DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and igsf10

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_009289666.1	Gene:	igsf10 / 100329456	ZFINID:	ZDB-GENE-130530-827	Length:	2497	Species:	Danio rerio

Alignment Length:	1538	Identity:	281/1538 - (18%)
Similarity:	471/1538 - (30%)	Gaps:	549/1538 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PAATTPLL---LLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLA 72
            |||.:.||   ::|..:|..|....:.||         .||:|                    .|
Zfish     4 PAADSRLLWRFMVLLCVLACLTHRSSGCP---------KSCVC--------------------YA 39

  Fly    73 AMNTHARLKPVDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQ 137
            ....|...:          .:||:|..:                           ::.:..:||.
Zfish    40 PSEVHCTFR----------YLSEMPGDI---------------------------QTAVERINLG 67

  Fly   138 DNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASNAFRGLEQS 202
            .|.|:.:...||..|.||.||.|..|.:..:.|.||.|||.|..||::.|.|
Zfish    68 YNSLSSLQANALSGLNKLELLMLHSNMIKTVEDSAFSGLTSLQVLKMSYNRV------------- 119

  Fly   203 LKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKEL-PGAGGIRVFDGLDALTALNLERNLIQS 266
             :.||         .::.|||.:|..|.|..|.|..: |.:     |.||..|..:|||.|.:|.
Zfish   120 -EKLN---------KDTFRGLDNLVRLQLDHNLITFIHPES-----FYGLKRLQLINLEGNQLQQ 169

  Fly   267 IGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLA 331
            :....|..||                 .|.:.....|:.:.:..|.|.:||.|...|...|..|.
Zfish   170 LHPDTFISVR-----------------FGQILKWSSLKTIYLSDNALGTLPAAVLSGCVKIENLF 217

  Fly   332 LDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRN--GDLQVTSRERNPQF--- 391
            |.|||.|                         |||::.|:|:||..  |.|:.   :|:.:|
Zfish   218 LSGNPWS-------------------------CDCRMSWLAKWIEKHPGVLKC---KRDKKFLKE 254

  Fly   392 ----CGTPPRFRDRGFYSIQPEELSC---------------------PDIADAALRGPVG-LADN 430
                |..|...|......:|.:..:|                     .:::......|:| |..|
Zfish   255 PCPICEFPLSSRGSSIVQLQSDGYTCSRPQIKPYLKLRNFTMTDGDYTEVSPVDFVAPIGSLEMN 319

  Fly   431 LKP------------TLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSV---------------- 467
            :|.            ..|||.:::....|.....|   ||..|.|::.:
Zfish   320 IKDQSHSDARVACLVQRPSSMENMSAIFGLDGKDV---TALRATVSTLLVCNIDYDDIREIWDIL 381

  Fly   468 ---------------SSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTASPASNPP- 516
                           .|..|....|.....:|||...        |:....|.|.       |.
Zfish   382 ATYSDFPMILERELAISLQSDAVYTYKQAVSTAEDVF--------TEIEAKIKAI-------PEW 431

  Fly   517 -VNGTGTVQATSITTSSSSSSSSSTST------GHGNGKQAPGW----RQGVTNGNGNSGVGGAG 570
             :.|...:|....||:..:.:....||      |..|.:....|    |...|.......|||..
Zfish   432 LMQGRVMLQLDRATTAFPTLTIKYLSTIQIDVGGSKNNRDEYSWTMIRRDNQTRTEHLLLVGGMT 496

  Fly   571 GLH-----KPQRPPLVLGYPPQRGTRIDDANEVQVKHAFRQDSSVIIQWD----------SDT-- 618
            .|:     .|:  |::....|       |.::::..:. .:|..::|..:          |||
Zfish   497 ELNCQTFGNPK--PIIEWILP-------DGSKIRAPYN-SEDQRIVITHEGILSVKSAEISDTGV 551

