DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and vasnb

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001104232.1	Gene:	vasnb / 100004428	ZFINID:	ZDB-GENE-110714-1	Length:	668	Species:	Danio rerio

Alignment Length:	799	Identity:	192/799 - (24%)
Similarity:	278/799 - (34%)	Gaps:	220/799 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLLPLILGRLHVAHAQCPWQRDV-PDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLKP 82
            |.||::|..|.......|...|. ||   :|.|..    :.|:.|    ||:....|.
Zfish     3 LFLPVLLPLLFYQLVPSPVLADTCPD---NCTCQV----QDSIFC----FSRKDTKMP------- 49

  Fly    83 VDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVE 147
                       ||:|..|      .||.:...||:.::...|....| |..|:|..|.|.::|..
Zfish    50 -----------SEVPTTV------KNLYVFKNGIESLSQEDFVHLGS-LEMLDLSQNQLTELPDH 96

  Fly   148 ALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNV-TLASNAFRGLEQSLKNLNLKGT 211
            ..:.|..||.||||.||:.||...:|.||..|..|.|..|.: ::...||.||.:.|: |.|:|.
Zfish    97 VFEPLSSLNNLDLSANQIVHISKYSFAGLELLERLYLYSNLIESIHPAAFDGLHELLE-LKLQGN 160

  Fly   212 KQRKVPESIRGLK--SLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAG 274
            |.:.:|    .||  .|..|||..|.|.. ||.         :.|....||...:..:|
Zfish   161 KLKILP----ALKMPHLLLLDLRFNSIPS-PGP---------NDLQTPKLESLKLGGLG------ 205

  Fly   275 VRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNP--- 336
                   ||.||..|       :.|.|.|..|||..|.||:.| ...|...|:..|.|.|||
Zfish   206 -------LSTLNEEL-------LGSFKNLHELDISNNQLTAFP-VVLREAKGLVSLVLAGNPMGP 255

  Fly   337 ---------------------LSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDL 380
                                 |..:|| ..|.|...|:.|::.....:|.|.|.|...|:|...:
Zfish   256 LNWEDFEKLTELHELDISNLSLQGLPE-TLAQLLPHLKRLTVAENPFNCLCNLAWFPSWLRTKQI 319

  Fly   381 QVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYE 445
            |:...|...  |..||....:....:...|..||.
Zfish   320 QLGRTEETR--CHFPPLNSGKVLERLGHREFGCPI------------------------------ 352

  Fly   446 TGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRST-----TRPPTKSTTTIS 505
                |.|:.|....|    ::|..:..|:.|:||......:|:...||     ..|||.||:...
Zfish   353 ----TTTITTRMVKS----TAVPPAPFTSVPSTTHAILPPKPSNNPSTDIDYDPAPPTPSTSIDP 409

  Fly   506 --ATTASPASNPPVNGTGTVQATSITTSSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGG 568
              .:|..| ||..:|| ||...              .:.||......|               |.
Zfish   410 DLRSTFCP-SNICLNG-GTCWL--------------DNEGHVECICVP---------------GT 443

  Fly   569 AGGLHKPQRPPLVLGYPPQRGTRIDDANEVQVKHAFRQDSSV---IIQWDSDTANILGFRVVYR- 629
            :|...:.:..||:  :|    |.|....|:..|..  ..||:   :.::.....||.|.::.||
Zfish   444 SGTYCEKEEDPLL--FP----TEITSEPEIIAKKV--TSSSIHLDLRRYIDMRPNIRGVKLTYRN 500

  Fly   630 LFGEKAFKQGPPLESSEREFKIKNVPAQECIIVCVISLEEL-HVTPETVPYQQCREVRTVASQA- 692
            |.|:....:...:.....|:.::.:.......||...|.|. :|.      :.|.|.:||:.|.
Zfish   501 LSGQDKRPKQLSVPHYYDEYILRGLQPNSTYSVCASPLGEAGNVN------RVCTEAQTVSLQIP 559

  Fly   693 --------SNMDKITIAASAAICGTIIVAVIVFIAASRRSRKLQ---------SSQQKSPLPIGG 740
                    ..:..:.|.|.|.:...::|||.|.:|.....:|.:         |..:...|..|.
Zfish   560 PTGARLEDPKLTTMLIPALAILLLLVLVAVAVGVACYMHKKKSKGHLDLECDPSQLELEGLDNGA 624

  Fly   741 LP----VNCCGPTGSPGPL 755
            ||    :..|..|...|.|
Zfish   625 LPQKKEIIACPSTVQNGGL 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	59/202 (29%)
		leucine-rich repeat	86..105	CDD:275380	4/18 (22%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		LRR_8	131..189	CDD:338972	24/57 (42%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	13/22 (59%)
		leucine-rich repeat	179..202	CDD:275380	8/23 (35%)
		leucine-rich repeat	203..225	CDD:275380	8/23 (35%)
		leucine-rich repeat	226..253	CDD:275380	8/26 (31%)
		LRR_8	254..337	CDD:338972	26/106 (25%)
		leucine-rich repeat	254..302	CDD:275380	10/47 (21%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	10/46 (22%)
		PCC	332..>413	CDD:188093	23/104 (22%)
		PRK10927	<1061..>1097	CDD:236797
vasnb	NP_001104232.1	LRR_RI	<51..181	CDD:238064	49/141 (35%)
		LRR_8	54..114	CDD:290566	21/66 (32%)
		leucine-rich repeat	56..79	CDD:275380	6/28 (21%)
		LRR_4	79..118	CDD:289563	17/39 (44%)
		leucine-rich repeat	80..103	CDD:275380	7/22 (32%)
		leucine-rich repeat	104..151	CDD:275380	21/46 (46%)
		leucine-rich repeat	152..172	CDD:275380	8/24 (33%)
		leucine-rich repeat	173..195	CDD:275380	9/31 (29%)
		leucine-rich repeat	196..219	CDD:275380	9/42 (21%)
		leucine-rich repeat	220..242	CDD:275380	9/22 (41%)
		leucine-rich repeat	243..266	CDD:275380	5/22 (23%)
		leucine-rich repeat	267..290	CDD:275380	5/23 (22%)
		LRRCT	299..351	CDD:214507	12/53 (23%)
		EGF_CA	417..449	CDD:238011	12/62 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000