DRSC/TRiP Functional Genomics Resources

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Protein Alignment haf and Islr2

DIOPT Version :9

Sequence 1:NP_001356954.1 Gene:haf / 33339 FlyBaseID:FBgn0261509 Length:1347 Species:Drosophila melanogaster
Sequence 2:XP_003750572.2 Gene:Islr2 / 100910729 RGDID:6497037 Length:746 Species:Rattus norvegicus


Alignment Length:509 Identity:115/509 - (22%)
Similarity:178/509 - (34%) Gaps:114/509 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 RKVPESIRGLKSLAFLDLSQNGIKEL-PGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRK 277
            |:|||.:..  ::..|.||.|.|..| .||     |..:..:|:|.|..:.::::...|.| |..
  Rat    44 REVPEGLPA--N
VTTLSLSANKITVLRRGA-----FVNVTQVTSLWLAHSEVRTVESGALA-VLS 100

  Fly   278 TLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPE 342
            .|.:|.|.:||::.||...:.:|..|::|.:..|.|.|||..|....|.:..|.::.|.|.::..
  Rat   101 QLKNLDLSHNLISNFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLEP 165

  Fly   343 GAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQ 407
            |.|..|:| |..|.|.....||.|.|.|:..|.  ...:|:..|.:...|.:||..:....:.: 
  Rat   166 GTFDALSA-LSHLQLYHNPFHCSCGLVWLQAWA--ASTRVSLPEPDSIACASPPELQGVPVHRL- 226

  Fly   408 PEELSC------------PDIADAALRG------------------------PVGLADNLKPTLP 436
             ..|.|            |:.....||.                        |.|....:.|.|.
  Rat   227 -PALPCAPPSVRLSAEPPPEAPGTPLRAGLSFLLHCVAEGHPTPRLQWQLQIPGGTVVLVPPVLS 290

  Fly   437 SSPDSVE-YETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKS 500
            ...|..| .:.|.|.|.....|...||            |||..........|.|.......:..
  Rat   291 KEEDGGEKVDDGEGDGDEDQPTQTEAP------------TPTPAPAWPAPPATPRFLALANGSLL 343

  Fly   501 TTTISATTASPASNPPVNGTGTVQATS--ITTSSSSSSSSSTSTGHGNGKQAP-GWRQGVTNGNG 562
            ...:||..|...:....|..|| .:||  :|.:::.....:..||.....||| ..|:..|.|..
  Rat   344 VPLLSAKEAGIYTCRAHNELGT-NSTSLRVTVAAAGPPKHAPGTGEEPDAQAPTSERKATTKGRS 407

  Fly   563 NSGVGGAGGLHKPQRPPLVLGYPPQRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANILGFRVV 627
            ||                ||.:.|:..|:......|.:......:..     ::|....:|.::.
  Rat   408 NS----------------VLPFKPEGKTKGQGLARVSILGETEAELE-----ETDEEEQMGGQIP 451

  Fly   628 YRLFGEKAFKQGPP--------------------------LESSEREFKIKNVP 655
            ....|||....|.|                          |:.:|||.:::..|
  Rat   452 ADPMGEKHCGHGDPSRYVSNHAFNQSSDLKPHVFELGVIALDVAEREARVQLTP 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hafNP_001356954.1 LRR <52..>252 CDD:227223 13/38 (34%)
leucine-rich repeat 86..105 CDD:275380
leucine-rich repeat 106..129 CDD:275380
LRR_8 131..189 CDD:338972
leucine-rich repeat 131..154 CDD:275380
leucine-rich repeat 155..178 CDD:275380
leucine-rich repeat 179..202 CDD:275380
leucine-rich repeat 203..225 CDD:275380 4/10 (40%)
leucine-rich repeat 226..253 CDD:275380 9/27 (33%)
LRR_8 254..337 CDD:338972 25/82 (30%)
leucine-rich repeat 254..302 CDD:275380 14/47 (30%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 6/22 (27%)
PCC 332..>413 CDD:188093 21/80 (26%)
PRK10927 <1061..>1097 CDD:236797
Islr2XP_003750572.2 leucine-rich repeat 37..53 CDD:275380 4/10 (40%)
leucine-rich repeat 54..77 CDD:275380 9/27 (33%)
leucine-rich repeat 78..101 CDD:275380 6/23 (26%)
LRR_8 100..160 CDD:404697 19/59 (32%)
leucine-rich repeat 102..125 CDD:275380 8/22 (36%)
leucine-rich repeat 126..149 CDD:275380 8/22 (36%)
leucine-rich repeat 150..173 CDD:275380 6/22 (27%)
PCC 155..>229 CDD:188093 20/78 (26%)
Ig 249..374 CDD:416386 27/137 (20%)
Ig strand B 257..264 CDD:409353 0/6 (0%)
Ig strand C 270..278 CDD:409353 0/7 (0%)
Ig strand C' 280..287 CDD:409353 1/6 (17%)
Ig strand D 333..337 CDD:409353 1/3 (33%)
Ig strand E 340..345 CDD:409353 0/4 (0%)
Ig strand F 353..361 CDD:409353 0/7 (0%)
Ig strand G 364..374 CDD:409353 4/10 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24366
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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