DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment robo3 and Robo2

DIOPT Version :9

Sequence 1:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster
Sequence 2:XP_038944599.1 Gene:Robo2 / 84409 RGDID:620167 Length:1625 Species:Rattus norvegicus


Alignment Length:1508 Identity:456/1508 - (30%)
Similarity:660/1508 - (43%) Gaps:265/1508 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDLRFVFIVF-----LLKWTHA--------------QGSHPPRIVEHPIDTTVPRHEPATLNCKA 46
            ::|.||.::|     |.|.|..              |...||||||||.|..|.:.||.||||||
  Rat    13 LELLFVLMLFFAGPTLGKLTRTPWKGKPWKGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKA 77

  Fly    47 EGSPTPTIQWYKDGVPL---KILPGSHRITLPAGGLFFLKVVNSRR-ETDAGIYWCEAKNELGVA 107
            ||.|||||:|||||..:   |..|.|||:.||:|.||||::|:.|| :.|.|.|.|.|:|.||.|
  Rat    78 EGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGTYVCVARNYLGEA 142

  Fly   108 RSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECAAPRGIPEPTVTWKKGGQKLDLEGSKRVRI 172
            .||||:|:||:|||:||..|.:..:|.|:.|:|||..|||.||||:.|||...::| |..:|:.|
  Rat   143 VSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID-EKEERISI 206

  Fly   173 VDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLATLKVHVKPYIIRGPHDQTVLEGASVTFPCR 237
             .||.|.|.:.|::|.|.|.|:..|.||.|:|..|.|.|..:|..:|.|.:|.|||.....|.|:
  Rat   207 -RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEDEPAEFRCQ 270

  Fly   238 VGGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRLERVTIADEGEYSCEADNVVGAITAMGTLTV 302
            |.|||.|.|.|.:  ...::|..|..:.:|.:||:::...||||.|.|.|:|.||.:.|..||||
  Rat   271 VQGDPQPTVRWKK--DDADLPRGRYDIKDDYTLRIKKAISADEGTYVCIAENRVGKVEASATLTV 333

  Fly   303 ----YAPPKFIQRPASKSVELGADTSFECRAIGNPKPTIFWTIKNNSTLIFPGAP--PLDRFHSL 361
                .|||:|:.||..:.|..|...:|.|...|||:|.:||..:.:..|:||..|  |..|....
  Rat   334 RVRPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVS 398

  Fly   362 NTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQLSL-DSQEDRPPPIIISGPVNQTLPI 425
            .|.:    ||:|..||:|....| |.|:....||.::.||.: |...|||||||:.||:||||.:
  Rat   399 PTGD----LTITNIQRSDAGYYI-CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPINQTLAV 458

  Fly   426 KSLATLQCKAIGLPSPTISWYRDGIP-VQPSSKLNITTSGDLIISDLDRQQDQGLYTCVASSRAG 489
            ...|.|:|||.|.|.|.|||.::|.. :....:..|...|.|.|.:| |..|.|.|||||:|.:|
  Rat   459 DGTALLKCKATGEPLPVISWLKEGFTFLGRDPRATIQDQGTLQIKNL-RISDTGTYTCVATSSSG 522

  Fly   490 KSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAPGQPKILNATASALTIVWPTSDKAGASSFL--- 551
            :::||..|.:   |.......:..:....|..|.:|::.:.|.:::|:.|    :.|....|   
  Rat   523 ETSWSAVLDV---TESGATISKNYDTNDLPGPPSKPQVTDVTKNSVTLSW----QPGTPGVLPAS 580

  Fly   552 GYSVEMYCTNQSRTWIPIASRLSEPIFTVESLTQGAAYMFIVRAENSLGFSPPSPISEPITAGKL 616
            .|.:|.:..:.|.:|..:|:.:...::||..|.....|:|:|||.|..|.|.|||:|:|:....:
  Rat   581 AYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDI 645

  Fly   617 VGVRDGSESTGTSQLLLSDVETLLQANDVVELLEANASDSTTARLSWDID-SGQYIEGFYLYARE 680
            .....|.:.... |..|.||...|. |.||       ...||.:::|.:| ..|:|:|:.:..|:
  Rat   646 SPPAQGVDHRQV-QKELGDVTVRLH-NPVV-------LTPTTVQVTWTVDRQPQFIQGYRVMYRQ 701

