DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo3 and CNTN3

DIOPT Version :10

Sequence 1:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster
Sequence 2:NP_065923.1 Gene:CNTN3 / 5067 HGNCID:2173 Length:1028 Species:Homo sapiens


Alignment Length:1177 Identity:275/1177 - (23%)
Similarity:422/1177 - (35%) Gaps:341/1177 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 PRIVEHPIDTTVP---RHEPATLNCKAEGSPTPTIQWYKDGVPLKILPGSHRITLPAGGLFFLKV 84
            |..::.|.::..|   ..:..||:|:|.|:|:|..:|..:|..:. :...||..|..|.|.   |
Human    26 PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDID-MSMEHRYKLNGGNLV---V 86

  Fly    85 VNSRRETDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNT-RIAQGDTALLECAAPRGI 148
            :|..|..|.|.|.|.|.|.||...||.|.||.|.| :.|:.:.::| .:.:|...:|.|..|...
Human    87 INPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYL-ENFKTKMRSTVSVREGQGVVLLCGPPPHS 150

  Fly   149 PEPTVTWKKGGQKLDL-EGSKRVRIVDGGNLAIQDARQTDEGQYQCI------------AKNPVG 200
            .|.:..|........: |.|:|....:.|:|.|.....:|.|.|.|:            :..|:.
Human   151 GELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLV 215

  Fly   201 VRESSLATLKVHVKPYI-IRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTAS---GGNMPLDR 261
            :|...:..   ..:|.| ::.|......:|::|...|...|:|:|.:.|.|:..   ...:.|.:
Human   216 LRSDGVMG---EYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRK 277

  Fly   262 VS-VLEDRSLRLERVTIADEGEYSCEADNVVGAITAMGTLTVYAPPKFIQRPASKSVELGADTS- 324
            .| |||..:.:.|     |.|.|.|.|:|..|...|.|.||.||.|.::|  ..|.||:..:.| 
Human   278 FSGVLEIPNFQQE-----DAGSYECIAENSRGKNVARGRLTYYAKPHWVQ--LIKDVEIAVEDSL 335

  Fly   325 -FECRAIGNPKPTIFWTIKNNSTLIFPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNA 388
             :||||.|.|||:..| :||.:.|:.          ...|:..:..||::....||..: ..|.|
Human   336 YWECRASGKPKPSYRW-LKNGAALVL----------EERTQIENGALTISNLSVTDSGM-FQCIA 388

  Fly   389 MNEVASITSRVQLSLDSQEDRPPPIIISGPVNQTLPIK--------SLATLQCKAIGLPSPTISW 445
            .|:...:.|..:|.          ::.|.|.....|:|        ||.:|.||....|....||
Human   389 ENKHGLVYSSAELK----------VVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSW 443

  Fly   446 YRDGIPVQPSSKLNITTSGDLIISDLDRQQDQGLYTCVASSRAGKSTWSGFLRIELPTNPNIKFY 510
            .:..:.||...::::...|.|.|:::.: .|.|.|||:|.::.||:..:..|.:..||       
Human   444 KKGDVSVQEHERISLLNDGGLKIANVTK-ADAGTYTCMAENQFGKANGTTHLVVTEPT------- 500

  Fly   511 RAPEQTKCPSAPGQPKILNATASALTIVWPTSDKAGASSFLGYSVEMYCTNQSRTWIPIASRLSE 575
               ..|..||        |...|                 :|.||.:.|..|....:.|      
Human   501 ---RITLAPS--------NMDVS-----------------VGESVILPCQVQHDPLLDI------ 531

  Fly   576 PIFTVESLTQGAAYMFIVRAENSLGFSPPSPISEPITAGKLVGVRDGS--ESTGTSQ-------- 630
             |||  ....||...|                           .:|||  |..|.|.        
Human   532 -IFT--WYFNGALADF---------------------------KKDGSHFEKVGGSSSGDLMIRN 566

  Fly   631 -----------LLLSDVETLLQANDVV--------ELLEANASDSTTARLSW--DIDSGQYIEGF 674
                       ::.:.|:::..|.|::        |.::.:....|||:|||  ..|:...:..:
Human   567 IQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISY 631

  Fly   675 YLYARELHSSEYKMVTLLNKGQGLSSCTVPGLAKAST-------------YEFFLVPFYKSIVGK 726
            .:.||...|..::.||           |||.:....|             |||.:|...|...|:
Human   632 SIQARTPFSVGWQTVT-----------TVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGE 685

  Fly   727 PS-NSRRMRTLEDVPEAPPYGMEAIQFNRTSVFLKWLPPQPNRTRNGILTSYNVVVKGLDV---- 786
            || .|.::||.|.|||.||..:.....:|:.:.:.| .|.|...:||....|.|..:.|.|    
Human   686 PSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVITW-DPVPEELQNGEGFGYVVAFRPLGVTTWI 749

  Fly   787 ------HNTTR-IFKNMTIDAAAPTLLLANLTTGVTYYIAVAAATRVGVGPFS----------KP 834
                  .:|.| :|:|.:|...:|            |.:.|......|.||||          :|
Human   750 QTVVTSPDTPRYVFRNESIVPYSP------------YEVKVGVYNNKGEGPFSPVTTVFSAEEEP 802

  Fly   835 AVLRIDARTQSLDTGYTRYPISRDIADDFLTQTWFIVLLGSIIAIIVFLLGALVLFKRYQFIKQT 899
            .|........||.        |.:|...:.|..|                               
Human   803 TVAPSQVSANSLS--------SSEIEVSWNTIPW------------------------------- 828

