DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31661 and BACE1

DIOPT Version :9

Sequence 1:	NP_722707.1	Gene:	CG31661 / 33330	FlyBaseID:	FBgn0051661	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens

Alignment Length:	376	Identity:	86/376 - (22%)
Similarity:	154/376 - (40%)	Gaps:	75/376 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 NVTSESGKGVVITEPLINSYDTNFFGVVSVGD--QSFTMQFDTGSSDFWVPSSHCRFCIKTCGNK 127
            |:..:||:|              ::..::||.  |:..:..|||||:|.|.::...|.     ::
Human    66 NLRGKSGQG--------------YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL-----HR 111

  Fly   128 FFRKSNSKSFRSSGTPFSITYGSGSVKGIVASD--NVGFGDLKIQNQGIGLVNISD----SCSVF 186
            ::::..|.::|.......:.|..|..:|.:.:|  ::..|........|..:..||    :.|.:
Human   112 YYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNW 176

  Fly   187 DGIAGFAFQQLSMTKS--VPSFQQMIDQQLVEQPIFSFHLKSG----------SSDGGSMILGGS 239
            :||.|.|:.:::....  .|.|..::.|..|.. :||..|...          :|.|||||:||.
Human   177 EGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVGGSMIIGGI 240

  Fly   240 NSSLYYGPLTYTNVTEAKYWSFKLDFIAVHGKGSR---SSRTGNKAIMDTGTSLIVGP--VLEVL 299
            :.|||.|.|.||.:....|:...:..:.::|:..:   .....:|:|:|:||:.:..|  |.|..
Human   241 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAA 305

  Fly   300 YINKDIGA--------------EHNKTYNLYTVACESIPQLPIIVFGIAGKEFF---VKPHTYV- 346
            .  |.|.|              |....:...|......|.:.:.:.|....:.|   :.|..|:
Human   306 V--KSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLR 368

  Fly   347 -------IRYDNFCFSAFMDMLGLQYWILGDAFMRENYVEFDWARRRMGIA 390
                   .:.|.:.|:......|.   ::|...|...||.||.||:|:|.|
Human   369 PVEDVATSQDDCYKFAISQSSTGT---VMGAVIMEGFYVVFDRARKRIGFA 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31661	NP_722707.1	pepsin_retropepsin_like	78..391	CDD:299705	82/363 (23%)
CG31661	NP_722707.1	Asp	88..392	CDD:278455	82/353 (23%)
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58
		beta_secretase_like	72..437	CDD:133140	84/370 (23%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900