DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and gp5

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_031758900.1	Gene:	gp5 / 116411101	-ID:	-	Length:	615	Species:	Xenopus tropicalis

Alignment Length:	613	Identity:	149/613 - (24%)
Similarity:	221/613 - (36%)	Gaps:	177/613 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLKPVDLLY 87
            ||...|....|.||...:. ||:.:.||     |..|::    |...||...|       ...::
Frog     8 LIATHLLFVGATCPTLCNC-DLKDAIIC-----RGTSIK----DIGSLLLPSN-------FTYIH 55

  Fly    88 VNNSTISELPDAVFSNL-------------------------SLHNLQLSSCGIQRIATGAFKGQ 127
            :..:..:|:.|..|.|:                         .|.:|:|:...::.:..|.|...
Frog    56 IMETLATEITDKSFGNMPVTLRLRLEANHLTSITRNAFKSFPHLKSLKLTDNKLKTLPAGMFDSL 120

  Fly   128 ESV-----------------------LRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIP 169
            .|:                       |..|.|..|.|..:|.|.||.|.||..|:||:|::||:|
Frog   121 ISLEQLFLDKNCLSSLHPNLFCCLQHLEELILNRNQLTSLPDELLKNLTKLISLNLSRNKISHLP 185

  Fly   170 DDAFVGLTKLSTLKLNDNN-VTLASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQ 233
            ...|..||||..|.|.||. ||:.|:||..|.:.|.......:.|....::...|..|..|.||:
Frog   186 MSIFSSLTKLKKLFLYDNQLVTITSSAFNKLGELLDLALYSNSIQFVAQDAFYHLPKLQSLKLSK 250

  Fly   234 NGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVH 298
            |.::.||    ..:|..|..|:.|.|..|.::.:.:..| |..:.|:||.|.|..|...|.....
Frog   251 NKLQLLP----YGLFLHLPQLSTLTLYDNPLKELPDVLF-GKMENLTSLWLYNTHLTTIPNFVFC 310

  Fly   299 SLKELRVLDIGFNL-LTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHL-------------- 348
            :|..|::|.:..|. |.|||:.||.|...:..|:|..|.|||:....|.:|
Frog   311 NLTNLQLLVLTRNAQLDSLPKEAFSGLNNLLELSLHSNNLSSIDNDVFQNLQLLEKLSLYSNNLK 375

  Fly   349 -------------------NATLRGL---------SLGGRFLH-----CDCKLRWVAEWIRNGDL 380
                               |:.|..|         ||...:||     |.|:|.....|.:
Frog   376 VLSENMFYNLTKLQILHLNNSNLHTLPGQIFQELPSLQMVYLHSNPWACYCELTDFKMWFQ---- 436

  Fly   381 QVTSRERNPQ--FCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVE 443
            |..::..||.  .|.||               .:..:|:                .|.:......
Frog   437 QNQNKVYNPMSLVCDTP---------------FTLSNIS----------------VLAAGESICH 470

  Fly   444 YETGTGTGTVGTGTAASAPVTSSVSSSTS---------TTTP---TTTTTTTTAEPTTRRST--- 493
            |.|....   ...|.|::..||::.|:.|         .|.|   ||:.|.||.|..|.::|
Frog   471 YTTAKQN---NLDTTANSQTTSNIQSTYSYNNIEFTNVKTQPISYTTSPTATTWETRTIKNTVFF 532

  Fly   494 TRPPTKSTTTISATTASP---ASNPPVN 518
            ...||.:...::|....|   .||.|.|
Frog   533 VMIPTTAIQDLNAGVLKPIPYVSNVPYN 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	61/248 (25%)
		leucine-rich repeat	86..105	CDD:275380	4/43 (9%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		LRR_8	131..189	CDD:338972	28/58 (48%)
		leucine-rich repeat	131..154	CDD:275380	10/22 (45%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	11/23 (48%)
		leucine-rich repeat	203..225	CDD:275380	3/21 (14%)
		leucine-rich repeat	226..253	CDD:275380	9/26 (35%)
		LRR_8	254..337	CDD:338972	27/83 (33%)
		leucine-rich repeat	254..302	CDD:275380	14/47 (30%)
		leucine-rich repeat	303..326	CDD:275380	10/23 (43%)
		leucine-rich repeat	327..350	CDD:275380	8/55 (15%)
		PCC	332..>413	CDD:188093	24/129 (19%)
		PRK10927	<1061..>1097	CDD:236797
gp5	XP_031758900.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910