DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo3 and Robo1

DIOPT Version :10

Sequence 1:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster
Sequence 2:XP_063126810.1 Gene:Robo1 / 58946 RGDID:61941 Length:1662 Species:Rattus norvegicus


Alignment Length:1373 Identity:413/1373 - (30%)
Similarity:620/1373 - (45%) Gaps:264/1373 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 QGSHPPRIVEHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPL---KILPGSHRITLPAGGL 79
            |...||||||||.|..|.:.|||||||||||.|||||:|||.|..:   |..|.|||:.||:|.|
  Rat    70 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 134

  Fly    80 FFLKVVNSRR-ETDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECA 143
            |||::|:.|: ..|.|:|.|.|:|.||.|.|.||:|:||:|||:||..|.:..:|.|:.|::||.
  Rat   135 FFLRIVHGRKSRPDEGVYICVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 199

  Fly   144 APRGIPEPTVTWKKGGQKLDLEGSKRVRI-VDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLA 207
            .|||.||||::|||.|..||   .|..|| :.||.|.|...|::|.|:|.|:..|.||.|||.:|
  Rat   200 PPRGHPEPTISWKKDGSPLD---DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 261

  Fly   208 TLKVHVKPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRL 272
            .|.|..:|..::.|.:..|....|..|.|...|||:|.|.|.:  ..|.:|..|..:.:|.:|::
  Rat   262 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK--DDGELPKSRYEIRDDHTLKI 324

  Fly   273 ERVTIADEGEYSCEADNVVGAITAMGTLTVYAPPKFIQRPASKSVELGADTSFECRAIGNPKPTI 337
            .:||..|.|.|:|.|:|:||...|..||||..||.|:.:|..:.|.||...:|:|.|.|||:|.|
  Rat   325 RKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAI 389

  Fly   338 FWTIKNNSTLIFPGAPP--LDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQ 400
            ||..:.:..|:|...||  ..||....|.:    ||:|..||:|....| |..:|...||.::..
  Rat   390 FWRREGSQNLLFSYQPPQSSSRFSVSQTGD----LTVTNVQRSDVGYYI-CQTLNVAGSIITKAY 449

  Fly   401 LSL-DSQEDRPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQ-PSSKLNITTS 463
            |.: |...|||||:|..||||||:.:....||.|.|.|.|.|||.|.:||:.|. ..|::....|
  Rat   450 LEVTDVIADRPPPVIRQGPVNQTVAVDGTLTLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLES 514

  Fly   464 GDLIISDLDRQQDQGLYTCVASSRAGKSTWSGFLRIE---------LPTNPNIKFYRAPEQTKCP 519
            |.|.|. ..:..|.|.|||.||:.:|::|||.::.::         .||:||:          .|
  Rat   515 GVLQIR-YAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL----------IP 568

  Fly   520 SAPGQPKILNATASALTIVWPTSDKAGASSFLGYSVEMYCTNQSRTWIPIASRLSEPIFTVESLT 584
            |||.:|::.:.:.:.:|::|..:..:||:. ..|.:|.:......:|..:|..:....|.::.|.
  Rat   569 SAPSKPEVTDVSKNTVTLLWQPNLNSGATP-TSYIIEAFSHASGSSWQTVAENVKTETFAIKGLK 632

  Fly   585 QGAAYMFIVRAENSLGFSPPSPISEPITAGKLVGVRDGSESTGTSQLLLSDVETLLQANDVVELL 649
            ..|.|:|:|||.|:.|.|.||.||:|:....:.....|.:.....:.|         .|.|:.|.
  Rat   633 PNAIYLFLVRAANAYGISDPSQISDPVKTQDVPPTTQGVDHKQVQREL---------GNVVLHLH 688

  Fly   650 EANASDSTTARLSWDID-SGQYIEGFYLYARELHSS--EYKMVTLLNKGQGLSSCTVPGLAKAST 711
            ......|::..:.|.:| ..|||:|:.:..|...:|  |.:.:....:....:|..:|.|.|...
  Rat   689 NPTILSSSSVEVHWTVDQQSQYIQGYKILYRPSGASHGESEWLVFEVRTPTKNSVVIPDLRKGVN 753

  Fly   712 YEFFLVPFYKSIVGKPSNSRRMRTLEDVPEAPPYGMEAIQ--FNRTSVFLKWLPPQPNRTRNGIL 774
            ||....||:....|..|..:..:|||:.|.|||..:...:  .|.|::.:.|.|| |..|:||::
  Rat   754 YEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPRSVTVSKNDGNGTAILVTWQPP-PEDTQNGMV 817

  Fly   775 TSYNVVVKGLDVHNTTRIFKNMTIDAAAPTLLLANLTTGVTYYIAVAAATRVGVGPFSKPAVLRI 839
            ..|.|...|    |.||...|.|:|.:..::::.:|..|:.|.:.|||:|..|.|..|:|..:::
  Rat   818 QEYKVWCLG----NETRYHINKTVDGSTFSVVIPSLVPGIRYSVEVAASTGAGPGVKSEPQFIQL 878