  Fly   900 SLGSLHGNHAIG-TVRKFPTLPLNGGGAVG-------AGGSNSTAAAGQSGHGLWIDPTSGVWRQ 956
               .|...|.:| .||.:     ||||...       ||...|....|...:..:.......  .
Human   829 ---KLSNGHLLGYEVRYW-----NGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAY--N 883

  Fly   957 AAGGGNPGGVGSCTTKE----QLPG--------------YAQATAQQGQ-QPTLLPDYERLSPLN 1002
            :||.|......:.|||:    |.||              :.|..|.:.: :.|....:.|.|..|
Human   884 SAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQN 948

  Fly  1003 ---------------MP---DY-AEVACSTFKSPTHGAPPMGGGGGGQSASL----YDSCGAYAT 1044
                           :|   || .||..:|           .||.|..|..:    ..|..|..:
Human   949 NVQVLNTNKTSAELVLPIKEDYIIEVKATT-----------DGGDGTSSEQIRIPRITSMDARGS 1002

  Fly  1045 TNVVANV 1051
            |:.::||
Human  1003 TSAISNV 1009

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo3NP_608592.2 Ig 23..117 CDD:472250 33/96 (34%)
Ig strand B 40..44 CDD:409353 2/3 (67%)
Ig strand C 53..57 CDD:409353 0/3 (0%)
Ig strand E 77..81 CDD:409353 2/3 (67%)
Ig strand F 95..100 CDD:409353 2/4 (50%)
Ig strand G 109..112 CDD:409353 2/2 (100%)
Ig 124..211 CDD:472250 19/100 (19%)
Ig strand B 138..142 CDD:409353 1/3 (33%)
Ig strand C 152..156 CDD:409353 0/3 (0%)
Ig strand E 176..180 CDD:409353 2/3 (67%)
Ig strand F 190..195 CDD:409353 2/16 (13%)
Ig strand G 204..207 CDD:409353 0/2 (0%)
Ig 218..302 CDD:472250 25/87 (29%)
Ig strand B 232..236 CDD:409353 1/3 (33%)
Ig strand C 245..249 CDD:409353 0/3 (0%)
Ig strand E 268..272 CDD:409353 0/3 (0%)
Ig strand F 282..287 CDD:409353 2/4 (50%)
Ig strand G 295..298 CDD:409353 1/2 (50%)
Ig 307..403 CDD:472250 27/97 (28%)
Ig strand B 323..327 CDD:409353 1/5 (20%)
Ig strand C 336..340 CDD:409353 0/3 (0%)
Ig strand E 366..372 CDD:409353 1/5 (20%)
Ig strand F 382..388 CDD:409353 1/5 (20%)
Ig strand G 396..399 CDD:409353 1/2 (50%)
Ig 413..497 CDD:472250 25/91 (27%)
Ig strand B 429..433 CDD:409353 1/3 (33%)
Ig strand C 442..446 CDD:409353 1/3 (33%)
Ig strand E 464..468 CDD:409353 2/3 (67%)
Ig strand F 479..484 CDD:409353 3/4 (75%)
Ig strand G 492..495 CDD:409353 0/2 (0%)
FN3 519..612 CDD:238020 16/92 (17%)
FN3 644..735 CDD:238020 27/114 (24%)
fn3 743..832 CDD:394996 23/99 (23%)
CNTN3NP_065923.1 Ig 25..120 CDD:472250 33/97 (34%)
Ig strand B 46..50 CDD:409353 2/3 (67%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
Ig strand E 82..86 CDD:409353 2/6 (33%)
Ig strand F 97..102 CDD:409353 2/4 (50%)
Ig strand G 111..114 CDD:409353 2/2 (100%)
Ig 129..214 CDD:472250 17/84 (20%)
Ig strand B 140..144 CDD:409353 1/3 (33%)
Ig strand C 154..158 CDD:409353 0/3 (0%)
Ig strand E 179..183 CDD:409353 2/3 (67%)
Ig strand F 193..198 CDD:409353 2/4 (50%)
Ig strand G 209..212 CDD:409353 0/2 (0%)
Ig 227..315 CDD:472250 28/92 (30%)
Ig strand B 245..249 CDD:409353 1/3 (33%)
Ig strand C 258..262 CDD:409353 0/3 (0%)
Ig strand E 280..284 CDD:409353 2/3 (67%)
Ig strand F 294..299 CDD:409353 2/4 (50%)
Ig strand G 307..310 CDD:409353 1/2 (50%)
Ig 320..403 CDD:472250 27/106 (25%)
Ig strand B 335..339 CDD:143205 0/3 (0%)
Ig strand C 348..352 CDD:143205 1/4 (25%)
Ig strand E 369..373 CDD:143205 1/3 (33%)
Ig strand F 383..388 CDD:143205 1/5 (20%)
Ig strand G 396..399 CDD:143205 1/2 (50%)
Ig 408..496 CDD:472250 25/88 (28%)
Ig strand B 427..431 CDD:409353 1/3 (33%)
Ig strand C 440..444 CDD:409353 1/3 (33%)
Ig strand E 462..466 CDD:409353 2/3 (67%)
Ig strand F 476..481 CDD:409353 3/4 (75%)
Ig strand G 489..492 CDD:409353 0/2 (0%)
Ig 498..598 CDD:472250 28/170 (16%)
Ig strand B 517..521 CDD:409439 1/3 (33%)
Ig strand C 532..536 CDD:409439 3/5 (60%)
Ig strand E 560..564 CDD:409439 0/3 (0%)
Ig strand F 574..579 CDD:409439 0/4 (0%)
FN3 579..>1006 CDD:442628 109/510 (21%)
Ig strand G 587..590 CDD:409439 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 684..713 12/28 (43%)

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