  Fly   619 ----------ANILGFRVVYRLFGEKAFKQGPPLESSERE---FKIKNVPAQECIIVCVISLEEL 670
                      |::|.|||...           ||:..|.|   .::.:...|...:.|. ||.
Zfish   552 YHCIATSYLDADVLAFRVTVM-----------PLDIEEEEINGIRVSHHLGQNLRLDCT-SLS-- 602

  Fly   671 HVTPETVPYQQCREVRTVASQASNMDKITIAASAAICGTIIVAVIVF--------IAASRRSRKL 727
              :|:.       .::.:....:.:||.....:....||:::..:.:        :|.:.....|
Zfish   603 --SPQA-------SIQWILPDHTVLDKSYGKRTLHRNGTLVIHGLTYRDIGFYRCLAGNFLGADL 658

  Fly   728 QSSQQKSPLPIGGLPVNCCGPT-------------GSPGPLGSIATLSAFNNHKEWDQVSAYSGR 779
            .:||    :.|....||...||             .:...|||          :...|.::...|
Zfish   659 LASQ----VTIYDDWVNSTMPTHVKESNHRVVQIIDNSQTLGS----------RYLSQRTSEESR 709

  Fly   780 SIPRPRIYPVEQPDDMRSHFSGMP-GKVGKSRSLADGQSQHSFSNNSHRGYLGSAFPSNLVNSRP 843
            ||...|.|..     ::|.|..:| |:.|..|:     |:..|:....:.      ...|:| :|
Zfish   710 SITSDRPYTW-----LQSRFHKVPIGRRGNGRN-----SRRVFNKRFQKE------GKTLIN-KP 757

  Fly   844 ELRQSRQSLAAASERMSRASYAGSIHGGNGGGGGLGGNGGGGGNGLPVSSLMAMS---------- 898
            ::::..:.....|:.:.:..              ...|....|:|:.....:.:|
Zfish   758 QIKEINKEAVNLSKTLFKEQ--------------SDDNNAASGDGINEDEFIVISTTKTLEKKQV 808

  Fly   899 GMVGGGGPAS----------IASSARRSRPRSRSREQLNTTHIHNHRPGSRYSQAGSTHTLNNY- 952
            ..:....|.:          :.|.......|::.:..|.|....:..|.|..:   .::||:||
Zfish   809 SSINTEIPRTYKTVNSAFIQVTSDDTSHVLRTKKKSNLVTGITDSQTPTSPIT---PSYTLSNYG 870

  Fly   953 ------------CDTSDNWTDHDMDIY--MARNP-----TTRNGLVPLXGRLTLSXYFNVV---- 994
                        .|...|.||.:..:|  ....|     |.:..|:.:  .||.| ....|
Zfish   871 TQRNYKKQSKTKSDYKLNQTDGETSLYDTATSRPSETLVTHKPSLIEVT-ELTFSGDSEDVTSGT 934

  Fly   995 --LNWDGIFXQYLTPTIEGTEGRGR------GRRQQQQQQQQQQQQQQQHQQL-------QHQQQ 1044
              .|:.|       |.:...|.:.:      ...:.|::...|..|:.:.:.|       :||.|
Zfish   935 TQYNFQG-------PNVTNVEPKSQTIFTAVTTTEDQEKITFQTTQRIKSELLPGSTIISKHQIQ 992

  Fly  1045 QQHQHQLQQLRNERHQQRHR-------NDQQW-----------EQPYQPAQQQHQRLQYYMP--- 1088
            .....::|..:..:...|.|       :|.|.           ::...|..:...:....:.
Zfish   993 IVPSRKMQPGKKRKFNGRRRIIRPSKISDIQSILDKFKLHSTNKEDNLPISETTDKFAECVKMKS 1057

