DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and lrig3

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_002940426.3	Gene:	lrig3 / 100151727	XenbaseID:	XB-GENE-1219309	Length:	1109	Species:	Xenopus tropicalis

Alignment Length:	1058	Identity:	198/1058 - (18%)
Similarity:	351/1058 - (33%)	Gaps:	378/1058 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLLLPLILG------RLHVAHAQCPWQRDVPDLQTSCICAYNL----GRELSV-------QCDQ 64
            |||:.||:||      |:......||         :.|.|..:|    .|:|:|       ...|
Frog    17 LLLITPLVLGFHGLERRVRRDRGPCP---------SPCRCLGDLLDCSRRKLAVVPANLPEWVVQ 72

  Fly    65 VDFS-QLLAAMNTHA--RLKPVDLLYVNNSTISELPD--AVFSNLSLHNLQLSSCGIQRIATGAF 124
            :|.| ..|:::|..:  .|..:..|.:||:.:..:||  .:.:|::|
Frog    73 LDLSHNKLSSINPSSMNHLHNLRELRLNNNELQIVPDLGPLSANITL------------------ 119

  Fly   125 KGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNV 189
                     .:|.:|.:..:..|.||....|..||||.|.::.:...:|..| :|..|.:|:|.:
Frog   120 ---------FSLTNNKIEVILPEHLKPYQSLETLDLSNNLITELRAGSFPTL-QLKYLYINNNRI 174

  Fly   190 -TLASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDA 253
             |:.|.||..|..:|:.|.|...:...:|..:..|.:|..|:|::|.|||:.|.    .|.|||:
Frog   175 STMQSGAFDNLSATLQVLKLNKNRISYIPSKMFKLSNLQHLELNRNRIKEILGL----TFQGLDS 235

  Fly   254 LTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSL------------------ 300
            |.:|.::||||..:.:.||.|: .|:..|.|.:|.|.|...|.::.|
Frog   236 LKSLRIQRNLITRLMDGAFWGL-STMEILQLDHNRLTEITKGWLYGLLMLQKLHLSQNAISSITP 299

  Fly   301 ------KELRVLDIGFNLLTSLPEAAFR----------GNPGITLLA------------------ 331
                  ::|..||:.||.||.|.|::|.          ||..|..:|
Frog   300 DAWEFCQKLSELDLAFNQLTRLEESSFAGLGLLGGLYIGNNKINFIADGAFRGLSSLNSLDLKSN 364

  Fly   332 -----------------------LDGNPLSSVPEGAFAHLNA----------------------- 350
                                   |..|.::|:.:.||:.|:|
Frog   365 EISWTIEDMNGTFSGLERLKRLILQDNRITSITKKAFSWLDALEYLDLSDNAITSMQTNAFSQMK 429

  Fly   351 TLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPD 415
            :|:.|.|....|.|||:|:|:.:|:.....|......    ||.|...:.:..:::.|::..|.|
Frog   430 SLQQLYLNTTSLLCDCQLKWLPKWLAESKFQTFVNAS----CGHPQILKGKSIFAVSPDDFVCDD 490

  Fly   416 IADAALRGPVGLADNLKPTLPSSPDSVEYETGTG-TGTVGTGTAASAPVTSS------------- 466
            ..              ||.:...|::.....|:. |......:::.:|:|.:
Frog   491 FP--------------KPQITVQPETQSAIKGSNVTFICSAASSSESPMTFAWKKDNELLHDSEI 541

  Fly   467 ------------------------------------VSSSTSTTTPTTTTTTTTAEP-------- 487
                                                :|:....|.......|....|
Frog   542 ENYAHLRAQGGEVMEYTTILRLRNVEFINEGKYQCVISNHFGPTYSVKAKLTVNMLPLFTKMPMD 606

  Fly   488 -TTRRSTT---------RPPTKSTTTISATTASPAS-----------------NPPVNGTGTVQA 525
             |.|..:|         .|..:.....:..|..||:                 |......|....
Frog   607 LTIRAGSTARLECAAVGHPTPQIAWQKNGGTDFPAARERRMHVMPEDDVFFIVNVKTEDIGVYSC 671

  Fly   526 TSITTSSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGG-----AGGLHKPQRPPLVLGYP 585
            |:..::.|.|::::.:.     .:.|.:.:.:.:...:.|...     |||...|:
Frog   672 TAQNSAGSISANATLTV-----LETPSFLRPLVDRTASKGETTVLQCIAGGSPTPK--------- 722

  Fly   586 PQRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFK 650
             ...|:.|....|..:|.|...:..:|..|:|
Frog   723 -VNWTKDDSPLVVTERHFFAAGNQHLIIVDTD--------------------------------- 753

  Fly   651 IKNVPAQECIIVCVISLEELHVTPETVPYQQC-REVRTVASQASNMDK------ITIAASAAICG 708
            :::.....|.:..::..|..::....:|...| ..|.|:  |.:..|.      :.||....:.|
Frog   754 LEDAGKYTCEVSNILGTERGNIHLSVLPNPTCDSPVNTI--QTAEDDGWATAGIVIIAVVCCVVG 816

