DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and lrig2

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_002932176.2	Gene:	lrig2 / 100494845	XenbaseID:	XB-GENE-922899	Length:	1078	Species:	Xenopus tropicalis

Alignment Length:	1109	Identity:	235/1109 - (21%)
Similarity:	357/1109 - (32%)	Gaps:	307/1109 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RTTTALPAATTPL-LLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFS 68
            |....||||..|. :..|.:....|.|:::..     ||:|             .|:|..:::|:
Frog    44 RRLARLPAAPLPEGITSLEISYNWLTVSNSSL-----VPEL-------------YSLQEVKMNFN 90

  Fly    69 QLLAAMNTHARLKPVDLLYVNNSTISEL-PDAVFSNLSLHNLQLSS------------------- 113
            :|.|..:.......:.||.:.::.|.|| .|.:...|||..|.|||
Frog    91 ELTAIPHLGEPTANITLLSLVHNKIGELNGDLLQQYLSLETLDLSSNLLTEIKSFYFPRMPLKYL 155

  Fly   114 -CGIQRIAT---GAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFV 174
             ....||||   |.|....|.|..|.|..|.:..:..::.| |..|..|:|.:|::..:....|.
Frog   156 NLSNNRIATLEAGCFDNLSSSLLVLKLNRNRINVIQPKSFK-LPHLQYLELRRNRIKIVESLTFQ 219

  Fly   175 GLTKLSTLKLNDNN-VTLASNAFRGLEQSLKNLNLKGTKQRKVPES-IRGLKSLAFLDLSQNGIK 237
            ||..|.:|||..|. |.|...||.||: :::.|.|:......:.:. :.||:||..|.:|||.:.
Frog   220 GLDSLKSLKLQRNGIVKLMDGAFFGLD-NMEQLELEYNNVTDINKGWLYGLRSLQQLYISQNAVH 283

  Fly   238 EL-PGAGGI-------------------RVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSL 282
            .: |.|...                   ..|.||.:|..:||..|.|..|.|..|.|:...| .|
Frog   284 RISPDAWEFCQKLLDLDLSYNQLNRLDDFAFVGLSSLEKINLGDNRINHIAEGVFKGLANLL-VL 347

  Fly   283 SLLNNLLA---EFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGA 344
            .|.||.::   |........|..|..|.:..|.:.|:...||.|...:..|.|..|.:.||.|..
Frog   348 DLRNNEISWAIEDSNEVFAGLSRLHTLILQGNKIKSITMKAFTGLDSLQHLDLSNNAILSVQENG 412

  Fly   345 FAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQF----CGTPPRFRDRGFYS 405
            |:.:.  |:.|.|....|.|||:|:|...|:.:....        ||    |..|.....|...|
Frog   413 FSFMK--LQELILNTSNLLCDCQLKWFPHWLNDNGFH--------QFVNVSCAHPNWLAGRSPLS 467

  Fly   406 IQPEELSCPDIADAALRGPVGLADNL-KPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSVSS 469
            :..|:..|               ||. ||.:...|::             |.......|:.:.::
Frog   468 VDAEDFIC---------------DNFPKPQIKLQPET-------------TVALKGMNVSLTCAA 504

  Fly   470 STSTTTPTTTTTTTTAE---PTTRRSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITTS 531
            ::|:.||.:|......|   .....:..|........|...|.....|......|..|.......
Frog   505 ASSSDTPMSTAWRKDGEVLYDAEVENFARYHKHGIELIEYITVLHLFNVNFTDEGKYQCVITNHF 569

  Fly   532 SSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPPQRGTRIDDAN 596
            .|:.||.:..|.:    :.|.:.:...:....:|............||..:.:....||....|.
Frog   570 GSNYSSKAKLTVN----EMPSFLKTPMDLTIRTGAMARLECAAEGHPPPQIAWQKDGGTDFPAAR 630

  Fly   597 EVQVKHAFRQDSSVII-----------------QWDSDTANI-------------LGFRVVYRLF 631
            |.:: |...:|..:.|                 ...|.:||:             |..|.|.|
Frog   631 ERRM-HVMPEDEVLFIVNVKIEDMGLYSCTAQNAAGSISANVTLTVLETPSFVRPLEDRTVAR-- 692

