:227223	83/335 (25%)
		leucine-rich repeat	58..74	CDD:275378	1/1 (100%)
		LRR_RI	<65..>245	CDD:238064	41/180 (23%)
		LRR 1	75..96		4/26 (15%)
		leucine-rich repeat	78..99	CDD:275378	4/26 (15%)
		LRR 2	99..120		2/20 (10%)
		leucine-rich repeat	100..115	CDD:275378	2/14 (14%)
		LRR 3	122..142		4/19 (21%)
		leucine-rich repeat	123..146	CDD:275378	4/22 (18%)
		LRR 4	146..167		7/21 (33%)
		leucine-rich repeat	147..168	CDD:275380	7/21 (33%)
		LRR 5	168..189		6/20 (30%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		LRR 6	193..214		6/21 (29%)
		leucine-rich repeat	194..216	CDD:275380	7/22 (32%)
		LRR 7	216..237		5/20 (25%)
		leucine-rich repeat	217..240	CDD:275380	7/22 (32%)
		LRR 8	240..261		9/20 (45%)
		leucine-rich repeat	241..264	CDD:275380	11/22 (50%)
		LRR_RI	262..>446	CDD:238064	47/189 (25%)
		LRR 9	264..285		0/20 (0%)
		leucine-rich repeat	265..288	CDD:275380	0/22 (0%)
		LRR 10	288..309		4/20 (20%)
		leucine-rich repeat	289..312	CDD:275380	4/22 (18%)
		LRR 11	312..333		7/24 (29%)
		leucine-rich repeat	313..336	CDD:275380	9/26 (35%)
		LRR 12	336..357		6/20 (30%)
		leucine-rich repeat	337..360	CDD:275380	7/23 (30%)
		LRR 13	360..382		7/21 (33%)
		leucine-rich repeat	361..385	CDD:275380	8/23 (35%)
		LRR_8	387..442	CDD:290566	16/55 (29%)
		LRR 14	387..408		7/20 (35%)
		leucine-rich repeat	388..411	CDD:275380	8/22 (36%)
		LRR 15	411..432		6/20 (30%)
		leucine-rich repeat	412..435	CDD:275380	6/23 (26%)
		LRRCT	446..494	CDD:214507	13/53 (25%)
		Ig_3	498..585	CDD:290638	12/91 (13%)
		I-set	499..599	CDD:254352	14/104 (13%)
		I-set	603..693	CDD:254352	14/90 (16%)
		Ig_1	620..694	CDD:143240	8/73 (11%)
		I-set	697..784	CDD:254352	22/129 (17%)
		IGc2	711..774	CDD:197706	17/105 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1073..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910