DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18132 and PDIA6

DIOPT Version :9

Sequence 1:	NP_608603.1	Gene:	CG18132 / 33333	FlyBaseID:	FBgn0031345	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_001269633.1	Gene:	PDIA6 / 10130	HGNCID:	30168	Length:	492	Species:	Homo sapiens

Alignment Length:	161	Identity:	39/161 - (24%)
Similarity:	67/161 - (41%)	Gaps:	27/161 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LSKQSGNVTTITNLSVKARSADQCTPGTILKLRVDNFFETTEDG--TFFVKFYEPNCMGCHDFET 86
            |..:||..:     |.|...:|..:...:::|..|:|.:...|.  .:.|:||.|.|..|.:.|.
Human   191 LGGRSGGYS-----SGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEP 250

  Fly    87 TWTDMAKSFK--SKENICFAELNCKFAKTICNDYELRYEPNLIWLENGEEVQQYDG-----DLTS 144
            .|...|...|  :|..:..|.::....:.:.:.|.:|..|.:...:.||....|||     |:.|
Human   251 EWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVS 315

  Fly   145 PGIKIF--------VWEMIRRNETNKSAAKR 167
            ..:.:|        :.|:|     |:..|||
Human   316 RALDLFSDNAPPPELLEII-----NEDIAKR 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18132	NP_608603.1	Thioredoxin_like	51..151	CDD:294274	27/116 (23%)
PDIA6	NP_001269633.1	PDI_a_P5	78..180	CDD:239299
		PDI_a_P5	213..318	CDD:239299	26/104 (25%)
		P5_C	327..456	CDD:239281	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000934
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810