DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo3 and Robo3

DIOPT Version :9

Sequence 1:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster
Sequence 2:XP_038937330.1 Gene:Robo3 / 315564 RGDID:1311018 Length:1451 Species:Rattus norvegicus


Alignment Length:1471 Identity:408/1471 - (27%)
Similarity:612/1471 - (41%) Gaps:289/1471 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 PRIVEHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPLKIL---PGSHRITLPAGGLFFLKV 84
            |||||.|.|..|.|.|||||.|:|||.|.|.|:|||:|..:...   |.:||:.||:|.|||.::
  Rat    77 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPSGALFFPRI 141

  Fly    85 VNSRR-ETDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECAAPRGI 148
            |:.|| ..|.|:|.|.|:|.||.|.||||:|:||||||:||..|.|..:|.|:.|::||..|:|.
  Rat   142 VHGRRSRPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVMECVPPKGH 206

  Fly   149 PEPTVTWKKGGQKL-DLEGSKRVRIVDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLATLKVH 212
            |||.||||||..|| :.||...:|   ||.|.:....::|.|.|.|:|.|..|.|||..|.|.|.
  Rat   207 PEPLVTWKKGNTKLKEEEGRITIR---GGKLMMSHTFKSDAGMYMCVASNMAGERESGAAELVVL 268

  Fly   213 VKPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRLERVTI 277
            .:|..:|.|.:|.||..|.|.|.|.|.|||.|::.|.:  ..|.:|..|..:..|.||.:|:|:.
  Rat   269 ERPSFLRRPINQVVLADAPVNFLCEVQGDPQPNLRWRK--DDGELPTGRYEIRSDHSLWIEQVSA 331

  Fly   278 ADEGEYSCEADNVVGAITAMGTLTVYAPPKFIQRPASKSVELGADTSFECRAIGNPKPTIFWTIK 342
            .|||.|:|.|:|.||...|.|:|:|:.||:|:.:|.:::...|.:.||:|...|||.|.|||..:
  Rat   332 EDEGTYTCVAENSVGRAEASGSLSVHVPPQFVTKPQNQTAAPGENVSFQCETKGNPPPAIFWQKE 396

  Fly   343 NNSTLIFP--GAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQLSLDS 405
            .:..|:||  ...|:.|.  |.:..|.  |.:|..:..|....: |.|::...||.::..|.:..
  Rat   397 GSQVLLFPSQSLQPMGRL--LVSPRGQ--LNITEVKIGDGGYYV-CQAVSVAGSILAKALLEIKG 456

  Fly   406 QE-DRPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQ-PSSKLNITTSGDLII 468
            .. |..||||:.||.||||.:.|...|.|:.||.|.|.:.|.:|...:| .:|:.|:..:|.|.|
  Rat   457 ASIDGLPPIILQGPANQTLVLGSSVWLPCRVIGNPQPNVQWKKDETWLQGDNSQFNLMDNGTLYI 521

  Fly   469 SDLDRQQDQGLYTCVASSRAGKSTWSGFLR-----------IELPTNPNIKFYRAPEQTKCPSAP 522
            :.: ::.|.|.|:|||.|..|::||:.:||           ...|.||             |..|
  Rat   522 ASV-QEMDMGFYSCVAKSSIGEATWNSWLRKREHWGASPGPATEPGNP-------------PGPP 572

  Fly   523 GQPKILNATASALTIVWPTSDKAGASSFLGYSVEMYCTNQSRTWIPIASRLSEPIFTVESLTQGA 587
            .||.:...|.:::|:.|..:.::||.: ..|.:|.:......||..:|..:.....||..|....
  Rat   573 SQPIVTEVTTNSITLTWKPNPQSGARA-TSYVIEAFSQAAGNTWRTVADGVQLETHTVSGLQPNT 636

  Fly   588 AYMFIVRAENSLGFSPPSPISEPITAGKLVGVRDGS-----ESTGTSQLLLSDVETLLQANDVVE 647
            .|:|:|||..:.|.|.|||:|||      |..:|.|     |.....|..|::|        .|.
  Rat   637 IYLFLVRAVGAWGLSEPSPVSEP------VQTQDSSLSRPVEDPWKGQQGLAEV--------AVR 687

  Fly   648 LLEANASDSTTARLSWDIDS-GQYIEGFYLYARELHSSEYKMVTLLNKGQGLSSCTVPGLAKAST 711
            :.|.......|.::||.::. ||.::||.:..|.....:.....|..:.....|..:.||...|.
  Rat   688 MQEPIVLGPRTLQVSWTVEGPGQLVQGFRVSWRIAGLDQGSWTALDVQSPHKQSTVLRGLPPGSQ 752