  Fly  1089 -----QTERCTSPPDVVPRAANFHNSNTTSTGHNDNSNSHGSSSSSSSNIAQQQQAPL-AAMTAA 1147
                 .|::|....|..|       .|:|...|         .:.||.::|:|   |: |...|.
Zfish  1058 DKSGVSTDKCRISVDQSP-------INSTDMYH---------ITISSLSVAEQ---PVRAGSRAT 1103

  Fly  1148 LGDATAAATAAAAAAASASGIVVENYFNEYERQEIIYHHPTSRRSSSSSSSCSAAATRHVPRSNA 1212
            :.|:..:.|...:.:..:.|  .:.|||..|:                  :.:|..|.....|:.
Zfish  1104 VTDSQMSTTLVHSISEESGG--YKKYFNSKEK------------------AFTATTTSTTTMSSQ 1148

  Fly  1213 FRLQLPAVATATTNNILYNISNKHGATGHNGSIGNYKAHTFSDSCNCTCNCSLSEEEEISQETAA 1277
            |          |...||:     .|:..:||.......::.:.|.|.....|.|..|.....|..
Zfish  1149 F----------TQGKILW-----QGSFENNGETPRKHQNSITLSTNKEQMTSTSTAEPYKSTTPL 1198

  Fly  1278 VTAA---------------------AGEDGDQAGSSLSSTSVS 1299
            .|..                     |..|.....|||:.|..|
Zfish  1199 PTTELHLTHVNVSPTKTKESNNTPDASSDDSSGSSSLTETDFS 1241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	42/200 (21%)
		leucine-rich repeat	86..105	CDD:275380	3/18 (17%)
		leucine-rich repeat	106..129	CDD:275380	0/22 (0%)
		LRR_8	131..189	CDD:338972	23/57 (40%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		leucine-rich repeat	203..225	CDD:275380	5/21 (24%)
		leucine-rich repeat	226..253	CDD:275380	9/27 (33%)
		LRR_8	254..337	CDD:338972	22/82 (27%)
		leucine-rich repeat	254..302	CDD:275380	10/47 (21%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	20/89 (22%)
		PRK10927	<1061..>1097	CDD:236797	7/61 (11%)
igsf10	XP_009289666.1	LRR_8	61..119	CDD:290566	23/57 (40%)
		leucine-rich repeat	61..84	CDD:275380	7/22 (32%)
		leucine-rich repeat	85..108	CDD:275380	10/22 (45%)
		LRR_8	107..167	CDD:290566	25/87 (29%)
		leucine-rich repeat	109..132	CDD:275380	10/45 (22%)
		leucine-rich repeat	133..156	CDD:275380	9/27 (33%)
		leucine-rich repeat	157..188	CDD:275380	10/47 (21%)
		leucine-rich repeat	189..212	CDD:275380	7/22 (32%)
		TPKR_C2	221..>238	CDD:301599	10/41 (24%)
		Ig	490..557	CDD:299845	13/76 (17%)
		IG_like	492..571	CDD:214653	18/88 (20%)
		IG_like	590..652	CDD:214653	10/73 (14%)
		Ig	594..655	CDD:143165	9/72 (13%)
		IG_like	1529..1612	CDD:214653
		Ig	1538..1611	CDD:299845
		I-set	1621..1709	CDD:254352
		Ig	1632..1709	CDD:299845
		IG_like	1724..1806	CDD:214653
		Ig	1729..1806	CDD:299845
		I-set	1813..1898	CDD:254352
		Ig	1833..1905	CDD:299845
		I-set	1918..2009	CDD:254352
		Ig	1928..2009	CDD:299845
		IG	2022..2101	CDD:214652
		IGc2	2028..2093	CDD:197706
		I-set	2118..2203	CDD:254352
		Ig	2134..2203	CDD:299845
		IG_like	2218..2303	CDD:214653
		IGc2	2225..2293	CDD:197706
		I-set	2307..2397	CDD:254352
		Ig	<2337..2397	CDD:299845
		IG_like	2409..2496	CDD:214653
		Ig	2420..2493	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100