DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo3 and Robo4

DIOPT Version :10

Sequence 1:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster
Sequence 2:XP_006510707.1 Gene:Robo4 / 74144 MGIID:1921394 Length:1074 Species:Mus musculus


Alignment Length:1354 Identity:252/1354 - (18%)
Similarity:424/1354 - (31%) Gaps:505/1354 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 PPRIVEHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPLKILPGSHRITLPAGGLFFLK-VV 85
            ||:|:.||.|..:....||.:.|::.|.|.|||:|..:|.||.:........||.|.|...: .|
Mouse    41 PPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSV 105

  Fly    86 NSRRETD-------AGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECA 143
            ..|.:.|       .|:|.|||.|.||.|.||.|.|.||||:::|:::|::|....|::.:|||.
Mouse   106 QGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECG 170

  Fly   144 APRGIPEPTVTWKKGGQKLDLEGSKRVRIVDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLAT 208
            .|.|.|:|:|:|.|.|:.|.|:..:|.  |.|.:|.:..|.:.|.|.|.|:|.|..|.|||..| 
Mouse   171 PPWGYPKPSVSWWKDGKPLVLQPGRRT--VSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAA- 232

  Fly   209 LKVHVKPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPLDRVSVLEDRS---- 269
                                                                |||:.|.:.    
Mouse   233 ----------------------------------------------------RVSIQESQDHKEH 245

  Fly   270 -------LRLERVTIADEGEYSCEADNVVGAITAMGTLTVYAPPKFIQRPASKSVELGADTSFEC 327
                   ::||.||:.:                          |:.::.|               
Mouse   246 LELLAVRIQLENVTLLN--------------------------PEPVKGP--------------- 269

  Fly   328 RAIGNPKPTIF--WTIKNNSTLIFPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMN 390
                .|.|:::  |.:..      |.||            ..|...|.|.||:.:|.        
Mouse   270 ----KPGPSVWLSWKVSG------PAAP------------AESYTALFRTQRSPRDQ-------- 304

  Fly   391 EVASITSRVQLSLDSQEDRPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRD-GIPVQP 454
                                     ..|..:.|    |..||...:|    .:.|.:| ...|:|
Mouse   305 -------------------------GSPWTEVL----LRGLQSAKLG----GLHWGQDYEFKVRP 336

  Fly   455 SSKLNITTSGDLIISDLDRQQDQGLYTCVASSRAGKSTWSGFLRIELPTNPNIKFYRAPEQTKCP 519
            ||                           ..:|...|              |:...|.|||.  |
Mouse   337 SS---------------------------GRARGPDS--------------NVLLLRLPEQV--P 358

  Fly   520 SAPGQPKILNATASALTIVW-PTSDKAGASSFLGYSVEMYCTNQSRTWIPIASRLSEPIFTVESL 583
            |||.|...|.:...::.:.| |...::......||.|          |            ::.:.
Mouse   359 SAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQV----------W------------SLGNA 401

  Fly   584 TQGAAYMFIVRAENSLGFSPPSPISEPITAGKLVGVRDGSESTGTSQLLLSDVETLLQANDVVEL 648
            :..||...:|..:..|..:...|.|..:....:.|...|..||                      
Mouse   402 SLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELST---------------------- 444

  Fly   649 LEANASDSTTARLSWDIDSGQYIEGFYLYARELHSSEYKMVTLLNKGQGLSSCTVPGLAKASTYE 713
                                                  .:..||.:|:.||..:.|...:.|..:
Mouse   445 --------------------------------------PVCLLLGEGKALSISSTPPPCRPSVSQ 471

  Fly   714 FFLVPFYKSI----------VGKP--SNSRRMRTLEDVPEAP----PYGMEAIQFN-------RT 755
            |....|..|:          :..|  |.|:..:.:|.....|    |:.:|.::..       .:
Mouse   472 FLSYIFSSSLSCLLVPLTVPLALPLSSTSQTEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIAS 536

  Fly   756 SVFLKWLPPQPNRTRNGILTSYNVVV---KGLDVHNTTRIFKNMTIDAA---------APTLLLA 808
            |..|.||          :|....|.:   :...||....:::..:.||.         :|.|...
Mouse   537 SAVLLWL----------LLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADT 591

  Fly   809 NLTTGVTYYIAVAA--ATRVGVGP----FSKPAVLRIDARTQSLDTGYTRYPISRDIADDFLTQT 867
            ..:|..:..::.::  ::|:|:.|    ..:.:::..|.|:..:       |:..|      |.|
Mouse   592 WRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGV-------PLLPD------TST 643

  Fly   868 WFIVLLGSIIAIIVFLLGALVLFKRYQFIKQTSLGSLHGNHAIGTVRKFPTLPLNGGGAVGAGGS 932
            ::    ||:||                  :|.|...:..:......|:||: .|.|..:..|...
Mouse   644 FY----GSLIA------------------EQPSSPPVRPSPKTPAARRFPS-KLAGTSSPWASSD 685

  Fly   933 NSTAAAGQSGHGLWIDPTSGVWRQAAGGGNPGGVGSCTTKEQLPGYAQATAQQGQQPTLLPDYER 997
            :..:..|.....:.:.||. .|:             ...|::|.....:...:|..|..:..:| 
Mouse   686 SLCSRRGLCSPRMSLTPTE-AWK-------------AKKKQELHQANSSPLLRGSHPMEIWAWE- 735

