Protein Alignment CG31935 and Rab3gap1

DIOPT Version :9

• Sequence 1: NP_608608.2
• Gene: CG31935 / 33338
• FlyBaseID: FBgn0051935
• Length: 916
• Species: Drosophila melanogaster
• Sequence 2: XP_006529468.1
• Gene: Rab3gap1 / 226407
• MGIID: 2445001
• Length: 988
• Species: Mus musculus
• Alignment Length: 1042
• Identity: 317/1042 - (30%)
• Similarity: 485/1042 - (46%)
• Gaps: 190/1042 - (18%)

  Fly     4 EIDDNEFYRENFSADSDWEVFNAQLGEILQKWDVSSDSETRNLKSEEIFSCNWKVEREKLDMLRN 68
            |.:...|...:|:..|:||.|.:::.|:|..|.:...|..:.|:.....|..|:...:::.....
Mouse     6 EPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGPSLGKPLEKGIFTSGTWEERSDEISFADF 70

  Fly    69 GIEVEYHQAILE-------DEELVRAEAKEITCLQRTSCHHDLMSTGNSFGPPIRSSQELHILAR 126
            ...|.:|..:.|       ||||..|..:.:         .||:...|.|.|      ..|.|.|
Mouse    71 RFSVTHHYLVQESPDKERKDEELEDAIPQSM---------QDLLCMNNDFPP------RAHCLVR 120

  Fly   127 IYGLRRFIVLHPVNPTLNYMRSTSEFNFFLSAVAVVSAEVQSLVPIFVQIYDPKW-NYYTGVALA 190
            .||||.|:|:.|...: :.:.|.|:.|..||::::........||:||||:. || ..|.|....
Mouse   121 WYGLREFVVIAPAAHS-DAVLSESKCNLLLSSISIALGNTGCQVPLFVQIHH-KWRRMYMGECQG 183

  Fly   191 PALRTNFRLIGLEKAPPECRFLMGLLTLFREKV--PTSYTQAAMISVCTTYAL-DTMRIRMPMYV 252
            |.:||:|.::.|.|.|.:...|.|||.:|:.|:  |.:......|::..||.| |..:...|...
Mouse   184 PGVRTDFEMVHLRKVPSQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRLTYVLQDWQQYFWPQQP 248

  Fly   253 PFDHGLSSEDIVVDGEVSHLEVQQFCALPHGYKPESRTEIYLVYTWPELSEHVAFDSEQRSDFVP 317
            |      ..|.:|.|||..||   |..||.|...:..:|::|..|||.|:|.:..|::..||..|
Mouse   249 P------DIDALVGGEVGGLE---FGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDP 304

  Fly   318 AKAPLGKIYLSVEASSYLSCCLRDYQS----VAEVTRSLESFVGRNFSGTSSGAEAA--SNPLDR 376
            .:||...:  .|..:....|.|.|:.:    :.....|.:..:||: :....|.|.|  ::.|.:
Mouse   305 VQAPHWSV--RVRKADNPQCLLGDFVTEFLKICRRKESTDEILGRS-TFEEEGREVADITHALSK 366

  Fly   377 ITE------HKLTK-----------RRERSFELPSQAGLTKRLPGPMTESELSELLAYLFPDMHP 424
            :||      |||:.           |:.|..|            .|:....|:.:|.:||||...
Mouse   367 LTEPAPVPIHKLSVSNMVHTAKKKIRKHRGEE------------SPLNSDVLNTILLFLFPDAVS 419

  Fly   425 EMALFPYAKKNFTDKFDPM----------RIKSAVPDSLVCRLSCLLATCHAHLGSVEGMAQVWA 479
            |.   |.......|...|.          :.|||..|||..:|:..|...:.:.|.::|:|.:|.
Mouse   420 EK---PLDGTTSIDNSIPAPEAGDYTLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQ 481

  Fly   480 AFTRQLRLLWDNSLMVPGISAGFPDTRTCLLHQKLQMLNVCVERRVQREANSKR----------- 533
            .|..::|..|:|:.::||:::|.||.|.|||||||||||.|:||:..|:...|.
Mouse   482 EFVLEMRFRWENNFLIPGLASGSPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSLSDSTTSAYP 546