  Fly   840 DARTQSLDTGYTRYPISRDIADDFLTQTWFIVLLGSIIAIIVFLLGALVLFKRYQFIKQTSLGSL 904
            |:....: :...:..:::.|: |.:.|..||..:|:...||:.:. ::.|::..:  |:..|.|.
  Rat   879 DSHGNPV-SPEDQVSLAQQIS-DVVKQPAFIAGIGAACWIILMVF-SIWLYRHRK--KRNGLSST 938

  Fly   905 HGNHAIGTVRKFPTLPL-------NGGGAVGAGGSNSTAAAGQSGHGLWIDPTSGVWRQAAGGGN 962
            :..     :||.|:...       .||.||.:||........:.....|:..|   |.......|
  Rat   939 YAG-----IRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPATQPWLADT---WPNTGNSHN 995

  Fly   963 PGGVGSCTTKEQLPGYAQATAQQGQQPTLLPDYER---------------LSPLNMPD---YAEV 1009
            ...:..|            ||..|...:.|..|.|               .:.|.:|:   |.:|
  Rat   996 DCSINCC------------TASNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDV 1048

  Fly  1010 ACS-------TFKSPT---------HGAPPMGGGGGGQSASLYDSCGAYATTNVVANVKLYQNRY 1058
            ..|       ||.||.         .|.|.                 .||||.::          
  Rat  1049 DLSNKINEMKTFNSPNLKDGRFVNPSGQPT-----------------PYATTQLI---------- 1086

  Fly  1059 ATKPNQSSGSNNNNHQGNDYQSTGMYSAPPSAHYGCLEPKQQQQQQQP---NLMTTSTASTAILT 1120
                 |::.|||.|:.|.|  |:..:..||.         ||:|:..|   |:|           
  Rat  1087 -----QANLSNNMNNGGGD--SSEKHWKPPG---------QQKQEVAPIQYNIM----------- 1124

  Fly  1121 NSPAKVKKINITENKMDQLEGKSERTN-------PFNQQQQLLLASNALKQGLGAYANTTLAAQM 1178
                       .:||::    |..|.|       |:||         :..|..|...|::.....
  Rat  1125 -----------EQNKLN----KDYRANDTIPPTIPYNQ---------SYDQNTGGSYNSSDRGSS 1165

  Fly  1179 ASGGGAGTLRRQRQPKTLYKSENNILGKSGLRQNTMNASVGAPSNGQMDF--LTGGPPSEGGDFS 1241
            .| |..|..:..|.||                         ||..|.|::  |...||:.....|
  Rat  1166 TS-GSQGHKKGARTPK-------------------------APKQGGMNWADLLPPPPAHPPPHS 1204

  Fly  1242 GLGLCNSTNQLLN-DWASSASIAAPGDYHFGSKQPSKQHLY------VKAKDG----TWSAVSSD 1295
                 ||....:: |.:....:..|       ..|::.:|.      .:|:.|    ...|.||.
  Rat  1205 -----NSEEYSMSVDESYDQEMPCP-------VPPARMYLQQDELEEEEAERGPTPPVRGAASSP 1257

  Fly  1296 AYQSFKHQ 1303
            |..|:.||
  Rat  1258 AAVSYSHQ 1265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo3NP_608592.2 Ig 23..117 CDD:472250 56/97 (58%)
Ig strand B 40..44 CDD:409353 3/3 (100%)
Ig strand C 53..57 CDD:409353 2/3 (67%)
Ig strand E 77..81 CDD:409353 2/3 (67%)
Ig strand F 95..100 CDD:409353 2/4 (50%)
Ig strand G 109..112 CDD:409353 1/2 (50%)
Ig 124..211 CDD:472250 40/87 (46%)
Ig strand B 138..142 CDD:409353 1/3 (33%)
Ig strand C 152..156 CDD:409353 1/3 (33%)
Ig strand E 176..180 CDD:409353 2/3 (67%)
Ig strand F 190..195 CDD:409353 2/4 (50%)
Ig strand G 204..207 CDD:409353 1/2 (50%)
Ig 218..302 CDD:472250 29/83 (35%)
Ig strand B 232..236 CDD:409353 1/3 (33%)
Ig strand C 245..249 CDD:409353 1/3 (33%)
Ig strand E 268..272 CDD:409353 1/3 (33%)
Ig strand F 282..287 CDD:409353 2/4 (50%)
Ig strand G 295..298 CDD:409353 1/2 (50%)
Ig 307..403 CDD:472250 34/97 (35%)
Ig strand B 323..327 CDD:409353 1/3 (33%)
Ig strand C 336..340 CDD:409353 2/3 (67%)
Ig strand E 366..372 CDD:409353 1/5 (20%)
Ig strand F 382..388 CDD:409353 2/5 (40%)
Ig strand G 396..399 CDD:409353 0/2 (0%)
Ig 413..497 CDD:472250 36/84 (43%)
Ig strand B 429..433 CDD:409353 2/3 (67%)
Ig strand C 442..446 CDD:409353 2/3 (67%)
Ig strand E 464..468 CDD:409353 2/3 (67%)
Ig strand F 479..484 CDD:409353 3/4 (75%)
Ig strand G 492..495 CDD:409353 2/2 (100%)
FN3 519..612 CDD:238020 29/92 (32%)
FN3 644..735 CDD:238020 22/93 (24%)
fn3 743..832 CDD:394996 29/90 (32%)
Robo1XP_063126810.1 None

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