DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10869 and 4930562C15Rik

DIOPT Version :9

Sequence 1:	NP_608605.1	Gene:	CG10869 / 33337	FlyBaseID:	FBgn0031347	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	NP_084468.1	Gene:	4930562C15Rik / 78809	MGIID:	1926059	Length:	1145	Species:	Mus musculus

Alignment Length:	758	Identity:	158/758 - (20%)
Similarity:	264/758 - (34%)	Gaps:	239/758 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GSP-----ESGHVNFYALH---------VLLTCFAQRLEVLDEVVEQED---------YMVANVR 55
            |||     ::|:::. .:|         .|.|..|.|.|.|...||..|         ::....|
Mouse   252 GSPLEQPEDAGYIHI-PIHSATPVPTMVQLGTTGALREEELTRAVELADSQRPELAQAFVSQTQR 315

  Fly    56 LQSSLLTLGNTSKFRLFAGADAEEGAAAEPAAEPPAEEAEAP-------------PAPVEEPPAA 107
            |:.:..::..|.:.         |.|.|..:.....|.|:|.             |.||   |..
Mouse   316 LERAQASVSQTQRL---------ERAQASVSQTQRLERAQASVSQTQNLRQTAPFPFPV---PGF 368

  Fly   108 DPAPEPAPEPAPEPAAEEPA--------------------PAEPVPEEAAPAEAAAPSPE----P 148
            .|.|:..|...|.|....|:                    |.:|   ...|.:...|.|.    .
Mouse   369 VPGPDFMPVYGPRPGMATPSAWALPRGLARGNYWPIWGIGPYQP---GQGPLQPMGPMPRVPFPA 430

  Fly   149 VGSN---HEPTPSAT---PAPEEHPP----SEPEADTSKAPMDVPAEAKGEELAPQASRVSSRSS 203
            :||:   .:|.|..|   |..||..|    ..||....:.|||   ||..||:|..
Mouse   431 MGSDIPWTQPLPQGTQWYPNIEERGPEYEEQYPEGYQEEMPMD---EAPQEEMAVY--------- 483

  Fly   204 GRDKSHSQTDGSLTNNLL--RLERRLSKIELQKEQATME------VQQFVSNLTSQLKITMEQVN 260
            |..:....|:|:..:.:.  |...|:||.::.|.:...|      ..:.||...:..|....:|.
Mouse   484 GALEEEIPTEGAPQDGIPKGRARERISKEKVPKYRTPKERVSYHKASKDVSPEDTGTKDEAPEVK 548

  Fly   261 NMTHLLI------DRKPNPQR------FRLLRHI------------------------------- 282
            .:..::.      |:.|.|:|      .:.||..
Mouse   549 VLKKVVYKDRPQKDKAPEPRRKGPSSAIKKLRSAIASAAAAAAAYAAHANSAAQLAKDAVKAIQD 613

  Fly   283 --AKQL---RVLMVTTG------DEVSVSWSSGDIVDGVEEEGLSEEEVPVESSAP--------- 327
              |.||   ..|:.::|      |.:...:..|...:...:|| ..||.|.|.:||
Mouse   614 VPANQLAAKAALIASSGPLGAFADFLGAGFGHGATSNTPFDEG-ELEEFPEEFAAPFNPFTSKPV 677

  Fly   328 --------TEVEKPEEEEELELEQPLCYSP---EKMLTELLDLKSQF----CALTNKVNELA--- 374
                    |:...|||:     ::.:.||.   .:|.:....||.:|    ..|..::|.||
Mouse   678 LSQAMISATQATSPEEK-----KKAVQYSMGHIAQMPSRHNSLKEEFTNLSTTLNQRLNYLANMG 737

  Fly   375 ---------------------AALLKQDSQRL----MDQMKDLSETVRDIKLYMASNKEATNGMM 414
                                 |.|.:::.:|:    :|.||         ..||..:: |...:.
Mouse   738 SSGVLGSTVNVLEEKIINLQKARLQEEELERVWGHQIDTMK---------SHYMVLDR-AVERLQ 792

  Fly   415 TRLNDCVYQIQVLKKSASHLDEVKIDKTEVELLLAEKVDFQQLATKVSLEQLEEYKARLEQMFCE 479
            .|::|    :::||.....||.||.||..::|.|.||.:...||:|.:...||.....|.:|...
Mouse   793 IRMDD----LKILKAEIERLDLVKADKNVMDLELNEKANRDALASKANRVDLETVAMELNEMIHS 853

  Fly   480 VRHIVSLNEKNVLQIIDNLRMTLGIDALELSLKDFREMIERRVQIIAEALQKYMEMTNDDCAAAA 544
            :...::..|.:..:.:.:||..|....::..|...::.||...:::.:.|.:.:....|  :||.
Mouse   854 MLLKITNYESDWKKALKHLRKDLNTKLVQSDLNSLKKDIEEVWKVVRKLLLEGLRFDPD--SAAG 916

  Fly   545 GRVKVMQDLACLACDTTCVMRTVERSKVPSLPNAKGSTGLGPI 587
            .:.|:.:.:.|::||     |.||....|.|...:.:.||..|
Mouse   917 FKKKLFERVKCISCD-----RPVEMMTGPQLITIRNTHGLSRI 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10869	NP_608605.1	DUF4795	378..562	CDD:292662	43/187 (23%)
4930562C15Rik	NP_084468.1	V_Alix_like	<68..>195	CDD:187408
		Cytadhesin_P30	<314..472	CDD:284643	35/172 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..577		16/87 (18%)
		DUF4795	760..934	CDD:292662	45/194 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1145
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11082
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207370at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010