  Fly   709 TIIVAVIVFIAASRRSRKLQ-SSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLS-------AFN 765
            |.:|.|::.....|::.... ::..::.||:           .:|..|.|..||:       :..
Frog   817 TSLVWVVIIYHTRRKNEDCSVTNTDETNLPV-----------DTPSYLSSQGTLAERQDGYGSSE 870

  Fly   766 NHKEWDQVSAYSGRSIPRPRIYPVEQPDDMRSH-------------------FSGMPGKVGKSRS 811
            |.......|:.||        |.::|.|:...|                   ::|:||.:....:
Frog   871 NGSHQFITSSMSG--------YFLQQRDNGACHLDNGSEADMEVATDPLLFNYTGVPGSLYLRGN 927

  Fly   812 LADGQSQHSFSNNSHRGY 829
            ..|..:...|    |.||
Frog   928 TYDPDAYEIF----HAGY 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	54/216 (25%)
		leucine-rich repeat	86..105	CDD:275380	6/20 (30%)
		leucine-rich repeat	106..129	CDD:275380	1/22 (5%)
		LRR_8	131..189	CDD:338972	17/57 (30%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..202	CDD:275380	9/23 (39%)
		leucine-rich repeat	203..225	CDD:275380	5/21 (24%)
		leucine-rich repeat	226..253	CDD:275380	11/26 (42%)
		LRR_8	254..337	CDD:338972	33/157 (21%)
		leucine-rich repeat	254..302	CDD:275380	17/71 (24%)
		leucine-rich repeat	303..326	CDD:275380	12/32 (38%)
		leucine-rich repeat	327..350	CDD:275380	8/63 (13%)
		PCC	332..>413	CDD:188093	22/103 (21%)
		PRK10927	<1061..>1097	CDD:236797
lrig3	XP_002940426.3	LRRNT	40..67	CDD:214470	8/35 (23%)
		leucine-rich repeat	52..69	CDD:275380	3/16 (19%)
		LRR	<58..>243	CDD:227223	56/216 (26%)
		internalin_A	70..>437	CDD:380193	92/399 (23%)
		leucine-rich repeat	73..93	CDD:275380	5/19 (26%)
		leucine-rich repeat	94..140	CDD:275380	12/72 (17%)
		leucine-rich repeat	141..163	CDD:275380	8/22 (36%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		leucine-rich repeat	189..211	CDD:275380	5/21 (24%)
		leucine-rich repeat	212..235	CDD:275380	11/26 (42%)
		leucine-rich repeat	236..259	CDD:275380	9/23 (39%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		leucine-rich repeat	284..307	CDD:275380	0/22 (0%)
		leucine-rich repeat	308..331	CDD:275380	10/22 (45%)
		leucine-rich repeat	332..355	CDD:275380	4/22 (18%)
		leucine-rich repeat	356..380	CDD:275380	0/23 (0%)
		leucine-rich repeat	383..406	CDD:275380	6/22 (27%)
		leucine-rich repeat	407..428	CDD:275380	0/20 (0%)
		PCC	411..>489	CDD:188093	15/81 (19%)
		Ig_3	493..580	CDD:404760	7/86 (8%)
		Ig strand A	494..497	CDD:409353	1/2 (50%)
		Ig strand A'	500..505	CDD:409353	1/4 (25%)
		Ig strand B	511..519	CDD:409353	1/7 (14%)
		Ig strand C	526..531	CDD:409353	1/4 (25%)
		Ig strand C'	533..535	CDD:409353	0/1 (0%)
		Ig strand D	552..555	CDD:409353	0/2 (0%)
		Ig strand E	559..565	CDD:409353	0/5 (0%)
		Ig strand F	572..579	CDD:409353	0/6 (0%)
		Ig strand G	586..594	CDD:409353	0/7 (0%)
		IgI_LRIG1-like	600..689	CDD:409420	12/93 (13%)
		Ig strand B	615..619	CDD:409420	0/3 (0%)
		Ig strand C	628..632	CDD:409420	0/3 (0%)
		Ig strand E	654..658	CDD:409420	0/3 (0%)
		Ig strand F	668..673	CDD:409420	0/4 (0%)
		Ig strand G	681..684	CDD:409420	1/2 (50%)
		I-set	692..779	CDD:400151	16/129 (12%)
		Ig strand A	693..695	CDD:409353	0/1 (0%)
		Ig strand A'	700..704	CDD:409353	0/3 (0%)
		Ig strand B	707..714	CDD:409353	0/6 (0%)
		Ig strand C	721..727	CDD:409353	1/15 (7%)
		Ig strand C'	728..730	CDD:409353	0/1 (0%)
		Ig strand D	737..740	CDD:409353	1/2 (50%)
		Ig strand E	743..751	CDD:409353	1/7 (14%)
		Ig strand F	758..766	CDD:409353	1/7 (14%)
		Ig strand G	770..779	CDD:409353	1/8 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910