DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and LOC100485358

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_002943096.1	Gene:	LOC100485358 / 100485358	-ID:	-	Length:	837	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	88/409 - (21%)
Similarity:	145/409 - (35%)	Gaps:	106/409 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 ELSVQCDQVDFSQLLAAMNT----------HARLKPVDLLYVNNSTISELP----------DAVF 101
            |::...|.||....|.:::|          :..|..:.|..:..|:|.:|.          .|..
Frog   242 EITYYTDTVDIFSWLPSISTRELVFYRGKFNENLLWIMLENIQRSSILDLSLLSVDFSRSHSANK 306

  Fly   102 SNLSLHNLQLSSCGIQRIATGAFKGQESVLR------------NLNLQDNLLADVPVEALKVLGK 154
            :|:|:.:|:|.:..::.:.      ...:||            ||.:.:.....||.:|...:..
Frog   307 TNVSIDDLRLRTLRVKDVT------NPDILRFDWTFTWFRKISNLYIINVNFNSVPCDAWSEMSN 365

  Fly   155 LNLLDLSKNQLSHIPDDAF--------VGLTKLSTLKLNDNNVTLASNAFRGLEQSLKNLNLKGT 211
            |..||:|.::|.    |.:        |.|....|..|..||:           |||:.|:|...
Frog   366 LEKLDMSTDELV----DTYLYNPWCQDVALPTTDTFILAYNNL-----------QSLRMLSLLTA 415

  Fly   212 KQRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVR 276
            |..|          ||.|||..|.:     .....:.....::..:.|:.|::: :|  .|..:.
Frog   416 KWPK----------LATLDLRSNSL-----GSNDEMCTWTPSIRTVILKDNMLK-VG--VFQCLP 462

  Fly   277 KTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIG-FNLLTSLPEAAFRGN-----------PGITL 329
            .|:..|.|              |..:|..||:. ||..|:|.:.....|           |.:.:
Frog   463 TTVEFLDL--------------SHSQLEQLDMDYFNKATNLKQLILSHNKIKFISSEWKSPNLQV 513

  Fly   330 LALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGT 394
            |||:.|....:..|:|..| ..||.|:.|.....|.|.|......||.....|.:.......|.:
Frog   514 LALEDNSFGVINVGSFKDL-PKLRNLTAGDNPYGCTCDLYRFFSQIREEGRIVLADWPQAYKCYS 577

  Fly   395 PPRFRDRGFYSIQPEELSC 413
            ||...|.......|.::.|
Frog   578 PPDLLDTKVEFYNPGKVQC 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	48/234 (21%)
		leucine-rich repeat	86..105	CDD:275380	5/28 (18%)
		leucine-rich repeat	106..129	CDD:275380	2/22 (9%)
		LRR_8	131..189	CDD:338972	18/77 (23%)
		leucine-rich repeat	131..154	CDD:275380	7/34 (21%)
		leucine-rich repeat	155..178	CDD:275380	8/30 (27%)
		leucine-rich repeat	179..202	CDD:275380	4/22 (18%)
		leucine-rich repeat	203..225	CDD:275380	5/21 (24%)
		leucine-rich repeat	226..253	CDD:275380	6/26 (23%)
		LRR_8	254..337	CDD:338972	21/94 (22%)
		leucine-rich repeat	254..302	CDD:275380	8/47 (17%)
		leucine-rich repeat	303..326	CDD:275380	8/34 (24%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	20/80 (25%)
		PRK10927	<1061..>1097	CDD:236797
LOC100485358	XP_002943096.1	PRK15370	<39..>160	CDD:185268
		leucine-rich repeat	39..55	CDD:275380
		LRR_8	56..115	CDD:338972
		leucine-rich repeat	57..80	CDD:275378
		leucine-rich repeat	81..104	CDD:275378
		leucine-rich repeat	105..128	CDD:275378
		leucine-rich repeat	129..153	CDD:275378
		LRR	<340..>500	CDD:227223	46/206 (22%)
		leucine-rich repeat	345..365	CDD:275380	4/19 (21%)
		leucine-rich repeat	366..419	CDD:275380	18/67 (27%)
		leucine-rich repeat	420..442	CDD:275380	6/26 (23%)
		leucine-rich repeat	443..464	CDD:275378	4/23 (17%)
		leucine-rich repeat	465..488	CDD:275378	8/36 (22%)
		LRR_8	488..544	CDD:338972	14/56 (25%)
		leucine-rich repeat	489..510	CDD:275378	2/20 (10%)
		leucine-rich repeat	511..534	CDD:275378	7/23 (30%)
		PCC	516..>581	CDD:188093	18/65 (28%)
		TIR	653..791	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910