DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo3 and Unc-89

DIOPT Version :9

Sequence 1:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster
Sequence 2:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster


Alignment Length:1158 Identity:234/1158 - (20%)
Similarity:379/1158 - (32%) Gaps:363/1158 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 PRIVEHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPLKILPGSHRITLPAGGLFFLKV--- 84
            |..:..|...::..:.|.:......|.|.|||:|:||..|:..    ..|..|.....:.|.   
  Fly  2113 PTFIVQPESQSIHDYRPVSTKVLVHGVPLPTIEWFKDDKPINY----EAINKPGKDKLYAKEDTK 2173

  Fly    85 -----------VNSRRETDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTR------- 131
                       :.|.||.|.|.|.|.|.||:||.:   |..::|:|    .|.|...:       
  Fly  2174 KGTDQIESVLDIKSFRENDVGAYTCVATNEIGVTK---APFKLAML----SLAPSFVKKLDNALD 2231

  Fly   132 IAQGDTALLECAAPRGIPEPTVTWKKGGQKLDLEGSKRVRI---VDG-GNLAIQDARQTDEGQYQ 192
            :.||:..:|||... |.|.|||.|.|.|.  :::.|:.::|   .|| ..|.|...:..|.|.|:
  Fly  2232 VLQGEPLVLECCVD-GSPLPTVQWLKDGD--EVKPSESIKISTNPDGLVKLEINSCQPNDSGAYK 2293

  Fly   193 CIAKNPVG--VRESSLATLKVHVKPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTA--- 252
            .|..||.|  |...::|.....::|..::....|||:.|..:....:|.|.|.|:|.|.:..   
  Fly  2294 LIISNPHGEKVALCAVAVKPEEMQPKFLKPITSQTVVVGEPLKLEAQVTGFPAPEVKWYKDGMLL 2358

  Fly   253 ------SGGNMPLDRVSVLEDRSLRLERVTIADEGEYSCEADNVVGAITAMGTLTVY---APPKF 308
                  :..|.|..::.::.|.:..|      |.|.|.|...|..|.|..:..:.:.   :.|.|
  Fly  2359 RPSPEINFINSPNGQIGLIIDAAQPL------DAGVYKCLIANKGGEIEGVSKVEIVPKESKPVF 2417

  Fly   309 IQRPASKSVELGADTSFECRAIGNPKPTIFW-----TIK-------------NNSTLIF----PG 351
            :......|...|.....:.:.:|||||.:.|     .||             |:|:||.    ||
  Fly  2418 VAELQDASSIEGFPVKMDIKVVGNPKPKLQWFHNGHEIKPDASHIAIVENPDNSSSLIIEKTAPG 2482

  Fly   352 ------------------------APPLDR------------FHSLNTEEGHSI----------- 369
                                    ||..|.            ...:|.:||..:           
  Fly  2483 DSGLYEVIAQNPEGSTASKAKLYVAPKADETATEEAPQFVSALRDVNADEGQELVLSAPFISNPM 2547

  Fly   370 ---------LTLTRFQRTDKDLVILCNAMNEVASITSRVQLSLDS-----------QEDR----- 409
                     :|||..:|    |::.|:..:  ..:|.:...:.||           .||.     
  Fly  2548 PEVIWSKDGVTLTPNER----LLMTCDGKH--IGLTIKPAEAADSGNYTCLLANPLGEDSSACNA 2606

  Fly   410 ------PPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQPSSKLNITTSGD--- 465
                  .||:......:|.....:.|.:.....|:|.|.:.||....|:..|.|.:|...||   
  Fly  2607 NVRKVYKPPVFTQKISDQQQVFGNNAKIPVTVSGVPYPDLEWYFQDKPIPKSEKYSIKNDGDHHM 2671

  Fly   466 LIISDLDRQQDQGLYTCVASSRAGKSTWSGFL----------RIELPT----------------- 503
            ||:::.:: .|||:|.|:||:|.||....|.|          |.|.|.                 
  Fly  2672 LIVNNCEK-GDQGVYKCIASNREGKDITQGRLDIVNEIKKHSRSEPPVFLKKIGDCDIYEGMVAK 2735

  Fly   504 --------------------------------NPN------IK---------------------- 508
                                            .||      ||                      
  Fly  2736 FTACATGYPEPEVEWFKNDQKLFPSDRFLIDIEPNGLLRLTIKNVTEYDVGRYSCRIFNPYGDDI 2800

