Protein Alignment CG31661 and Bace2

DIOPT Version :10

• Sequence 1: NP_722707.1
• Gene: CG31661 / 33330
• FlyBaseID: FBgn0051661
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_062390.3
• Gene: Bace2 / 56175
• MGIID: 1860440
• Length: 514
• Species: Mus musculus
• Alignment Length: 387
• Identity: 99/387 - (25%)
• Similarity: 162/387 - (41%)
• Gaps: 80/387 - (20%)

  Fly    57 PLR-TVNAV----NVTSESGKGVVITEPLINSYDTNFFGVVSVGDQSFTMQFDTGSSDFWV---P 113
            |:| |.|.:    |:..:||:|..: |.||.:           ..|...:..|||||:|.|   |
Mouse    66 PVRATANFLAMVDNLQGDSGRGYYL-EMLIGT-----------PPQKVQILVDTGSSNFAVAGAP 118

  Fly   114 SSHCRFCIKTCGNKFFRKSNSKSFRSSGTPFSITYGSGSVKGIVASDNV----GFGDLKIQNQGI 174
            .|:.        :.:|...:|.::.|.|...::.|..||..|.|..|.|    ||....:.|
Mouse   119 HSYI--------DTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVN--- 172

  Fly   175 GLVNISDSCSVF------DGIAGFAFQQLSM-TKSVPSFQQMIDQQLVEQPIFSFHL------KS 226
             :..|.:|.:.|      :||.|.|:..|:. :.|:.:|...:..|.....|||..:      .:
Mouse   173 -IATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVA 236

  Fly   227 GS-SDGGSMILGGSNSSLYYGPLTYTNVTEAKYWSFKLDFIAVHGKGSR---SSRTGNKAIMDTG 287
            || ::|||::|||...|||.|.:.||.:.|..|:..::..:.:.|:...   .....:|||:|:|
Mouse   237 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDSG 301

  Fly   288 TSLIVGP------VLEVLYINKDIGAEHNKTYNLYTVACESIPQLPIIVF---------GIAGKE 337
            |:|:..|      |:|.:.....|....:..:....:||.:..:.|...|         ..|.:.
Mouse   302 TTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRS 366

  Fly   338 F--FVKPHTYV-------IRYDNFCFSAFMDMLGLQYWILGDAFMRENYVEFDWARRRMGIA 390
            |  .:.|..|:       ..|:.:.|........|   ::|...|...||.||.|:||:|.|
Mouse   367 FRITILPQLYIQPMMGAGFNYECYRFGISSSTNAL---VIGATVMEGFYVVFDRAQRRVGFA 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31661	NP_722707.1	Asp	88..392	CDD:394983	88/351 (25%)
Bace2	NP_062390.3	beta_secretase_like	85..446	CDD:133140	93/368 (25%)