  Fly   632 GEKAF----------------KQGPPLESSEREFKIKNVPAQECIIV------------CVIS-- 666
            ||.|.                |...||:.:||.|   ...|.:.:|:            |.:|
Frog   693 GETAVLHCIAGGSPAPRLNWTKDDGPLQVTERHF---FAAANQLLIIVDAGPEDAGKYTCSMSNT 754

  Fly   667 --LEELHVTPETVPYQQCREVRTVASQASNMDKITIAASAAIC---GTIIVAVIVFIAASRRSRK 726
              .|..|:....:....|...:.:..:......:.|.....:|   ||.:|.|||.....|:|..
Frog   755 LGTERGHINLHVLSSPNCDSSQNIGYEEDGWTTVGIVIIVVVCCVVGTSLVWVIVIYHMRRKSED 819

  Fly   727 LQSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHKEWDQVSAYSGRSIPRPRIYPVEQ 791
            ...:..:.        :|.  |...|..|.|..|||        :....||.
Frog   820 YSITNTED--------MNL--PADIPSYLSSQGTLS--------EPPEGYSN------------- 853

  Fly   792 PDDMRSHFSGMPGKVGKSRSLADGQSQHSFSNNS-HRG---------------YLGSAFPSNLVN 840
             .:..||...||.                 :||. |:|               .|.:.|..|:..
Frog   854 -SEAGSHQQLMPP-----------------ANNCVHKGTDGLYVDTGSEADMDILNTPFSHNMQG 900

  Fly   841 SRPELRQSRQSLAAASERMSRASYAGSIHGGNGGGGGLGGNGGGGGNGLPV---SSLMAMSGMVG 902
            ..|.|.....::.....|                            .|||:   :.||..|....
Frog   901 KMPHLYSGHGTILPTDTR----------------------------EGLPIPAAAPLMICSDCYD 937

  Fly   903 GGGPASIASSARRSRPRSRSRE----------QLNTTHIHNHRPGSRYSQAGS--TH----TLNN 951
            .   |:|.|..|...|.:...|          |:....::.|...|......|  :|    :.|.
Frog   938 N---ANIYSRTREFYPYTYITEEDQILPSLIAQIPKETLYQHEVLSERDMRASLTSHDRLDSTNP 999

  Fly   952 YCDT 955
            .|||
Frog  1000 SCDT 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	63/245 (26%)
		leucine-rich repeat	86..105	CDD:275380	5/19 (26%)
		leucine-rich repeat	106..129	CDD:275380	11/45 (24%)
		LRR_8	131..189	CDD:338972	18/58 (31%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	11/23 (48%)
		leucine-rich repeat	203..225	CDD:275380	4/22 (18%)
		leucine-rich repeat	226..253	CDD:275380	10/46 (22%)
		LRR_8	254..337	CDD:338972	26/85 (31%)
		leucine-rich repeat	254..302	CDD:275380	16/50 (32%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	23/84 (27%)
		PRK10927	<1061..>1097	CDD:236797
lrig2	XP_002932176.2	PRK15370	<37..>165	CDD:185268	33/138 (24%)
		leucine-rich repeat	37..56	CDD:275380	5/11 (45%)
		leucine-rich repeat	58..81	CDD:275380	6/40 (15%)
		leucine-rich repeat	82..104	CDD:275380	4/21 (19%)
		leucine-rich repeat	105..128	CDD:275378	6/22 (27%)
		LRR	127..>384	CDD:227223	72/259 (28%)
		leucine-rich repeat	129..148	CDD:275380	5/18 (28%)
		leucine-rich repeat	152..175	CDD:275380	6/22 (27%)
		leucine-rich repeat	176..199	CDD:275380	6/23 (26%)
		leucine-rich repeat	200..223	CDD:275380	7/22 (32%)
		leucine-rich repeat	224..247	CDD:275380	11/23 (48%)
		leucine-rich repeat	248..271	CDD:275380	4/22 (18%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	3/22 (14%)
		leucine-rich repeat	320..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..368	CDD:275380	6/24 (25%)
		LRR_8	370..429	CDD:338972	17/60 (28%)
		leucine-rich repeat	371..394	CDD:275380	7/22 (32%)
		leucine-rich repeat	395..417	CDD:275380	7/21 (33%)
		LRRCT	428..476	CDD:214507	15/70 (21%)
		Ig	485..581	CDD:386229	17/108 (16%)
		Ig_1	602..676	CDD:143240	12/74 (16%)
		I-set	679..766	CDD:369462	19/91 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910