DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo3 and ihog

DIOPT Version :9

Sequence 1:	NP_608592.2	Gene:	robo3 / 33314	FlyBaseID:	FBgn0041097	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster

Alignment Length:	779	Identity:	173/779 - (22%)
Similarity:	265/779 - (34%)	Gaps:	209/779 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AQGSHPP---RIVEHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPLKILPGSHRIT-LPAG 77
            |..:||.   ||:..|.....|..:...|.|:....| ...:|            |||.: .|..
  Fly    44 AHPAHPSPGVRILRAPESLVAPLGDEVVLECETSLQP-ERFEW------------SHRSSRSPGA 95

  Fly    78 GLFFLKVVNSR----------------RETDAGIYWCEAKNELGVARSRNATLQVA--VLRDEFR 124
            |..:||...::                |....|.|.|.......|..|..|.|::|  .|.|...
  Fly    96 GFKYLKTGTAKANVSQEAAISRLRVLVRPDTLGEYRCVGWFGPLVVTSTIARLELASTSLVDAQE 160

  Fly   125 LE-PQNTRIAQGDTALLECAAPRGIPEPTVTWK--KGGQKLDLEGSKRVRIVDGGNLAIQDARQT 186
            .| |...|::.|::.|..| ..:....|:.:|.  :.|.::     |...|...|||.:.:....
  Fly   161 SESPLQWRVSAGNSVLWSC-GQQVQSNPSASWSYYRNGVEI-----KPEFIGTNGNLFLSNVSSE 219

  Fly   187 DEGQYQCIAKNPV-GVRESSLATLKVHV---------KPYIIRG-PHDQ--TVLEGASVTFPCRV 238
            ..|.|.|.|.||. |.|.....:|::.|         .|:::|| |..|  |:.||:|:...|..
  Fly   220 SSGSYSCQATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPG 284

  Fly   239 GGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRLERVTIADEGEYSCEADN-VVGAITAMGTLTV 302
            .|.|.|.|:|......|.:...|..|. ..:|.:....:.|.|.|.|..|| |..|:.....:.|
  Fly   285 VGSPPPTVVWSSPDVVGAVKNKRSKVF-GHALEISNTRVNDAGTYICFQDNGVRPALEHYIKVHV 348

  Fly   303 YAPPKFIQRPASKSVELGADTSFECRAIGNPKPTIFWTIKNNSTLIFPGAPPLDRF---HS-LNT 363
            ..||:.::.|.:.....|.....||:|.|.|.|.|:|.:..:|::....|...:.|   || |..
  Fly   349 EQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAELSNNFLILHSVLKR 413

  Fly   364 EEGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQLSLDSQEDRPPPIIISGPVNQTLPIKSL 428
            ..|:                :.|.|.|.:...::...|.::.::.:.|.  .||..::..|.:..
  Fly   414 HAGY----------------VQCFARNRLGEHSAGTLLQVNPKQIQEPR--ESGGTHRPKPNQGS 460

  Fly   429 ATLQCKAIGLPSPT--------ISWY---RDGIPVQPSSKLNITTSGDLIISDLDRQQDQGLYTC 482
            ...|......|:.|        :.|.   .||:|:              :|..:.       |..
  Fly   461 RQKQMYPPTPPNVTRLSDESVMLRWMVPRNDGLPI--------------VIFKVQ-------YRM 504

  Fly   483 VASSRAGKSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAPGQPKILNATASALTIVWPTSDKAGA 547
            |..    :..|.       .||.||.:             |:||            |
  Fly   505 VGK----RKNWQ-------TTNDNIPY-------------GKPK------------W-------- 525

  Fly   548 SSFLGYSVEMYCTNQSRTWIPIASRLSEPIFT--VESLTQGAAYMFIVRAENSLGFSPPSPISEP 610
            :|.||.|                       ||  |..|.....|.|.:.|
  Fly   526 NSELGKS-----------------------FTASVTDLKPQHTYRFRILA--------------- 552

  Fly   611 ITAGKLVGVRDGSESTGTSQLLLSDVETLLQANDVVELLEANASDSTTARLSWDI--DSGQY-IE 672
                 :....|..||..:::..|.. ...|....|.||||......|...|.|.:  |:.:: |.
  Fly   553 -----VYSNNDNKESNTSAKFYLQP-GAALDPMPVPELLEIEEYSETAVVLHWSLASDADEHLIT 611

  Fly   673 GFYLYARELHSS-EYKMVTLLNKGQGLSSCTVPGLAKASTYEFFLVPFYKSIVGKPSNSRRMRT 735
            |:|.|.|...|: ||...|:  :|....|..:..|..|:.|||.|..|..:...:.|..::.||
  Fly   612 GYYAYYRPSSSAGEYFKATI--EGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRT 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo3	NP_608592.2	Ig	22..117	CDD:299845	24/114 (21%)
		I-set	23..116	CDD:254352	23/112 (21%)
		I-set	122..211	CDD:254352	23/92 (25%)
		Ig	125..211	CDD:299845	23/89 (26%)
		I-set	215..302	CDD:254352	27/90 (30%)
		Ig	232..302	CDD:299845	18/70 (26%)
		I-set	306..401	CDD:254352	21/98 (21%)
		Ig	320..411	CDD:299845	20/94 (21%)
		I-set	412..492	CDD:254352	13/90 (14%)
		IGc2	429..489	CDD:197706	10/70 (14%)
		FN3	519..612	CDD:238020	15/94 (16%)
		FN3	644..735	CDD:238020	28/94 (30%)
		fn3	743..832	CDD:278470
ihog	NP_609085.1	IG_like	59..145	CDD:214653	19/98 (19%)
		ig	265..330	CDD:278476	19/65 (29%)
		IG_like	267..348	CDD:214653	23/81 (28%)
		Ig	314..>377	CDD:299845	17/62 (27%)
		IG_like	364..437	CDD:214653	20/88 (23%)
		IGc2	365..427	CDD:197706	19/77 (25%)
		FN3	467..565	CDD:238020	32/205 (16%)
		fn3	580..655	CDD:278470	25/76 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840