Protein Alignment CG31935 and RAB3GAP1

DIOPT Version :9

• Sequence 1: NP_608608.2
• Gene: CG31935 / 33338
• FlyBaseID: FBgn0051935
• Length: 916
• Species: Drosophila melanogaster
• Sequence 2: XP_011509125.1
• Gene: RAB3GAP1 / 22930
• HGNCID: 17063
• Length: 1024
• Species: Homo sapiens
• Alignment Length: 1039
• Identity: 310/1039 - (29%)
• Similarity: 480/1039 - (46%)
• Gaps: 211/1039 - (20%)

  Fly     4 EIDDNEFYRENFSADSDWEVFNAQLGEILQKWDVSSDSETRNLKSEEIFSCNWKVEREKLDMLRN 68
            |.:...|...:|:..|:||.|.:::.|:|..|.:..:|..:.|:.....|..|:.:.:::.....
Human     6 EPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKGIFTSGTWEEKSDEISFADF 70

  Fly    69 GIEVEYHQAILE--DEELVRAEAKEITCLQRTSCHHDLMSTGNSFGPPIRSSQELHILARIYGLR 131
            ...|.:|..:.|  |:| .:.|..|....|..   .||:...|.|.|      ..|.|.|.||||
Human    71 KFSVTHHYLVQESTDKE-GKDELLEDVVPQSM---QDLLGMNNDFPP------RAHCLVRWYGLR 125

  Fly   132 RFIVLHPVNPTLNYMRSTSEFNFFLSAVAVVSAEVQSLVPIFVQIYDPKW-NYYTGVALAPALRT 195
            .|:|:.|...: :.:.|.|:.|..||:|::........||:||||:. || ..|.|....|.:||
Human   126 EFVVIAPAAHS-DAVLSESKCNLLLSSVSIALGNTGCQVPLFVQIHH-KWRRMYVGECQGPGVRT 188

  Fly   196 NFRLIGLEKAPPECRFLMGLLTLFREKVPTSYTQAAMISVCT--TYAL-DTMRIRMPMYVPFDHG 257
            :|.::.|.|.|.:...|.|||.:|:.|:....|....:|:..  ||.| |..:...|...|
Human   189 DFEMVHLRKVPNQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRFTYVLQDWQQYFWPQQPP---- 249

  Fly   258 LSSEDIVVDGEVSHLEVQQFCALPHGYKPESRTEIYLVYTWPELSEHVAFDSEQRSDFVPAKAPL 322
              ..|.:|.|||..||   |..||.|...:..:|::|..|||.|:|.:..|::..||..|.:||.
Human   250 --DIDALVGGEVGGLE---FGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDPIQAPH 309

  Fly   323 GKIYLSVEASSYLSCCLRDYQS----VAEVTRSLESFVGRNFSGTSSGAEAA--SNPLDRITE-- 379
            ..:  .|..:....|.|.|:.:    :.....|.:..:||: :....|.|.|  ::.|.::||
Human   310 WSV--RVRKAENPQCLLGDFVTEFFKICRRKESTDEILGRS-AFEEEGKETADITHALSKLTEPA 371

  Fly   380 ----HKLTK-----------RRERSFELPSQAGLTKRLPGPMTESELSELLAYLFPDMHPEMALF 429
                |||:.           |:.|..|           ..|:....|:.:|.:||||...|.
Human   372 SVPIHKLSVSNMVHTAKKKIRKHRGVE-----------ESPLNNDVLNTILLFLFPDAVSEK--- 422

  Fly   430 PYAKKNFTDKFDP----------MRIKSAVPDSLVCRLSCLLATCHAHLGSVEGMAQVWAAFTRQ 484
            |......||..:|          .:.|||..|||..:|:..|...:.:.|.::|:|.:|..|..:
Human   423 PLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLE 487

  Fly   485 LRLLWDNSLMVPGISAGFPDTRTCLLHQKLQMLNVCVERRVQREANSKRKSE-------GMVGKA 542
            :|..|:|:.::||:::|.||.|.|||||||||||.|:||:..|:...|..:.       |..|||
Human   488 MRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASDVTNIYPGDAGKA 552

  Fly   543 SSE------EEEDED------------DDEGEFFDC----DDLTAGA------GSPTKAVLSLKP 579
            ..:      :|.|::            |.|.|||:|    ::|....      |.| |.:.:|:|
Human   553 GDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEELKGNGQESGKKGGP-KEMANLRP 616

  Fly   580 EGRLRRLNNERLLEEPDEYLYIPDTQEPVPKTEDQLQDDAEVMLKLG---PGSGLTTQMMCTSLL 641
            ||||.:.....||.. .|.||||.||||.|.|||.|::.:||:.|||   .|:.|..:|....||
Human   617 EGRLYQHGKLTLLHN-GEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLL 680

  Fly   642 SDMEAFKAANPRGIMEDFIRWYSPKDW--EEVTDELGQV--KHQLSIRMTTEGNTWQKVWEQAQA 702
            ||||:||||||...:|||:|||||:|:  |||.||.|.|  |.:||.||....|.|.:.||.|:.
Human   681 SDMESFKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVVLKGELSARMKIPSNMWVEAWETAKP 745

  Fly   703 VPVSRQKRLFDDTNEALKVLHYLETRKMHEIYNLTVIPLLHSAILKLADILSNAELEDLFSSQIE 767
            :|..||:||||||.||.||||||..:|..::....:..::|:|:||:.:   ...||::  |.::
Human   746 IPARRQRRLFDDTREAEKVLHYLAIQKPADLARHLLPCVIHAAVLKVKE---EESLENI--SSVK 805

  Fly   768 KLLSDLCRLSRSHSD------------------ELPSIKPLLDDLAELERRFYQFKCFERLSGYP 814
            |::..:.    |||.                  ::.:::.|:.....|:.:|...||.:.    .
Human   806 KIIKQII----SHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQE----E 862

  Fly   815 KRSSLQQ---VKLQFEEILRNDNCCTIVNRRLTAAGDG----TLYDILI----------PKLE-- 860
            ::..|::   ..|:..|:|            :|.||.|    .::.:.:          |:.|
Human   863 EKEDLERFVSCLLEQPEVL------------VTGAGRGHAGRIIHKLFVNAQRAAAMTPPEEELK 915

  Fly   861 -----EDMADRLIS-------KDYIIRLDGDTKTT-------EKGLYLGPQFMRAIVTGEKLRL 905
                 |:.....:|       :::|:|      ||       .|.|   ||.|.:::|.|..||
Human   916 RMGSPEERRQNSVSDFPPPAGREFILR------TTVPRPAPYSKAL---PQRMYSVLTKEDFRL 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31935	NP_608608.2	Rab3-GTPase_cat	578..726	CDD:290601	83/154 (54%)
RAB3GAP1	XP_011509125.1	Rab3-GTPase_cat	612..769	CDD:290601	84/157 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146994
Domainoid	1	1.000	214	1.000	Domainoid score	I2744
eggNOG	1	0.900	-	-		E1_KOG2390
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45617
Inparanoid	1	1.050	367	1.000	Inparanoid score	I2157
Isobase	1	0.950	-	0	Normalized mean entropy	S6808
OMA	1	1.010	-	-		QHG59936
OrthoDB	1	1.010	-	-		D105289at33208
OrthoFinder	1	1.000	-	-		FOG0005064
OrthoInspector	1	1.000	-	-		oto89906
orthoMCL	1	0.900	-	-		OOG6_103581
Panther	1	1.100	-	-	LDO	PTHR21422
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2744
SonicParanoid	1	1.000	-	-		X3584
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750