DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and tlr9

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_017948709.2	Gene:	tlr9 / 100494387	XenbaseID:	XB-GENE-486908	Length:	1035	Species:	Xenopus tropicalis

Alignment Length:	378	Identity:	86/378 - (22%)
Similarity:	137/378 - (36%)	Gaps:	85/378 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 VDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVE 147
            |||.:.|..:|  .||.......:..|.:|...|.:...|...|....||:|:|..|.......:
Frog   484 VDLSFNNIGSI--YPDEFLGMDEIECLNMSYNYINQRLNGTQFGHLKSLRHLDLSHNRFDMYYYK 546

  Fly   148 ALKVLGKLNLLDLSKNQLSHIPD------DAFVGLTKLSTLKLNDNNVTLASNAFRGLEQSLKNL 206
            ||..|.:|.:|:|:.|....:..      |....||.|..|.||:|.:.|.      :.:.||:.
Frog   547 ALSELPRLKILNLAHNDYQFMMKGVNHRLDFLENLTSLVELNLNNNFIGLR------ITRELKSH 605

  Fly   207 NLKGTKQRK-------------VPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALN 258
            :|:..:.|.             .......|:||..||:|.|.:..:|
Frog   606 SLETLRFRNNELGSSWQYGKDTYLNMFTNLRSLKILDISYNQLPVIP------------------ 652

  Fly   259 LERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRG 323
              ..:::.:.|        :|..|:|.:|.|..|.......|..|.:||:|||.||.|.......
Frog   653 --NEVLEKLPE--------SLQKLNLSHNKLYTFNWAKTAHLGNLAILDLGFNALTKLRANLTES 707

  Fly   324 NPGITLLALDGNPLSSVPEGAF------------------AHLNA-------TLRGLSLGGRFLH 363
            |  |..|.|..|.::|:.:..|                  .|:.:       .|..|.:.|....
Frog   708 N--IAFLNLTYNKINSLDKDFFDSFSELKQLILSNNLIKTIHITSFPINFLQNLDSLDVSGNPFQ 770

  Fly   364 CDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDI 416
            |.||..|...::...::.|.......: |.:|...|.|...|:.|:  ||.::
Frog   771 CTCKAYWFITFLMETEVTVDHLSTGMK-CDSPDSLRGRSLLSMDPQ--SCQEL 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	45/187 (24%)
		leucine-rich repeat	86..105	CDD:275380	4/18 (22%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		LRR_8	131..189	CDD:338972	20/63 (32%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		leucine-rich repeat	155..178	CDD:275380	6/28 (21%)
		leucine-rich repeat	179..202	CDD:275380	6/22 (27%)
		leucine-rich repeat	203..225	CDD:275380	5/34 (15%)
		leucine-rich repeat	226..253	CDD:275380	6/26 (23%)
		LRR_8	254..337	CDD:338972	22/82 (27%)
		leucine-rich repeat	254..302	CDD:275380	8/47 (17%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	7/40 (18%)
		PCC	332..>413	CDD:188093	19/105 (18%)
		PRK10927	<1061..>1097	CDD:236797
tlr9	XP_017948709.2	leucine-rich repeat	69..92	CDD:275380
		PLN00113	82..>592	CDD:215061	31/109 (28%)
		leucine-rich repeat	93..128	CDD:275380
		leucine-rich repeat	129..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		leucine-rich repeat	173..203	CDD:275380
		leucine-rich repeat	204..224	CDD:275380
		leucine-rich repeat	225..248	CDD:275380
		leucine-rich repeat	249..289	CDD:275380
		leucine-rich repeat	290..311	CDD:275380
		leucine-rich repeat	314..337	CDD:275380
		leucine-rich repeat	353..394	CDD:275380
		leucine-rich repeat	395..418	CDD:275380
		leucine-rich repeat	482..504	CDD:275380	7/21 (33%)
		leucine-rich repeat	505..529	CDD:275380	5/23 (22%)
		leucine-rich repeat	530..553	CDD:275380	8/22 (36%)
		inl_like_NEAT_1	<534..>767	CDD:411101	57/268 (21%)
		leucine-rich repeat	554..583	CDD:275380	6/28 (21%)
		leucine-rich repeat	584..637	CDD:275380	11/58 (19%)
		leucine-rich repeat	607..629	CDD:275380	2/21 (10%)
		leucine-rich repeat	638..662	CDD:275380	7/51 (14%)
		leucine-rich repeat	663..686	CDD:275380	7/22 (32%)
		leucine-rich repeat	687..708	CDD:275380	9/20 (45%)
		leucine-rich repeat	709..732	CDD:275380	6/22 (27%)
		leucine-rich repeat	733..751	CDD:275380	1/17 (6%)
		PCC	738..>821	CDD:188093	17/86 (20%)
		TIR_2	875..1017	CDD:419986
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910