DRSC/TRiP Functional Genomics Resources

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Protein Alignment haf and Lgr4

DIOPT Version :9

Sequence 1:NP_001356954.1 Gene:haf / 33339 FlyBaseID:FBgn0261509 Length:1347 Species:Drosophila melanogaster
Sequence 2:NP_766259.2 Gene:Lgr4 / 107515 MGIID:1891468 Length:951 Species:Mus musculus


Alignment Length:335 Identity:109/335 - (32%)
Similarity:153/335 - (45%) Gaps:58/335 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 LYVNNSTISELPDAVFSNLS------LHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADV 144
            |.:||  ||.:||..|:|||      |||.::.|     ::...|.|.:: |..|:|..|.|.:.
Mouse   184 LALNN--ISSIPDFAFTNLSSLVVLHLHNNKIKS-----LSQHCFDGLDN-LETLDLNYNNLDEF 240

  Fly   145 PVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASN-AFRGLEQ------- 201
            | :|:|.|..|..|....|.:|.|||.||.|...|.|:.|.||.::...| ||..|..       
Mouse   241 P-QAIKALPSLKELGFHSNSISVIPDGAFAGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIR 304

  Fly   202 ---------------SLKNLNLKGTKQRKVPESI-RGLKSLAFLDLSQNGIKELPGAGGIRVFDG 250
                           .|::|.|.|||...:|:.: :..|.|..||||.|.|::||.      |:|
Mouse   305 GASLVQWFPNLAGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLSYNDIRDLPS------FNG 363

  Fly   251 LDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTS 315
            ..||..::|:||.|..|.||.|.|: .:|..|.|..||:.|...||...|..:..||:.||.|||
Mouse   364 CRALEEISLQRNQISLIKETTFQGL-TSLRILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTS 427

  Fly   316 LPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDL 380
            .|.   .|..|:..|.|.||  ..:.:...|...|.||.||:...:..|       |.|..:...
Mouse   428 FPT---EGLNGLNQLKLVGN--FQLKDALAARDFANLRSLSVPYAYQCC-------AFWGCDSYA 480

  Fly   381 QVTSRERNPQ 390
            .:.:.:.:||
Mouse   481 NLNTEDNSPQ 490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hafNP_001356954.1 LRR <52..>252 CDD:227223 64/195 (33%)
leucine-rich repeat 86..105 CDD:275380 9/18 (50%)
leucine-rich repeat 106..129 CDD:275380 6/22 (27%)
LRR_8 131..189 CDD:338972 24/57 (42%)
leucine-rich repeat 131..154 CDD:275380 9/22 (41%)
leucine-rich repeat 155..178 CDD:275380 10/22 (45%)
leucine-rich repeat 179..202 CDD:275380 9/45 (20%)
leucine-rich repeat 203..225 CDD:275380 7/22 (32%)
leucine-rich repeat 226..253 CDD:275380 11/26 (42%)
LRR_8 254..337 CDD:338972 33/82 (40%)
leucine-rich repeat 254..302 CDD:275380 19/47 (40%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
leucine-rich repeat 327..350 CDD:275380 5/22 (23%)
PCC 332..>413 CDD:188093 14/59 (24%)
PRK10927 <1061..>1097 CDD:236797
Lgr4NP_766259.2 LRRNT 29..61 CDD:214470
LRR 1 58..79
leucine-rich repeat 59..82 CDD:275380
LRR 2 82..103
LRR_RI 83..375 CDD:238064 67/205 (33%)
LRR_8 83..141 CDD:290566
leucine-rich repeat 83..106 CDD:275380
LRR 3 106..127
leucine-rich repeat 107..130 CDD:275380
LRR 4 130..151
leucine-rich repeat 131..154 CDD:275380
LRR 5 154..177
leucine-rich repeat 155..178 CDD:275380
LRR_8 177..237 CDD:290566 21/60 (35%)
LRR 6 178..199 8/16 (50%)
leucine-rich repeat 179..202 CDD:275380 10/19 (53%)
LRR 7 202..223 5/25 (20%)
leucine-rich repeat 203..226 CDD:275380 6/27 (22%)
LRR 8 226..247 8/22 (36%)
leucine-rich repeat 227..249 CDD:275380 9/22 (41%)
LRR_8 248..305 CDD:290566 19/56 (34%)
LRR 9 249..270 9/20 (45%)
leucine-rich repeat 250..273 CDD:275380 10/22 (45%)
LRR_8 272..355 CDD:290566 23/82 (28%)
LRR 10 273..294 8/20 (40%)
leucine-rich repeat 274..295 CDD:275380 8/20 (40%)
LRR 11 320..341 7/20 (35%)
leucine-rich repeat 321..344 CDD:275380 7/22 (32%)
LRR 12 344..365 11/26 (42%)
leucine-rich repeat 345..366 CDD:275380 11/26 (42%)
LRR_8 365..425 CDD:290566 24/60 (40%)
LRR 13 366..387 10/20 (50%)
leucine-rich repeat 367..390 CDD:275380 10/23 (43%)
LRR 388..410 CDD:197688 8/22 (36%)
LRR 14 390..411 8/20 (40%)
leucine-rich repeat 391..414 CDD:275380 9/22 (41%)
LRR 15 414..435 9/23 (39%)
leucine-rich repeat 415..438 CDD:275380 10/25 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..512 2/4 (50%)
7tm_1 556..801 CDD:278431
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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