  Fly   681 LHSSEYKMV--TLLNKGQGLSSCTVPGLAKASTYEFFLVPFYKSIVGKPSNSRRMRTLEDVPEAP 743
            ....:...|  .|..|.....|..:..|.|..|||..:.|::....|..|.|:.:||.|:.|.||
  Rat   702 TSGLQASTVWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTIRTTEEAPSAP 766

  Fly   744 PYGMEAI---QFNRTSVFLKWLPPQPNRTRNGILTSYNVVVKGLDVHNTTRIFKNMTIDAAAPTL 805
            |..:..:   ..|.||:.:.|.|| |...:|||:..|.:...|    |.||...|.|:||...::
  Rat   767 PQSVTVLTVGSHNSTSISVSWDPP-PADHQNGIIQEYKIWCLG----NETRFHINKTVDATIRSV 826

  Fly   806 LLANLTTGVTYYIAVAAATRVGVGPFSKPAVLRIDARTQSLDTGYTRYPISRDIADDFLTQTWFI 870
            ::..|..|:.|.:.|||:|..|||..|:|..:.|..|.:.:.| .....|:..|. |.:.|..||
  Rat   827 VIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGGRNEVVIT-ENNNSITEQIT-DVVKQPAFI 889

  Fly   871 VLLGSIIAIIVF---------------LLGALVLFKR---------------------YQFIKQ- 898
            ..:|....:|:.               |....|.|:|                     |.::.. 
  Rat   890 AGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNTGDPSYPWLADS 954

  Fly   899 ---TSL---GSLHGNHAIGT------------------VRK------------FPTLPLNG---- 923
               |||   .|..|.:.||.                  ::|            .|.:|..|    
  Rat   955 WPATSLPVNNSNSGPNEIGNFGRGDFKHNVNKNLAEHGIKKEFLGMERNKNDVLPPVPGQGDKTA 1019

  Fly   924 ----GGAVGA-----------GGSNSTAAA---------GQSGHGLWIDPTSGVWRQAAGGGNPG 964
                .||:.:           ..|..|.|.         ..|.|.|.:|.....|:         
  Rat  1020 TMLSDGAIYSSIDFTTKTTYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWK--------- 1075

  Fly   965 GVGSCTTKEQLPGYAQATAQQ--GQQPTL-LPDY---ERLS---PLNMPDYAEVACSTFKSPTHG 1020
              .|...|..|.|:|.:...|  |....| :|||   |.||   |.|.........|...|...|
  Rat  1076 --SSVQQKSDLMGFAYSLPDQNKGNNALLYIPDYRLAEGLSNRMPHNQSQDFSTTSSHNSSERSG 1138

  Fly  1021 APPMGGGGGGQSASLYDSCGAYATT-NVVANVKLYQNRYATKPNQSSGSNNNNH----QGNDYQS 1080
            :  :.||.||:.....:|..|.... :..|||.|     ...|.|........|    |.|.|.|
  Rat  1139 S--LSGGKGGKKKKTKNSSKAQKNNGSTWANVPL-----PPPPVQPLPGTELGHYPAEQENGYDS 1196

  Fly  1081 TGMYSAPP-----SAHYGCLEPKQQQQQQQPNLMTTSTA----------STAILTNSPAKVKKIN 1130
            ...  .||     ..|.|..:..::.:.:.|.......|          |||.||.||.:..: .
  Rat  1197 DSW--CPPLPVQTYLHQGMEDELEEDEDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQ-P 1258

  Fly  1131 ITENKMDQLEGKSERTNPFN-QQQQLLLASNALK-----QGLGAYANTTLAAQMASGGGAGTLRR 1189
            :.:..:|:|    .|...|: .:|...:.||...     ..|| ||:..|.:.:.:.........
  Rat  1259 MLQAHLDEL----TRAYQFDIAKQTWHIQSNTPPPQPPVPPLG-YASGALISDLETDVPDEDADD 1318

  Fly  1190 QRQPKTLYKSENNILGKSGLRQNTMNASV-GAPSNGQMDFLTGGPPSEGGDFSGLGLCNSTNQLL 1253
            :.:|..:.:....:....|...:.:::|| |:..||     .|....|..:|       |:::..
  Rat  1319 EEEPLEIPRPLRALDQTPGSSMDNLDSSVTGSMVNG-----WGSASDEDRNF-------SSHRSS 1371

