Protein Alignment CG31661 and CTSE

DIOPT Version :9

• Sequence 1: NP_722707.1
• Gene: CG31661 / 33330
• FlyBaseID: FBgn0051661
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: XP_011507546.1
• Gene: CTSE / 1510
• HGNCID: 2530
• Length: 401
• Species: Homo sapiens
• Alignment Length: 421
• Identity: 141/421 - (33%)
• Similarity: 203/421 - (48%)
• Gaps: 51/421 - (12%)

  Fly     3 IRVIILLFCLIVFVGGKK--VHRFRLERRSHRHHKIPHAHLHLQFRNALRRKYGFTPLRTVNAVN 65
            ::.::||..:::.:|..:  :||..|.|.       |.....|:.|:.|..   |.....::.:.
Human     1 MKTLLLLLLVLLELGEAQGSLHRVPLRRH-------PSLKKKLRARSQLSE---FWKSHNLDMIQ 55

  Fly    66 VTSESGKGVVITEPLINSYDTNFFGVVSVGD--QSFTMQFDTGSSDFWVPSSHCRF-CIKTCGNK 127
            .|..........|||||..|..:||.:|:|.  |:||:.||||||:.||||.:|.. ..||  :.
Human    56 FTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKT--HS 118

  Fly   128 FFRKSNSKSFRSSGTPFSITYGSGSVKGIVASDNVGFGDLKIQNQGIGLVNISDSCSV------- 185
            .|:.|.|.::...|..|||.||:||:.||:.:|.|  .....|.:|:.:|......||
Human   119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQV--SAFSYQVEGLTVVGQQFGESVTEPGQTF 181

  Fly   186 ----FDGIAGFAFQQLSMTKSVPSFQQMIDQQLVEQPIFSFHLKSGSSDG-GS-MILGGSNSSLY 244
                ||||.|..:..|::....|.|..|:.|.||:.|:||.::.|....| || :|.||.:.|.:
Human   182 VDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHF 246

  Fly   245 YGPLTYTNVTEAKYWSFKLDFIAVHGKGSRSSRTGNKAIMDTGTSLIVGPVLEVLYINKDIGAEH 309
            .|.|.:..||:..||...||.|.|.|.....|. |.:||:|||||||.||..::..:...|||.
Human   247 SGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSE-GCQAIVDTGTSLITGPSDKIKQLQNAIGAA- 309

  Fly   310 NKTYNLYTVACESIPQLPIIVFGIAGKEFFVKPHTYVIRYD-----NFCFSAFMDMLGLQ----- 364
             .....|.|.|.::..:|.:.|.|.|..:.:.|..|.: .|     .||.|.|.   ||.
Human   310 -PVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTL-LDFVDGMQFCSSGFQ---GLDIHPPA 369

  Fly   365 --YWILGDAFMRENYVEFDWARRRMGIAPAV 393
              .|||||.|:|:.|..||....|:|:||||
Human   370 GPLWILGDVFIRQFYSVFDRGNNRVGLAPAV 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31661	NP_722707.1	pepsin_retropepsin_like	78..391	CDD:299705	124/340 (36%)
		Asp	88..392	CDD:278455	119/331 (36%)
CTSE	XP_011507546.1	A1_Propeptide	21..49	CDD:285240	9/37 (24%)
		Asp	77..399	CDD:278455	119/332 (36%)
		Cathespin_E	78..398	CDD:133153	118/330 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151480
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950