DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18132 and Pdia6

DIOPT Version :9

Sequence 1:	NP_608603.1	Gene:	CG18132 / 33333	FlyBaseID:	FBgn0031345	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_082235.2	Gene:	Pdia6 / 71853	MGIID:	1919103	Length:	440	Species:	Mus musculus

Alignment Length:	161	Identity:	37/161 - (22%)
Similarity:	65/161 - (40%)	Gaps:	27/161 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LSKQSGNVTTITNLSVKARSADQCTPGTILKLRVDNFFETTEDG--TFFVKFYEPNCMGCHDFET 86
            |..:||..:     |.|....|..:...:::|..|.|.:...|.  .:.|:||.|.|..|.:.|.
Mouse   139 LGGRSGGYS-----SGKQGRGDSSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEP 198

  Fly    87 TWTDMAKSFK--SKENICFAELNCKFAKTICNDYELRYEPNLIWLENGEEVQQYDG-----DLTS 144
            .|...|...|  :|..:..|.::....:.:.:.|.::..|.:...:.||....|||     |:.|
Mouse   199 EWAAAATEVKEQTKGKVKLAAVDATMNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVS 263

  Fly   145 PGIKIF--------VWEMIRRNETNKSAAKR 167
            ..:.:|        :.|:|     |:..||:
Mouse   264 RALDLFSDNAPPPELLEII-----NEDIAKK 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18132	NP_608603.1	Thioredoxin_like	51..151	CDD:294274	26/116 (22%)
Pdia6	NP_082235.2	PDI_a_P5	26..128	CDD:239299
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..161		6/26 (23%)
		PDI_a_P5	161..266	CDD:239299	25/104 (24%)
		P5_C	275..404	CDD:239281	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..440
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	437..440
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000934
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000