DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and LOC100495962

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_004912402.2	Gene:	LOC100495962 / 100495962	-ID:	-	Length:	1055	Species:	Xenopus tropicalis

Alignment Length:	366	Identity:	91/366 - (24%)
Similarity:	144/366 - (39%)	Gaps:	87/366 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 FSNLSLHNLQLSSCGIQRIATGAFKGQESV-LRNLNLQD---NLLADVPVEALKVLGKLNLLDLS 161
            ||::|.  |.|||.||.:    ...|.|.: |:||...|   |.|....:.|.:.|..|.:||||
Frog   520 FSDVSC--LNLSSNGIGQ----DLNGTEFIYLKNLTYLDLSFNKLDFDSINAFQELPSLEVLDLS 578

  Fly   162 KNQLSHIPDDA-----FV-GLTKLSTLKLNDNNVTLASNAFRGLEQSLKNLNLKGTK-------- 212
            .|....|.|..     |: .|..|..|.|:.|.::..:: ||....|||.|...|.:
Frog   579 YNSHYFIVDGVIHSLKFIENLQHLKVLNLSWNKISTLTD-FRLTSHSLKELQFSGNRLDVLWKNE 642

  Fly   213 QRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIR----------------VFDGLDALTA----- 256
            .::..:....|.||..||:|.|.:.::.|.  :|                |:.|.:.|.|
Frog   643 DKRYHKLFMNLSSLTCLDISYNRLSKIKGE--LRYLPLSLTELYLNSNELVYFGWEELQAYENLK 705

  Fly   257 -LNLERN-LIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEA 319
             |:|..| |...:|..:..  ..:||||.:..|.::..|:..:|..:.|..||:.||.|.|:..:
Frog   706 YLDLSHNKLTMIMGNLSIH--TYSLSSLIISYNSISSLPVAFLHKARNLSELDLSFNHLKSINSS 768

  Fly   320 A-FRGNPG-ITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQV 382
            . ..|:.. :.:|.|.|||..                         |.|::.....||...::.:
Frog   769 VLLSGSENYLKVLGLKGNPFV-------------------------CTCEITDFISWIYANNVTI 808

  Fly   383 TSRERNPQFCGTPPRFRDRG--FYSIQPEELSCPDIADAAL 421
             .|......|.||...:..|  ::.:.    :| |:..||:
Frog   809 -PRLATDVNCATPENKKGSGIIYFDVH----TC-DLDGAAM 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	51/184 (28%)
		leucine-rich repeat	86..105	CDD:275380	2/3 (67%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		LRR_8	131..189	CDD:338972	22/66 (33%)
		leucine-rich repeat	131..154	CDD:275380	8/25 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/28 (36%)
		leucine-rich repeat	179..202	CDD:275380	6/22 (27%)
		leucine-rich repeat	203..225	CDD:275380	5/29 (17%)
		leucine-rich repeat	226..253	CDD:275380	9/42 (21%)
		LRR_8	254..337	CDD:338972	26/91 (29%)
		leucine-rich repeat	254..302	CDD:275380	14/54 (26%)
		leucine-rich repeat	303..326	CDD:275380	8/23 (35%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		PCC	332..>413	CDD:188093	13/82 (16%)
		PRK10927	<1061..>1097	CDD:236797
LOC100495962	XP_004912402.2	LRR_8	81..151	CDD:404697
		leucine-rich repeat	81..102	CDD:275380
		leucine-rich repeat	103..140	CDD:275380
		leucine-rich repeat	141..160	CDD:275380
		PLN00113	153..>580	CDD:215061	24/65 (37%)
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..217	CDD:275380
		leucine-rich repeat	218..262	CDD:275380
		leucine-rich repeat	263..303	CDD:275380
		leucine-rich repeat	304..327	CDD:275380
		leucine-rich repeat	328..353	CDD:275380
		leucine-rich repeat	354..383	CDD:275380
		leucine-rich repeat	384..410	CDD:275380
		leucine-rich repeat	411..434	CDD:275380
		leucine-rich repeat	500..522	CDD:275380	1/1 (100%)
		leucine-rich repeat	526..547	CDD:275380	9/24 (38%)
		PPP1R42	545..788	CDD:411060	66/247 (27%)
		leucine-rich repeat	548..571	CDD:275380	6/22 (27%)
		leucine-rich repeat	572..601	CDD:275380	10/28 (36%)
		leucine-rich repeat	602..624	CDD:275380	6/22 (27%)
		leucine-rich repeat	625..655	CDD:275380	5/29 (17%)
		leucine-rich repeat	656..679	CDD:275380	7/24 (29%)
		leucine-rich repeat	680..703	CDD:275380	4/22 (18%)
		leucine-rich repeat	704..727	CDD:275380	5/24 (21%)
		leucine-rich repeat	728..751	CDD:275380	7/22 (32%)
		leucine-rich repeat	752..770	CDD:275380	7/17 (41%)
		TPKR_C2	786..>825	CDD:417692	10/64 (16%)
		TIR_2	893..1030	CDD:419986
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910