  Fly   534 ----KSEGMVG---KASSEEEEDE--------DDDEGEFFDC----DDLTAGA------GSPTKA 573
                |:.|.:|   ...:|:|:.|        .|.|.|||:|    :||....      |.| |.
Mouse   547 GDAGKTGGQLGLDHLRDTEKEKGEVGKSWDSWSDSEEEFFECLSDTEDLKGNGQESGKKGGP-KE 610

  Fly   574 VLSLKPEGRLRRLNNERLLEEPDEYLYIPDTQEPVPKTEDQLQDDAEVMLKLG---PGSGLTTQM 635
            :.:|||||||.:.....||.. .|.||||.||||.|.|||.|::.:||:.|||   .|:.|..:|
Mouse   611 MANLKPEGRLHQHGKLTLLHN-GEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARM 674

  Fly   636 MCTSLLSDMEAFKAANPRGIMEDFIRWYSPKDW--EEVTDELGQV--KHQLSIRMTTEGNTWQKV 696
            ....||||||:||||||...:|||:|||||:|:  ||||||.|.|  |.:||.||....|.|.:.
Mouse   675 QSACLLSDMESFKAANPGCFLEDFVRWYSPRDYIEEEVTDEKGNVVLKGELSARMKIPSNMWVEA 739

  Fly   697 WEQAQAVPVSRQKRLFDDTNEALKVLHYLETRKMHEIYNLTVIPLLHSAILKLADILSNAELEDL 761
            ||.|:.||..||:||||||.||.||||||..:|..::....:..::|:|:||:.:   ...||::
Mouse   740 WETAKPVPARRQRRLFDDTREAEKVLHYLAMQKPADLARHLLPCVIHAAVLKVKE---EESLENI 801

  Fly   762 FSSQIEKLLSDLCRLSRSHSD------------------ELPSIKPLLDDLAELERRFYQFKC-- 806
            .|  ::|::..:.    :||.                  ::.:::.::.....|:.:|...||
Mouse   802 PS--VKKIIKQII----AHSSKVLHFPNPEDKKLEEIILQITTVEAIIARARSLKAKFGTEKCEH 860

  Fly   807 FERLSGYPKRSS--LQQVKLQFEEILRNDNCCTIVNR------RLTAAGDGTLYDILIPKLE--- 860
            .|...|..:..|  |:|.::......|. :...|:::      |||.:.|... .:.:|:.|
Mouse   861 EEEKEGLERFVSCLLEQPEVSVTGAGRG-HAGRIIHKLFVNAQRLTESSDEAA-AVALPEEELKK 923

  Fly   861 ----EDMADRLIS-------KDYIIRLDGDTKTT-EKGLYLGPQFMRAIVTGEKLRLCGAFTEST 913
                |:....|:|       ::.|:|........ .|.|   ||.|.:::|.|..||.|||:..|
Mouse   924 SGCPEERRQTLVSDFPPPAGRELILRATVPRPAPYSKAL---PQRMYSVLTKEDFRLAGAFSSDT 985

  Fly   914 AF 915
            :|
Mouse   986 SF 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31935	NP_608608.2	Rab3-GTPase_cat	578..726	CDD:290601	86/154 (56%)
Rab3gap1	XP_006529468.1	Rab3-GTPase_cat	612..769	CDD:372788	87/157 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836937
Domainoid	1	1.000	211	1.000	Domainoid score	I2807
eggNOG	1	0.900	-	-		E1_KOG2390
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45617
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2129
Isobase	1	0.950	-	0	Normalized mean entropy	S6808
OMA	1	1.010	-	-		QHG59936
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005064
OrthoInspector	1	1.000	-	-		oto93483
orthoMCL	1	0.900	-	-		OOG6_103581
Panther	1	1.100	-	-	LDO	PTHR21422
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2744
SonicParanoid	1	1.000	-	-		X3584
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740