  Fly   712 YEFFLVPFYKSIVGKPSNSRRMRTLEDVPEAPPYGME-AIQFNR-TSVFLKWLPPQPNRTRNGIL 774
            .:..:....:..:|..|.|......|:.|..||.|:. |:..:| :|:.:.|.||.|:: :||::
  Rat   753 IQIKVQVQGQEGLGAESPSVTRSIPEEAPSGPPQGVAVALGGDRNSSITVSWEPPLPSQ-QNGVI 816

  Fly   775 TSYNVVVKGLDVHNTTRIFKNMTIDAAAPTLLLANLTTGVTYYIAVAAATRVGVGPFSKPAVLRI 839
            |.|.:...|    |.:|...|.:....|.:::...|..|:.|...|||||..|||..|.|.::::
  Rat   817 TEYQIWCLG----NESRFHLNRSAAGWARSVMFRGLLPGLLYRAIVAAATSAGVGVASAPVLVQL 877

  Fly   840 DARTQSLDTGYTRYP--------ISRDIADDF---LTQTWFIVLLGSIIAIIVFLLG-ALVLFKR 892
            .            :|        :|..:|:..   |.:..|  |.||..|....||| ...|::|
  Rat   878 P------------FPPVAEPGPEVSEGLAERLSRVLRKPAF--LAGSSAACGALLLGLCAALYRR 928

  Fly   893 YQFIKQTSLGSLHGN------------HAIGTVRKFPTL-----PLNGG----GAVGAGGSNSTA 936
            .:..|:.|    |..            ::.|.....|.|     ||:..    .:.|..||:|..
  Rat   929 QKQRKELS----HYTASFAYTPAGKRLYSSGLRTPIPALLLPLSPLSSSVSFPHSEGLSGSSSRP 989

  Fly   937 AAGQSGHGLWIDPTSGVW--------RQAAGGGNPGGVGSCTTKEQLPG-----------YAQAT 982
            ..|       :.|.:..|        .::.....|.  |||......|.           |...|
  Rat   990 PMG-------LGPAAYPWLADSWPHPSRSPSAQEPR--GSCCPSNPDPDDRYYNEAGISLYLAQT 1045

  Fly   983 AQQGQQPTLLPDYERLSPLNMPDYAEVACSTFKSPTHGAPPMGGGGGGQSASLYDSCGAYATTNV 1047
            |:....|...|.|..:.|:.      ....||    ||..|....|...:.|.|           
  Rat  1046 ARGANAPGEGPVYSTIDPVG------EELQTF----HGGFPQHSSGDPSTWSQY----------- 1089

  Fly  1048 VANVKLYQNRYATKPNQSSGSNNNNHQGNDYQSTG-------------MYSAPPSAHYGCLEPKQ 1099
                        ..|..|.|  ::..:|...:..|             :...|||....|.|..:
  Rat  1090 ------------APPEWSEG--DSGARGGKGKLLGKPVQMPSLSWPEALPPPPPSCELSCPEGPE 1140

  Fly  1100 QQQQQQPNL------------MTTSTASTAIL-----------TNSPAKVKKINITENKMDQLEG 1141
            ::.:...:|            :..|.:|.|.:           |:|..:.....:|.:..|..:.
  Rat  1141 EELKGSSDLEEWCPPMPEKKHLIDSRSSGACMVAPARGETPSPTSSYGQQSTATLTPSPPDPPQP 1205

  Fly  1142 KSE--------------RTNPFNQQQQLLLASNALKQGLGA-----YANTTLAAQMASGGGAGTL 1187
            .|:              .::|.:..|..|.:.:....||||     |..:.......:....|  
  Rat  1206 PSDIPHLHQMPRRVPLGPSSPLSVSQPALSSHDGRPVGLGAGPIVSYHPSPSPVPSTASSAPG-- 1268

  Fly  1188 RRQRQPKTLYKSENNILGK-----SGLRQNTMNASVGAP-----SNGQMDFLTGGPPSEGGDFS- 1241
             |.||          :.|:     .|.|......:...|     |.|.:......||.|...:. 
  Rat  1269 -RTRQ----------VTGEMTPPLHGHRARIRKKTKALPHRREHSPGDLPPPPLPPPEEETSWPL 1322

  Fly  1242 GLGLCNSTNQLLNDWASSASI--AAPGDYHFGSKQPSKQH-------LYVKAKDGTWSAVSSDAY 1297
            ||....|.:.|..:.:....:  |.|    .|::.|..|.       |...|.:..|......::
  Rat  1323 GLRAAGSMSSLEREHSGERRVAQAVP----LGAQPPGAQRGPHPDAALLGCAAEEAWLPYGRPSF 1383