  Fly  1254 NDWASSASIAAPGDYHFGSKQPSKQHLYVKAK------DGTWSAVSSDAYQSFKHQQQHHPFLAG 1312
            ...:|..||.|.|.:        .|.|...|.      |||....:..|:.|.:.|:...||   
  Rat  1372 VGSSSDGSIFASGSF--------AQALVAAADKAGFRLDGTSLTRTGKAFTSSQRQRPTSPF--- 1425

  Fly  1313 SGDNTKSLASVNS 1325
            |.|:..|.|...|
  Rat  1426 STDSNTSAAQNQS 1438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo3NP_608592.2 Ig 22..117 CDD:299845 59/98 (60%)
I-set 23..116 CDD:254352 58/96 (60%)
I-set 122..211 CDD:254352 39/88 (44%)
Ig 125..211 CDD:299845 37/85 (44%)
I-set 215..302 CDD:254352 34/86 (40%)
Ig 232..302 CDD:299845 27/69 (39%)
I-set 306..401 CDD:254352 32/96 (33%)
Ig 320..411 CDD:299845 32/93 (34%)
I-set 412..492 CDD:254352 36/80 (45%)
IGc2 429..489 CDD:197706 26/60 (43%)
FN3 519..612 CDD:238020 29/95 (31%)
FN3 644..735 CDD:238020 23/93 (25%)
fn3 743..832 CDD:278470 31/91 (34%)
Robo2XP_038944599.1 IgC_1_Robo 54..152 CDD:409490 58/97 (60%)
Ig strand B 71..75 CDD:409490 2/3 (67%)
Ig strand C 84..88 CDD:409490 2/3 (67%)
Ig strand E 111..115 CDD:409490 2/3 (67%)
Ig strand F 130..135 CDD:409490 2/4 (50%)
Ig strand G 144..147 CDD:409490 2/2 (100%)
Ig 159..244 CDD:416386 38/86 (44%)
Ig strand A 159..162 CDD:409353 1/2 (50%)
Ig strand A' 164..168 CDD:409353 0/3 (0%)
Ig strand B 172..179 CDD:409353 4/6 (67%)
Ig strand C 187..192 CDD:409353 2/4 (50%)
Ig strand C' 194..197 CDD:409353 0/2 (0%)
Ig strand D 203..207 CDD:409353 2/4 (50%)
Ig strand E 209..215 CDD:409353 3/5 (60%)
Ig strand F 222..230 CDD:409353 3/7 (43%)
Ig strand G 233..244 CDD:409353 5/10 (50%)
Ig 251..333 CDD:416386 33/83 (40%)
Ig strand A 251..254 CDD:409353 1/2 (50%)
Ig strand A' 256..260 CDD:409353 1/3 (33%)
Ig strand B 263..272 CDD:409353 2/8 (25%)
Ig strand C 278..283 CDD:409353 2/4 (50%)
Ig strand C' 286..289 CDD:409353 0/2 (0%)
Ig strand D 292..297 CDD:409353 1/4 (25%)
Ig strand E 298..305 CDD:409353 3/6 (50%)
Ig strand F 312..320 CDD:409353 4/7 (57%)
Ig strand G 323..333 CDD:409353 4/9 (44%)
IgI_4_Robo 342..439 CDD:409391 34/101 (34%)
Ig strand B 358..362 CDD:409391 1/3 (33%)
Ig strand C 371..375 CDD:409391 1/3 (33%)
Ig strand E 401..405 CDD:409391 1/7 (14%)
Ig strand F 415..420 CDD:409391 2/5 (40%)
Ig strand G 428..431 CDD:409391 0/2 (0%)
IgI_5_Robo 446..532 CDD:409544 38/86 (44%)
Ig strand B 462..466 CDD:409544 2/3 (67%)
Ig strand C 475..479 CDD:409544 2/3 (67%)
Ig strand E 498..502 CDD:409544 2/3 (67%)
Ig strand F 512..517 CDD:409544 3/4 (75%)
Ig strand G 525..528 CDD:409544 1/2 (50%)
FN3 549..642 CDD:238020 29/96 (30%)
FN3 673..758 CDD:238020 22/91 (24%)
FN3 767..859 CDD:238020 32/96 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 106 1.000 Domainoid score I6432
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 1 1.000 - - mtm9043
orthoMCL 1 0.900 - - OOG6_101537
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X493
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.810

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