DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10869 and QRICH2

DIOPT Version :9

Sequence 1:	NP_608605.1	Gene:	CG10869 / 33337	FlyBaseID:	FBgn0031347	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	NP_001375382.1	Gene:	QRICH2 / 84074	HGNCID:	25326	Length:	1887	Species:	Homo sapiens

Alignment Length:	763	Identity:	161/763 - (21%)
Similarity:	262/763 - (34%)	Gaps:	261/763 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 PPAEEAEAPPAP-VEEPPAADPA--------PEPAPEPAPEPAAEEPAPAEPVPEEAAPAEAAAP 144
            ||..|.....:| :.....|.|.        ||...:....|..::.:|              .|
Human  1013 PPGREQYGQVSPLLASQGLASPGIDRRSLVPPETYQQGLMHPGTDQHSP--------------IP 1063

  Fly   145 SPEPVGSNH-EPTPSATPAPEEHPPSEPEA-------------DTS----KAPMDVPAEAKGEE- 190
            ....:||.| :....|:|.|.||....|:|             |:.    :.|..:.|:..|:|
Human  1064 LSTGLGSTHPDQQHVASPGPGEHDQVYPDAAQHGHAFSLFDSHDSMYPGYRGPGYLSADQHGQEG 1128

  Fly   191 LAPQASRVSSR-------SSGRD----KSHSQTD-----GSLTNNLLRLERR------------- 226
            |.|..:|.|.|       :.|:|    :|....|     ||..::.:..|||
Human  1129 LDPNRTRASDRHGIPAQKAPGQDVTLFRSPDSVDRVLSEGSEVSSEVLSERRNSLRRMSSSFPTA 1193

  Fly   227 ---------LSKI---------ELQKEQA---TMEVQQFVSNLTSQLKITM-----EQVNNMTHL 265
                     ||.:         :|.:|||   .:|..||:  |...:|.|:     ||:..:..|
Human  1194 VETFHLMGELSSLYVGLKESMKDLDEEQAGQTDLEKIQFL--LAQMVKRTIPPELQEQLKTVKTL 1256

  Fly   266 ----------------LIDRKPNPQRFRLLR--HIAKQLRVLMVTTGD----------------- 295
                            :::.:.|.:..:.|:  .:..||.||.||..|
Human  1257 AKEVWQEKAKVERLQRILEGEGNQEAGKELKAGELRLQLGVLRVTVADIEKELAELRESQDRGKA 1321

  Fly   296 --EVSVSWSSGDIVDGVEEEGLSEEEVPVESS---------------APTEVEKPEEEEELELEQ 343
              |.|||.:|..:.|.:::..:..|.:...||               ||.:::.       |...
Human  1322 AMENSVSEASLYLQDQLDKLRMIIESMLTSSSTLLSMSMAPHKAHTLAPGQIDP-------EATC 1379

  Fly   344 PLCYSPEKMLTELLDLKSQFCALTNK-------VNELAAALLKQDSQRLMDQMKDLSETVRDIKL 401
            |.|         .||:..|...|..:       ||.||.:...:.: :|..|.::|...|:...|
Human  1380 PAC---------SLDVSHQVSTLVRRYEQLQDMVNSLAVSRPSKKA-KLQRQDEELLGRVQSAIL 1434

  Fly   402 YMASNKEATNGMMTRLNDCVYQ----IQVLKKSASHLDEVKIDKTEVELLLAEKVDFQQLATKVS 462
            .:..:.|..|...:.|.:...|    |.:|.:....|::.|.::..:|:.:..|.|...||||||
Human  1435 QVQGDCEKLNITTSNLIEDHRQKQKDIAMLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVS 1499

  Fly   463 LEQLEEYKARLEQMFCEVRHIVSLNEKNVLQIIDNL--RMTLGIDALELSLKDFREMIERRVQII 525
            ..|.:....:|..|..|:...:|..|::..:::|.|  .|...:|.|||.  ..::::|.|.:.:
Human  1500 RVQFDATTEQLNHMMQELVAKMSGQEQDWQKMLDRLLTEMDNKLDRLELD--PVKQLLEDRWKSL 1562

  Fly   526 AEALQKYMEMTNDDCAAAAGRVKVMQDLACLACDTTCVMRTVER-------SKVPSLPNAKGSTG 583
            .:.|::...:...| .|||.|.:::....||:||     |.:|.       ...|:.|...|...
Human  1563 RQQLRERPPLYQAD-EAAAMRRQLLAHFHCLSCD-----RPLETPVTGHAIPVTPAGPGLPGHHS 1621

  Fly   584 LGPIVTYELGQIR------KSGIMGYYRKDEFPHSTSAW-------------------------- 616
            :.|...:||.|:|      |.|       ..||....|.
Human  1622 IRPYTVFELEQVRQHSRNLKLG-------SAFPRGDLAQMEQSVGRLRSMHSKMLMNIEKVQIHF 1679

  Fly   617 ---TKGAS------------GVPMVK-----------CTPRHAGGSHT 638
               ||.:|            |.|..|           ..||..|||||
Human  1680 GGSTKASSQIIRELLHAQCLGSPCYKRVTDMADYTYSTVPRRCGGSHT 1727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10869	NP_608605.1	DUF4795	378..562	CDD:292662	47/189 (25%)
QRICH2	NP_001375382.1	Glutenin_hmw	478..980	CDD:367362
		SMC_prok_B	<1176..1544	CDD:274008	80/386 (21%)
		DUF4795	1418..1598	CDD:406451	48/187 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I12026
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207370at33208
OrthoFinder	1	1.000	-	-		FOG0012568
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107554
Panther	1	1.100	-	-	LDO	PTHR46766
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920