  Fly  1298 QSFKHQQQHHPFLAGSGDNTKSLASVNSLAGDSKFLSSFGS 1338
            .|.           |.|.:|.|.|..||..|.:....|.||
  Rat  1384 LSH-----------GQGTSTCSTAGSNSSRGSNSSRGSRGS 1413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo3NP_608592.2 Ig 22..117 CDD:299845 51/97 (53%)
I-set 23..116 CDD:254352 51/96 (53%)
I-set 122..211 CDD:254352 40/89 (45%)
Ig 125..211 CDD:299845 38/86 (44%)
I-set 215..302 CDD:254352 36/86 (42%)
Ig 232..302 CDD:299845 29/69 (42%)
I-set 306..401 CDD:254352 28/96 (29%)
Ig 320..411 CDD:299845 27/93 (29%)
I-set 412..492 CDD:254352 32/80 (40%)
IGc2 429..489 CDD:197706 21/60 (35%)
FN3 519..612 CDD:238020 30/92 (33%)
FN3 644..735 CDD:238020 18/91 (20%)
fn3 743..832 CDD:278470 30/90 (33%)
Robo3XP_038937330.1 Ig strand A 182..185 CDD:409353 1/2 (50%)
Ig strand A' 187..191 CDD:409353 1/3 (33%)
Ig strand B 195..202 CDD:409353 3/6 (50%)
Ig strand C 210..215 CDD:409353 3/4 (75%)
Ig strand C' 217..220 CDD:409353 0/2 (0%)
Ig strand D 226..230 CDD:409353 0/3 (0%)
Ig strand E 232..238 CDD:409353 2/5 (40%)
Ig strand F 245..253 CDD:409353 4/7 (57%)
Ig strand G 256..267 CDD:409353 6/10 (60%)
Ig 274..356 CDD:416386 35/83 (42%)
Ig strand A 274..277 CDD:409353 1/2 (50%)
Ig strand A' 279..283 CDD:409353 1/3 (33%)
Ig strand B 286..295 CDD:409353 4/8 (50%)
Ig strand C 301..306 CDD:409353 1/4 (25%)
Ig strand C' 309..312 CDD:409353 1/2 (50%)
Ig strand D 315..320 CDD:409353 1/4 (25%)
Ig strand E 321..328 CDD:409353 3/6 (50%)
Ig strand F 335..343 CDD:409353 4/7 (57%)
Ig strand G 346..356 CDD:409353 4/9 (44%)
Ig 361..458 CDD:416386 28/101 (28%)
Ig strand A 361..365 CDD:409353 1/3 (33%)
Ig strand A' 367..371 CDD:409353 0/3 (0%)
Ig strand B 377..385 CDD:409353 3/7 (43%)
Ig strand C 388..395 CDD:409353 4/6 (67%)
Ig strand C' 397..400 CDD:409353 0/2 (0%)
Ig strand D 413..418 CDD:409353 2/6 (33%)
Ig strand E 420..427 CDD:409353 3/8 (38%)
Ig strand F 433..442 CDD:409353 2/9 (22%)
Ig strand G 444..455 CDD:409353 3/10 (30%)
Ig 465..549 CDD:416386 33/84 (39%)
Ig strand A 465..468 CDD:409353 2/2 (100%)
Ig strand A' 472..475 CDD:409353 2/2 (100%)
Ig strand B 481..488 CDD:409353 2/6 (33%)
Ig strand C 494..499 CDD:409353 1/4 (25%)
Ig strand C' 501..503 CDD:409353 0/1 (0%)
Ig strand D 510..514 CDD:409353 1/3 (33%)
Ig strand E 517..522 CDD:409353 2/4 (50%)
Ig strand F 530..538 CDD:409353 5/7 (71%)
Ig strand G 541..549 CDD:409353 3/7 (43%)
FN3 569..662 CDD:238020 31/99 (31%)
FN3 693..773 CDD:238020 16/79 (20%)
FN3 783..876 CDD:238020 32/97 (33%)
Ig 77..175 CDD:416386 51/97 (53%)
Ig strand A 77..81 CDD:409353 3/3 (100%)
Ig strand A' 84..89 CDD:409353 1/4 (25%)
Ig strand B 93..101 CDD:409353 5/7 (71%)
Ig strand C 107..112 CDD:409353 2/4 (50%)
Ig strand C' 115..117 CDD:409353 0/1 (0%)
Ig strand D 128..131 CDD:409353 1/2 (50%)
Ig strand E 134..140 CDD:409353 4/5 (80%)
Ig strand F 152..160 CDD:409353 4/7 (57%)
Ig strand G 163..175 CDD:409353 7/11 (64%)
Ig 182..267 CDD:416386 39/87 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 106 1.000 Domainoid score I6432
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D173520at2759
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 1 1.000 - - mtm9043
orthoMCL 1 0.900 - - OOG6_101537
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X493
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.820

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