  Fly   998 LSPLNMPDYAEVACSTFKSPTHGAPPMGGGGGGQSASLYDSCGAYATTNVVANVKLYQNRYATKP 1062
                 :...|....|....|..|:|    |...::...:.:.|.....|   :.:|........|
Mouse   736 -----LGSRASKNLSQSPGPNSGSP----GEAPRAVVSWRAVGPQLHRN---SSELASRPLPPTP 788

  Fly  1063 NQSSGSNNNNHQGNDYQSTGMYSAP-----PSAHYGCLEPKQQQQQQQPNLMTTSTASTAILTNS 1122
            ....|:::::.|.   |......||     |:|....|...:....|...|...|.:|:      
Mouse   789 LSLRGASSHDPQS---QCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSS------ 844

  Fly  1123 PAKVKKINITENKMDQLEGKSERTNPFNQQQQLLLASNALKQGLGAYANTTLAAQMASG-----G 1182
                   |::.:.:..||.:.::.:....::                  ..|..:::.|     .
Mouse   845 -------NLSSSSLSSLEEEEDQDSVLTPEE------------------VALCLELSDGEETPTN 884

  Fly  1183 GAGTLRRQRQPKTLYKSENNILGKSGLRQNTMNASVGAPSNG---QMDFLTGGP-------PSEG 1237
            ....:.|...|.|.| ...:|...|||      |.:|....|   ::..|...|       ||||
Mouse   885 SVSPMPRAPSPPTTY-GYISIPTCSGL------ADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEG 942

  Fly  1238 GDFSGLGLCNSTNQLLNDWASSASIAAPGDYHFGSKQPSKQHLYVKAKDGTWSA 1291
                         .|.|.|.|::.          ...||.:...|.:.||::.|
Mouse   943 -------------SLANGWGSASE----------DNVPSARASLVSSSDGSFLA 973

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo3NP_608592.2 Ig 23..117 CDD:472250 37/101 (37%)
Ig strand B 40..44 CDD:409353 1/3 (33%)
Ig strand C 53..57 CDD:409353 2/3 (67%)
Ig strand E 77..81 CDD:409353 2/3 (67%)
Ig strand F 95..100 CDD:409353 2/4 (50%)
Ig strand G 109..112 CDD:409353 2/2 (100%)
Ig 124..211 CDD:472250 32/86 (37%)
Ig strand B 138..142 CDD:409353 1/3 (33%)
Ig strand C 152..156 CDD:409353 1/3 (33%)
Ig strand E 176..180 CDD:409353 1/3 (33%)
Ig strand F 190..195 CDD:409353 2/4 (50%)
Ig strand G 204..207 CDD:409353 1/2 (50%)
Ig 218..302 CDD:472250 8/94 (9%)
Ig strand B 232..236 CDD:409353 0/3 (0%)
Ig strand C 245..249 CDD:409353 0/3 (0%)
Ig strand E 268..272 CDD:409353 0/14 (0%)
Ig strand F 282..287 CDD:409353 0/4 (0%)
Ig strand G 295..298 CDD:409353 0/2 (0%)
Ig 307..403 CDD:472250 13/97 (13%)
Ig strand B 323..327 CDD:409353 0/3 (0%)
Ig strand C 336..340 CDD:409353 0/5 (0%)
Ig strand E 366..372 CDD:409353 1/5 (20%)
Ig strand F 382..388 CDD:409353 0/5 (0%)
Ig strand G 396..399 CDD:409353 0/2 (0%)
Ig 413..497 CDD:472250 14/84 (17%)
Ig strand B 429..433 CDD:409353 1/3 (33%)
Ig strand C 442..446 CDD:409353 0/3 (0%)
Ig strand E 464..468 CDD:409353 0/3 (0%)
Ig strand F 479..484 CDD:409353 0/4 (0%)
Ig strand G 492..495 CDD:409353 0/2 (0%)
FN3 519..612 CDD:238020 18/93 (19%)
FN3 644..735 CDD:238020 13/102 (13%)
fn3 743..832 CDD:394996 19/117 (16%)
Robo4XP_006510707.1 Ig 42..144 CDD:472250 37/101 (37%)
Ig strand B 59..63 CDD:409353 1/3 (33%)
Ig strand C 72..76 CDD:409353 2/3 (67%)
Ig strand E 96..100 CDD:409353 2/3 (67%)
Ig strand F 122..127 CDD:409353 2/4 (50%)
Ig strand G 136..139 CDD:409353 2/2 (100%)
Ig 151..236 CDD:472250 34/139 (24%)
Ig strand B 165..169 CDD:409353 1/3 (33%)
Ig strand C 179..183 CDD:409353 1/3 (33%)
Ig strand E 201..205 CDD:409353 1/3 (33%)
Ig strand F 215..220 CDD:409353 2/4 (50%)
Ig strand G 229..232 CDD:409353 1/2 (50%)
FN3 <267..>446 CDD:442628 54/381 (14%)
fn3 361..443 CDD:394996 17/103 (17%)

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