DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and lrig1

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_002938412.1	Gene:	lrig1 / 100491453	XenbaseID:	XB-GENE-494193	Length:	1043	Species:	Xenopus tropicalis

Alignment Length:	866	Identity:	198/866 - (22%)
Similarity:	306/866 - (35%)	Gaps:	209/866 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPAATTPLLLLLPLILGRLHVAHAQCPWQRDV----------PDLQTSC--ICAYNLGRELSVQC 62
            |||.|..|.|....:......|.||.|..|:|          |.|.|:.  :...:|...   :.
Frog    53 LPAWTVHLNLSSNKLKEIDPAAFAQLPELREVHLGHNELTGIPHLGTAAPQVTTLSLHHN---KI 114

  Fly    63 DQVDFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVF-SNLSLHNLQLSSCGIQRIATGAFKG 126
            ..:|.|||    ..:..|:.:||   :::.::|:....| :.|.:..|.|.|..|..:..|:|..
Frog   115 RSIDPSQL----KPYVALETLDL---SSNELTEIRSGSFPAGLRIKELHLGSNKISSLEPGSFDS 172

  Fly   127 QESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT- 190
            ....|..|.|..|.::.:||:..: |.:|..|:|::|::..|....|.||..|..|||..||::
Frog   173 LSRSLLTLRLSKNRISQLPVKVFR-LPRLTQLELNRNRIRLIEGLTFQGLESLEVLKLQRNNISK 236

  Fly   191 LASNAFRGLEQSLKNLNLKGTKQRKVPE-SIRGLKSLAFLDLSQNGIKELPGAGG---------- 244
            |...||.||.: ::.|:|:.....:|.. |:.||.||..|.||.|.|..:..||.
Frog   237 LTDGAFWGLSR-MQILHLENNSLTEVNSGSLYGLLSLQQLHLSHNSISTISSAGWSFCQKLQELV 300

  Fly   245 ------IRVFDG----LDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLA---EFPIGA 296
                  .|:.:|    |..|..|.|..|.|..|.|.||.|: |:|..|.|.:|.::   |...||
Frog   301 LSHNNLTRLDEGSLADLGVLDVLRLSYNSISHIAEGAFKGL-KSLRILELDHNEISGTIEDTNGA 364

  Fly   297 VHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRF 361
            ...|:.|..|.:..|.:.|:.:.||.|...:..|.|..|.|.||...||..:. .|:.|.:|...
Frog   365 FIGLESLNKLTLFGNKIKSVAKRAFSGIESLEHLNLGENALRSVHSEAFGEMK-NLKELVVGSSS 428

  Fly   362 LHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVG 426
            ..|||.|:|:.:|:.:..||...:..    |..|....:...:|:.|....|.|:.
Frog   429 FLCDCHLKWLPQWLTSRRLQTKVKAS----CAHPGSLNNTSIFSVPPRSFVCDDLP--------- 480

  Fly   427 LADNLKPTLPSSPDSVEYETGTGTG-TVGTGTAASAPVT---------------SSVSSSTSTTT 475
                 ||.:...|::.....|.... |....:::.:|:|               .:.:|.|....
Frog   481 -----KPQIRVQPETTMAVLGKAIRFTCSAASSSPSPMTFAWKKDNEILHNAEVENFASGTEREG 540

  Fly   476 PTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITTSSSSSSSSST 540
            ..|..||.    ...|:.|.........|......|:.:.....|..|..:.|.|...|:..:.|
Frog   541 EVTEYTTI----LHLRNLTFAHEGRYQCIITNDFGPSYSSKARLTVNVLPSFIKTPRDSTIRAGT 601

  Fly   541 -------STGH---------GNGKQAPGWRQ----------------------GV---TNGNGNS 564
                   :.||         ..|...|..|:                      ||   |..|...
Frog   602 RARLECAADGHPTPEIAWQKDGGTDFPAARERRMHVMPDDDVFFIMDVKIEDMGVYSCTAQNSAG 666

  Fly   565 GVGGAGGLHKPQRPPLV--------------------LGYPPQRGTRI--DDANEVQVKHAFRQD 607
            .|.....|...:.|.||                    .|.||.|.|.:  |:...:..:|.:...
Frog   667 SVSANATLTVLEMPFLVHPLEDRVVSTGATLALQCKASGSPPPRITWLKGDEPLVMTERHHYTPG 731

  Fly   608 SSVII----------QWDSDTANILGFRVVYR---------LFGEKAFKQGPPLESSEREFKIKN 653
            :.::|          ::..:.:|.||....|.         ..|||...:|      ...|.|..
Frog   732 NQLLIIRQVMSEDAGKYTCEMSNTLGTERAYSHVSIASTAGCQGEKDKMEG------MMTFGIIT 790

  Fly   654 VPAQECII-------VCVI-------------SLEELHVTPETVPYQQ----CREVRTV------ 688
            : |..|.|       ||:|             :.:|..|.|:...|..    |....:|
Frog   791 I-AVVCSIVLTSLVWVCIIYQTRKKSEVYSVTNTDETIVPPDVPSYLSSQGLCSSDGSVNPEAEA 854

  Fly   689 ASQASNMDKITIAASAAICGT 709
            .|.|....::...:|...|.|
Frog   855 CSVAYRQPRLCTCSSGEACKT 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	60/222 (27%)
		leucine-rich repeat	86..105	CDD:275380	2/19 (11%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	20/57 (35%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..202	CDD:275380	11/23 (48%)
		leucine-rich repeat	203..225	CDD:275380	6/22 (27%)
		leucine-rich repeat	226..253	CDD:275380	11/46 (24%)
		LRR_8	254..337	CDD:338972	29/85 (34%)
		leucine-rich repeat	254..302	CDD:275380	19/50 (38%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		PCC	332..>413	CDD:188093	22/80 (28%)
		PRK10927	<1061..>1097	CDD:236797
lrig1	XP_002938412.1	LRRNT	28..59	CDD:214470	4/5 (80%)
		leucine-rich repeat	57..80	CDD:275378	6/22 (27%)
		PLN00113	<58..>370	CDD:215061	91/324 (28%)
		leucine-rich repeat	104..127	CDD:275380	5/29 (17%)
		leucine-rich repeat	128..151	CDD:275380	5/25 (20%)
		leucine-rich repeat	152..199	CDD:275380	13/47 (28%)
		leucine-rich repeat	200..223	CDD:275380	8/22 (36%)
		leucine-rich repeat	224..247	CDD:275380	11/22 (50%)
		leucine-rich repeat	248..295	CDD:275380	15/46 (33%)
		leucine-rich repeat	272..292	CDD:275380	8/19 (42%)
		leucine-rich repeat	296..319	CDD:275380	3/22 (14%)
		leucine-rich repeat	320..343	CDD:275380	10/23 (43%)
		LRR_8	343..405	CDD:338972	18/61 (30%)
		leucine-rich repeat	344..370	CDD:275380	8/25 (32%)
		leucine-rich repeat	371..394	CDD:275380	7/22 (32%)
		leucine-rich repeat	395..413	CDD:275380	6/17 (35%)
		LRRCT	429..477	CDD:214507	12/51 (24%)
		leucine-rich repeat	445..471	CDD:275380	5/29 (17%)
		IG	488..582	CDD:214652	14/97 (14%)
		Ig_1	603..677	CDD:143240	11/73 (15%)
		I-set	680..759	CDD:369462	14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910