  Fly   509 -----FYRAPEQTKCP--------------SAPGQ----PKILNATASALTIVWPTSDKAGASSF 550
                 ||.:.:..:.|              .||..    |.|...|...|.:.|..|........
  Fly  2801 CHAELFYDSLDSQQKPLEDQYTDFKKYKKSGAPPPLSEGPIISRMTDRGLLLSWNPSVPLTPRYP 2865

  Fly   551 LGYSVEMYCTNQSRTWIPIASRLSEPIFTVESLTQGAAYMFIVRAENSLGFSPPSPISE------ 609
            :.|.:||....:. .|..:.:.:......:.:|.....|.|.||.||..|.|.|||.::      
  Fly  2866 ITYQIEMMDLPEG-DWRTLRTGVRSCACDIRNLEPFRDYRFRVRVENKFGVSDPSPYTQTYRQKL 2929

  Fly   610 ----PITAGKLVGVRDGSESTGTSQLLLSDVET------------LLQANDVVELLEANASDSTT 658
                |.|...|....|....|........|:|.            ||:..|:    .....|..|
  Fly  2930 VPDPPKTYTYLPPGTDFRPETSPYFPKDFDIERPPHDGLAQAPQFLLREQDI----SYGVKDHNT 2990

  Fly   659 ARLSWDIDSGQYIEGFYLYARELHSSEYKMVTLLNKGQGLSSCTVPGLAKASTYEFFL------- 716
             .|.|.:         |.|.:...:..:..:.:.:.|:...|.|..|.|     ..|:       
  Fly  2991 -ELMWFV---------YGYPKPKMTYYFDDMLIESGGRFDQSYTRNGQA-----TLFINKMLDRD 3040

  Fly   717 VPFYKSIVGKPSNSRRMRTLEDVPEAPPY---------------GMEA----IQFNRTSVFLKWL 762
            |.:|:::........|.|...::.|.|.:               .:||    |.......|..|.
  Fly  3041 VGWYEAVATNEHGEARQRVRLEIAEHPRFLKRPDETFIMARKNGRIEAKLVGIPLPEVHWFKDWK 3105

  Fly   763 P-PQPNRTRNGILTSYNVVVKGLDVHNTTRIFKNMTIDAAAPTLLLANLTTGVTYYIAVAAATRV 826
            | ...:|.:   ::||:..:..|.:|::  |.|:..:.:.:...:..:::|.||.:|.......:
  Fly  3106 PIVDSSRIK---ISSYDPDIYVLSIHDS--IIKDGGLYSISARNIAGSISTSVTVHIEENEDQYI 3165

  Fly   827 ----GVGPFSKPAVLRIDARTQSLD------TGYTRYPISRDIADDFLTQTWF 869
                |..|:.:...||...:....|      .|.|.:.:.|...|::..:..:
  Fly  3166 YKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIMY 3218

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo3NP_608592.2 Ig 22..117 CDD:299845 28/107 (26%)
I-set 23..116 CDD:254352 28/106 (26%)
I-set 122..211 CDD:254352 30/101 (30%)
Ig 125..211 CDD:299845 30/98 (31%)
I-set 215..302 CDD:254352 22/95 (23%)
Ig 232..302 CDD:299845 17/78 (22%)
I-set 306..401 CDD:254352 31/172 (18%)
Ig 320..411 CDD:299845 32/190 (17%)
I-set 412..492 CDD:254352 26/82 (32%)
IGc2 429..489 CDD:197706 22/62 (35%)
FN3 519..612 CDD:238020 26/120 (22%)
FN3 644..735 CDD:238020 16/97 (16%)
fn3 743..832 CDD:278470 20/112 (18%)
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254 28/107 (26%)
I-set 2220..2302 CDD:254352 26/84 (31%)
I-set 2318..2408 CDD:254352 22/95 (23%)
I-set 2415..2506 CDD:254352 18/90 (20%)
I-set 2519..2608 CDD:254352 14/94 (15%)
I-set 2615..2696 CDD:254352 25/81 (31%)
I-set 2717..2805 CDD:254352 5/87 (6%)
FN3 2834..2925 CDD:238020 22/91 (24%)
I-set <2996..3063 CDD:333254 12/80 (15%)
I-set 3067..3157 CDD:333254 17/94 (18%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 5/37 (14%)
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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